Quantitative description method of PET image nasopharyngeal carcinoma intra-tumor heterogeneity

Abstract

The invention belongs to the field of the medical image analysis, specifically a quantitative description method of PET image nasopharyngeal carcinoma intra-tumor heterogeneity. The method comprises the following steps: acquiring PET / CT scanning data of a patient, and converting the PET / CT scanning data into a standard SUV image; performing three-dimensional segmentation on the primary focus at the nasopharynx; performing discretization processing on the focus, and constructing four image omics matrixes for the processed focus, and comprehensively considering five parameter settings of symmetry, the average policy, the distance, the neighborhood number and window width size in the matrix construction process; extracting 415 texture features from the constructed matrix, and realizing the quantitative description of the intra-tumor metabolic heterogeneity by combining five traditional SUV features. The intra-tumor metabolic heterogeneity is described more comprehensively by sufficientlymining the information contained in the non-invasive PET image, thereby providing the quantitative evaluation index for precisely identifying the nasopharyngeal carcinoma by the doctor.

Description

technical field [0001] The invention relates to the technical field of medical image analysis, in particular to a method for quantitatively describing intratumoral heterogeneity of nasopharyngeal carcinoma in PET images. Background technique [0002] Nasopharyngeal carcinoma is an endemic disease that occurs mostly in southern China, with up to 30 cases per 100,000 people. 18 F-FDG PET / CT has been widely used in the examination of nasopharyngeal carcinoma. However, because benign inflammatory lesions usually also show high glucose uptake, radiologists cannot observe the metabolic intensity and anatomical shape of the lesion with naked eyes. Realize the quantitative description of intratumoral heterogeneity image area. Therefore, the identification of early nasopharyngeal carcinoma is easily interfered by inflammatory lesions, resulting in less than 85% specificity, and its diagnosis still depends on traumatic histopathological biopsy. Texture features have demonstrated the...

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Problems solved by technology

18 F-FDG PET / CT has been widely used in the examination of nasopharyngeal carcinoma. However, because benign inflammatory lesions usually also show high glucose uptake, radiologists cannot observe the metabolic intensity and anatomical shape of lesions with naked eyes. Quantitative characterization of intratumoral heterogeneity image regions

Therefore, the identification of early nasopharyngeal carcinoma is easily interfered by inflammatory lesions, resulting in a specificity of less than 85%, and its diagnosis still relies on traumatic histopathological biopsy

However, the prior art methods for constructing texture matrices are relatively simple, and do not fully consider the influence of parameter settings such as symmetry, averaging strategy, distance, number of neighbors, and window width in the process of matrix construction, which greatly limits the texture matrix. Sufficiency and comprehensiveness of quantitative characterization of intraheterogeneity

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