Establishment and application of model for screening medicaments for resisting heterogeneous and multi-reason senile dementias

A technology for senile dementia and model building, applied in drug combinations, medical preparations containing active ingredients, medical science, etc., can solve the problems of ignoring the heterogeneity and multifactoriality of senile dementia

Inactive Publication Date: 2009-12-16
JIANGXI UNIVERSITY OF TRADITIONAL CHINESE MEDICINE
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Problems solved by technology

The related AD and VD dementia animal model making has always been one of the difficulties and hotspots in this field. The existing model preparations often strictly separate the two, and most of them only aim at a certain aspect of the pathological characteristics of the disease (i.e. Simulating one aspect of many pathological changes), while ignoring the heterogeneity and multifactoriality of senile dementia

Method used

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  • Establishment and application of model for screening medicaments for resisting heterogeneous and multi-reason senile dementias
  • Establishment and application of model for screening medicaments for resisting heterogeneous and multi-reason senile dementias
  • Establishment and application of model for screening medicaments for resisting heterogeneous and multi-reason senile dementias

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Experimental program
Comparison scheme
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Embodiment Construction

[0007] 1 Establishment of senile dementia model

[0008] 1.1 Experimental grouping

[0009] 55 healthy Wistar rats were randomly divided into 3 groups: blank group, sham injury group and model group. There were 15 rats in the blank group and 20 rats in each experimental group.

[0010] 1.2 Modeling method

[0011] The blank group will not be treated. The model group was given intraperitoneal injection of D-gal (50 mg / kg d) respectively to cause subacute aging, and after 4 weeks, the bilateral common carotid arteries were ligated repeatedly to cause cerebral ischemic lesions (360 mg / kg intraperitoneal chloral hydrate in rats) Inject anesthesia, make an incision after routine disinfection in the middle of the neck, separate the bilateral common carotid arteries, and set the "4" silk thread buckle. Tighten the thread buckle, block the blood flow for 10 minutes, loosen the thread button to allow the blood to perfuse for 10 minutes, and then block again Blood flow was observed ...

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Abstract

The invention relates to the establishment of a model for screening medicaments for resisting heterogeneous and multi-reason senile dementias, which is characterized in that the common carotid arteries on two sides of each group of aging rats are ligated repeatedly to block blood flow, the rats are fed for three days after operations, and the alive rats in good condition are intracerebrally injected with Abeta1-40 (incubated 1 W at a temperature of 37 DEG C) which is diluted to be 5 micrograms per microliter by sterile normal saline. The establishment has the following advantages: by using the model, a damage model of the aging rats with declined learning and memory functions is provided for the studies on the nosogenesis of old age AD, VD and mixed dementias and the correlative curative effect of medicaments, and the model can reflect the actual brain pathology damage conditions of senile dementia patients.

Description

technical field [0001] The invention relates to the establishment and application of a drug screening model for anti-heterogeneity and multifactorial senile dementia. Background technique [0002] The pathogenesis and disease process of senile dementia are complex, and each existing animal model only simulates the symptoms and pathological changes of senile dementia animals to a certain extent or in some aspects. It is extremely difficult and economically unnecessary to find an animal model that can completely simulate all the clinical and pathological features of Alzheimer's disease. Due to the high prevalence of mixed dementia among clinical dementia populations, people combine Alzheimer's disease (AD) with vascular dementia (VD). The related AD and VD dementia animal model making has always been one of the difficulties and hotspots in this field. The existing model preparations often strictly distinguish the two, and most of them only aim at a certain aspect of the patho...

Claims

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Application Information

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IPC IPC(8): A61K31/7004A61P25/28A61B17/12
Inventor 张忠立左月明匡海学
Owner JIANGXI UNIVERSITY OF TRADITIONAL CHINESE MEDICINE
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