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Tumor tissue three-dimensional space sampler and sampling method thereof

A three-dimensional space, tumor tissue technology, applied in the field of tumor sampling, can solve the problems of adverse effects of freshness, waste of time, etc.

Pending Publication Date: 2017-04-05
志诺维思(北京)基因科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Among them, since tumor tissue is a precious sample with relatively high requirements on time and storage conditions, the method of point-by-point sampling wastes more time, which adversely affects the freshness of tumor tissue sampling

Method used

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  • Tumor tissue three-dimensional space sampler and sampling method thereof
  • Tumor tissue three-dimensional space sampler and sampling method thereof
  • Tumor tissue three-dimensional space sampler and sampling method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0049] Such as figure 1 , figure 2 , image 3 , Figure 4 , Figure 5 and Figure 6 As shown, an embodiment of the present invention proposes a tumor tissue three-dimensional space sampler, which includes:

[0050]The sampling assembly includes: a sampling platform 10, the first end of the sampling platform 10 has a pressing part 11, the second end of the sampling platform 10 has a plurality of sampling needles 12, and the rear end of the sampling needles 12 is connected to the pressing part 11 , the front end of the sampling needle tube 12 is used as a needle socket, and the two ends of the sampling channel in the sampling needle tube 12 communicate with each other; wherein, in the length direction of the sampling needle tube, there is at least one sectional ring mark 121 on the outer wall of the sampling needle tube , such as more than 2, more than 3, more than 4, etc.;

[0051] The sample-dividing component includes a section folder 21 for cutting the sectional ring ...

example

[0084] Standard general-length tumor tissue three-dimensional space sampler: the sampling platform has 24 sampling needles, the sampling needles are stainless steel tubes with a diameter of 1.5 mm, the length of the sampling needles is 25 mm, the front end is ground with a cutting edge, and there are 7 section ring marks. The sampling needle tube can be divided into 7 sections (each section is about 3 mm long, and each section can be divided into 3 sample data points), and each section is engraved with upper and lower orientation marks. 3mm thick silicone plate, 5mm thick KT plate.

[0085] Standard extended tumor tissue three-dimensional space sampler: the sampling platform has 24 sampling needle tubes, the sampling needle tube is a stainless steel tube with a diameter of 1.5mm, the length of the sampling needle tube is 38mm, the front end is ground with a cutting edge, and there are 12 section ring marks. The sampling needle tube can be divided into 12 sections (each section...

Embodiment 2

[0089] A sampling method provided in Embodiment 2 of the present invention uses the tumor tissue three-dimensional space sampler described in Embodiment 1 above, and the method includes:

[0090] Sampling step: align multiple sampling needles at the second end of the sampling platform with the tissue samples, apply external force to the pressing part, insert the sampling needles into the tissue samples, and pour part of the tissue samples into the sampling channels of the sampling needles ; Then apply an external force to the pressing part, pull out the sampling needle tube from the tissue sample, so that part of the tissue sample poured into the sampling channel of the sampling needle tube is pulled out along with the sampling needle tube;

[0091] Among them, the tissue sample itself needs to distinguish the orientation of up, down, left, and right. When placing the tissue sample, it needs to be placed in alignment according to the orientation to be detected; apply external f...

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Abstract

The invention relates to a tumor tissue three-dimensional space sampler and a sampling method thereof, and relates to the technical field of tumor sampling. The main purpose of the invention is to improve the space sampling efficiency. The sampling method comprises the following steps: 1, sampling: aligning a plurality of sampling syringes loaded on a sampling platform at a tissue sample, and inserting the sampling syringes into the tumor tissue sample to make the sampling channels of the sampling syringes filled with a part of the tissue sample; and 2, dividing the sample: using a breaker to align at the interception ring marks of the sampling syringes, cutting the sampling syringes to segment the sampling syringes, carrying out segmented sampling on the different sampling syringes, and carrying out numbering sample dividing according to the spatial positions of the segmented sampling syringes in the sampling syringes to conveniently correspond to the spatial positions in tumors. Compared with existing manual single-point sampling technologies, the method disclosed in the invention has the advantages of short time, realization of obtaining of a plurality of samples from the three-dimensional space of the tumors at one time, and facilitation of the study of tumor space heterogeneity.

Description

technical field [0001] The invention relates to the technical field of tumor sampling, in particular to a tumor tissue three-dimensional space sampler and a sampling method thereof. Background technique [0002] Tumor is an abnormal lesion formed by the body under the action of various carcinogenic factors when a certain cell in a local tissue loses its normal regulation of its growth at the gene level, resulting in its clonal abnormal proliferation. [0003] Tumor heterogeneity is one of the characteristics of malignant tumors, which means that during the growth process of the tumor, after multiple divisions and proliferation, its daughter cells show changes in molecular biology or genes, so that the growth rate and invasion ability of the tumor , sensitivity to drugs, prognosis and other aspects of the difference. [0004] In practice, there are many types of tumors on different individuals (humans or animals), and the tumors removed from the same individual are also diff...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N1/16
CPCG01N1/16
Inventor 凌少平郝伶童
Owner 志诺维思(北京)基因科技有限公司
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