18 results about "Heterotaxy" patented technology

The invention relates to a device for distributing and receiving a population of pancreatic islets heterogeneous in size, the device comprising a matrix having a first face opposite a second face, characterized in that the matrix comprises concentric channels centered on a center O, the channels have an opening for receiving the pancreatic cells, the opening leading out onto the first face, the opening extending over the entire length (L) of the channel, the opening having a width (I) taken along the section Si, the device being configured such that the widths of the opening of two adjacent channels have an equal or increasing value moving away from the center O and such that the widths of the opening of a channel closest to the center O and of a channel furthest from the center O have an increasing value moving away from the center O. The invention relates to the field of implantable devices, in particular artificial pancreas devices.

The invention relates to the technical field of image processing, and further relates to a tumor characteristic spectrum construction method based on CTC enrichment and multi-omics analysis. The method comprises the following steps: 1, sequentially carrying out spiral inertial focusing and deterministic lateral displacement sorting on a whole blood sample to be detected, and finishing single-cell microcavity positioning capture of circulating tumor cells in a single-cell microcavity capture array region; 2, acquiring a time-varying curve of an oxygen molecule concentration value for each positioned and captured circulating tumor cell, and acquiring a metabolic function characteristic parameter group; 3, forming a multi-omics joint feature vector in combination with the metabolic function feature parameter group; and 4, constructing a circulating tumor cell subset based on the multi-omics combined feature vector, extracting symbolic molecular features, and integrating and outputting a tumor feature spectrum. According to the invention, more stable technical support can be provided for tumor heterogeneity analysis, metastasis potential evaluation and curative effect monitoring.

The invention belongs to the technical field of biomedical materials and tissue engineering, and particularly relates to a self-pumping stent material with a double-layer heterogeneous structure as well as a preparation method and application of the self-pumping stent material. A hydrophobic membrane is prepared by an electrostatic spinning technology, and a hydrophilic microgel assembly is prepared by an emulsion method. Adding a dopamine modified polymer, and establishing a dynamic phenylboronic acid ester bond between microgel through a dopamine group to form a hydrophilic microgel assembly; the adhesion connection of the microgel assembly and the hydrophobic membrane is realized through mussel bionic chemical reaction of dopamine groups, and a double-layer heterogeneous structure based on the hydrophilic assembly and the hydrophobic membrane is constructed, so that a self-pumping effect is generated, and one-way flow of liquid components from the hydrophobic side of the stent to the hydrophilic side of the stent can be realized. Implanting the stent into an alveolar bone defect wherein the hydrophobic membrane contacts gingiva and the hydrophilic microgel assembly fills the bone defect; through the self-pumping effect of the stent, nutritional ingredients in the gingiva are unidirectionally pumped to the defect part of the alveolar bone, so that the regeneration of the alveolar bone is promoted.

According to an aspect of the present invention, there is provided a method for imaging vasa vasorum density of a vessel in the body such as coronary and carotid arteries and the aorta and thereby assessing the risk of adverse health outcomes for a patient, comprising administering a contrast agent to the patient; performing a contrast-enhanced CT scan to measure Hounsfield distribution and heterogeneity related to vasa vasorum density in and around the vessel wall of a patient; analyzing the data to determine a metric related to the density of the vasa vasorum; and recommending a diagnostic and / or therapeutic next step to the patient to prevent adverse health outcomes based at least in part on the metric related to the vasa vasorum density.

The invention discloses a multi-omics malignant pleural effusion immunometabolism reprogramming spatio-temporal heterogeneity analysis device, which comprises an integration analysis module used for carrying out multi-modal integration and consensus clustering analysis on a multi-omics data set to obtain an integration analysis result, dividing the malignant pleural effusion training samples of the malignant pleural effusion patient into an immunometabolism activation type subtype, an immunometabolism transition type subtype and an immunometabolism inhibition type subtype according to the confluence analysis result; the screening construction module is used for screening immune metabolism markers from the characteristics of the immune metabolism inhibition type subtypes, forming a candidate target point set according to the immune metabolism markers, and constructing a prediction model; and the evaluation suggestion module is used for calculating treatment response scores and combining the treatment response scores with the clinical staging information to construct a column diagram, and a prognosis risk evaluation result and personalized treatment guidance suggestions are obtained, so that the accuracy of prognosis evaluation and the reliability of treatment response prediction can be improved, and accurate risk stratification and personalized treatment guidance for patients can be realized.

The invention discloses a liver cancer iconography diagnosis method based on artificial intelligence, which integrates anatomical structure characteristics of CT enhanced scanning, soft tissue heterogeneity characteristics of MRI diffusion weighted imaging and dynamic blood flow characteristics of ultrasound contrast, and covers three dimensions of morphology, histology and hemodynamics of a focus. The one-sidedness defect of single-mode information is overcome, multi-mode data complementation is achieved, the misdiagnosis and missed diagnosis risks caused by feature missing are effectively reduced, and the diagnosis accuracy is improved. The cross-modal attention module calculates the cosine similarity between each modal and the global reference feature and dynamically distributes the weight, thereby avoiding the limitation of the fixed weight, enabling different modal features to make accurate contributions according to the actual expression of the focus, strengthening the characterization capability of the combined feature for the liver cancer focus, and improving the accuracy of the liver cancer focus. And the recognition precision of the model on difficult focuses such as fuzzy boundaries and complex blood supply is improved.

A computer-implemented method for determining a risk of having or developing steatohepatitis and / or a complication thereof in a subject. The method includes the steps of: receiving at least one image of the subject and at least one clinical and / or biological data, both previously obtained from the subject; calculating a score of fat infiltration heterogeneity on the at least one image based on at least one radiomic feature obtained for a region of interest including at least one skeletal muscle; combining the calculated score of fat infiltration heterogeneity with the at least one clinical and / or biological data previously obtained from the subject; determining a risk for the subject of having or developing steatohepatitis and / or a complication thereof based on the combination of the calculated score of fat infiltration heterogeneity with the at least one clinical and / or biological data.

The invention discloses an osteoporotic bone sample sampling device, and belongs to the technical field of sample sampling, the osteoporotic bone sample sampling device comprises a sampling platform, one side of the sampling platform is provided with a control panel, and the center of the surface of the top end of the sampling platform is welded with a material guide disc; meanwhile, the surface of the top end of the material guiding disc is communicated with a collecting box at the bottom of the sampling platform, adjustable fixed rotating assemblies are welded to the two sides of the material guiding disc and used for clamping and fixing bone tissue samples of different positions and different densities, and multi-direction rotating assemblies are welded to the tops of the adjustable fixed rotating assemblies and used for drilling the bone samples from multiple angles. By adopting the adjustable fixed rotating assembly and the multi-direction rotating assembly, the equipment can perform multi-angle and multi-direction sampling at the same position and in the same direction, the heterogeneity of bone tissues can be captured more comprehensively, and errors or local deviation possibly generated by single-direction sampling are avoided.

The invention discloses a tumor metastasis risk assessment method and system based on circulating tumor DNA (ctDNA) spatial heterogeneity. The core of the method is as follows: blood samples of at least two different anatomical sites (such as peripheral veins and tumor drainage veins) of the same subject are obtained at the same time, and ctDNA in the samples is subjected to sequencing analysis; calculating characteristic data (such as a relative abundance ratio) representing ctDNA spatial distribution based on the mutation abundance difference between different parts; and finally, inputting the feature data into a pre-trained metastasis risk assessment model, and outputting a quantitative tumor metastasis risk score. According to the method, the limitation of traditional single-point liquid biopsy is broken through, the detection sensitivity of tiny metastases can be remarkably improved by utilizing the spatial distribution information of the ctDNA, potential metastasis positioning information is provided, and powerful technical support is provided for accurate diagnosis and treatment decision of tumor patients.

The present application relates to the technical field of intraoperative navigation, and particularly relates to an intraoperative brain glioma deep learning detection method and system based on hyperspectral imaging, the steps of the method comprising: analyzing the internal heterogeneity of brain glioma based on spectral difference, evaluating the coverage benefits of preoperative planning path and intraoperative detour path; analyzing the blood oxygen saturation distribution based on the absorption peak characteristics of hemoglobin in a specific wave band, evaluating the risk of local ischemia of the preoperative planning path and the intraoperative detour path; mapping the preoperative planning path and the intraoperative detour path to the brain function area topology network respectively, and evaluating the functional damage risk of the paths based on the topological connection relationship and the risk of local ischemia; analyzing the expected benefits and risk trends of the preoperative planning path and the intraoperative detour path, and generating surgical path decision suggestions. The present application quantifies the path coverage benefits and functional damage risks of the surgical path, effectively improving the accuracy and safety of the surgical path decision.

Ultrasound images of a patient's cornea or sclera include speckles that can be tracked between frames to measure tissue displacement, such as during a heartbeat that changes intraocular pressure. Speckle tracking techniques and noise reduction filters allow for the strain within the tissue to be calculated and compared to known thresholds to determine stiffness. These measures will be used to diagnose keratoconus and other ophthalmology disorders at an early stage, as an abnormally low stiffness or heterogeneity in stiffness will indicate high risk for progression of certain diseases.

A beam angle optimization method for particle therapy comprises: receiving, by an analysis apparatus, distance information from a patient's body surface to a tumor, internal heterogeneity information, internal transmission information of a particle beam, and internal motion information according to the patient's respiration; inputting, by the analysis apparatus, the distance information from the patient's body surface to the tumor, the internal heterogeneity information, the internal transmission information of the particle beam, and the internal motion information according to the patient's respiration into a deep learning model; and calculating, by the analysis apparatus, a particle therapy beam angle based on an output value of the deep learning model.

This invention relates to a method and medium for quantifying biomechanical heterogeneity and predicting prognosis in hepatocellular carcinoma (HCC) based on a multi-scale mechanical interaction network. The method includes: retrieving the shear modulus and loss angle parameter maps of the tumor based on multi-frequency magnetic resonance elastography data; dividing the tumor into multiple biomechanical regions using mechanical gradient-driven adaptive clustering; constructing an intratumoral mechanical interaction network and extracting its topological features; constructing a multi-organ mechanical coupling model of the tumor, liver, and spleen, and calculating the cross-organ stress transfer efficiency as a coupling feature; fusing intratumoral network features and cross-organ coupling features to form a multi-scale biomechanical phenotypic vector, and inputting it into a machine learning model in conjunction with clinical features to achieve individualized and accurate prediction of postoperative recurrence risk in HCC patients. Compared with existing technologies, this invention provides a novel systemic biomechanical perspective for prognostic assessment by quantifying the intratumoral mechanical heterogeneity and its mechanical interaction with host organs.

Methods for using tumor heterogeneity score as a biomarker to guide treatment and / or patient monitoring decisions are described. The methods may comprise, for example, acquiring knowledge of a driver mutation in a sample obtained from a subject; identifying one or more variants present in the sample; determining a tumor heterogeneity score for the sample based on the one or more variants; and comparing the tumor heterogeneity score for the sample to a threshold tumor heterogeneity score, where if the tumor heterogeneity score is less than or equal to the threshold tumor heterogeneity score, the subject is identified for treatment with a first anti¬ cancer agent, and where if the tumor heterogeneity score is greater than the threshold tumor heterogeneity score, the subject is identified for treatment with a second anti-cancer agent.

The application relates to the technical field of medical image processing and intelligent tumor grading recognition, and discloses a head and neck squamous carcinoma early recognition method based on imaging and deep learning, which comprises the following steps: acquiring head and neck CT, MRI and PET three-mode image data; adopting a two-stage dynamic structure alignment mechanism for registration; extracting fused imaging features; constructing a tumor sub-feature map; outputting a tumor grade and a prediction confidence through an uncertainty prediction model; and generating a saliency explanation heat map. Compared with the prior art which depends on single-mode images or shallow texture feature extraction models, especially under the condition that the boundary of a heterogeneous tumor region is fuzzy, different modes exist significant structure offset, the technical problem that high confidence precision discrimination of a real tumor staging state cannot be realized. Since the saliency guided registration mechanism and the improved graph convolutional neural network are introduced and combined with Dropout reasoning, the accuracy of the head and neck squamous carcinoma early stage recognition is improved.

The invention relates to a construction method and application of a congenital heart disease animal model, and belongs to the technical field of biology. According to the method, a Wt1 CreERT2 mouse with inducible tissue specific expression is mated with an Actg1 flox mouse, after a filial generation mouse is obtained, tamoxifen is used for induced knockout in a specific period of embryonic development, and specific knockout of the Actg1 gene in the epicardium is achieved. The method can stably and repeatedly construct the ventricular septal defect model with highly consistent phenotype, overcomes the problems of high phenotype heterogeneity and low intervention precision in the prior art, and is suitable for mechanism research and drug screening of congenital heart diseases.

Methods and systems for determining a tumor heterogeneity score based on genomic data for a patient that is predictive of the estimated duration of the patient's response to a selected treatment for a given disease, e.g., a cancer, are described. In some instances, for example, the methods may comprise: receiving genomic data for a subject having a disease, wherein the genomic data indicates the presence of one or more short variants in a sample derived from the subject; determining a plurality of cancer cell fraction (CCF) measures by calculating a CCF measure for each of the one or more short variants; determining a tumor heterogeneity score (THS) based on the plurality of CCF measures; comparing the tumor heterogeneity score to one or more predetermined THS thresholds; and predicting an estimated duration of the subject's response to a therapy for treating the disease based on the comparison.

The invention belongs to the technical field of medical diagnosis, and particularly relates to a method and system for fusing nanoindentation sensing and real-time visual feedback. According to the method, mechanical characteristic parameters of lung tissue are obtained in real time through a nanoindentation sensing technology, mechanical heterogeneity between tumor tissue and normal tissue is effectively captured, space registration is carried out on the mechanical characteristic parameters and surgical navigation images, a fusion visual image is generated, and the mechanical heterogeneity between the tumor tissue and the normal tissue is obtained. The limitation that a traditional preoperative image cannot reflect tissue changes in the operation in real time is overcome, a sliding window mechanism is combined with secondary indentation verification, stable mechanical characteristic parameters are effectively screened out, through multi-dimensional mechanical characteristic comparison and geometric characteristic analysis, a lesion area can be accurately recognized and mapped to a navigation image, and the accuracy and accuracy of the image are improved. The problems that images are not matched with anatomy and small focuses are difficult to recognize are solved, an operator can accurately plan the excision range, and the risk of excessive excision or lesion residues is reduced.