51results about How to "No less efficacy" patented technology

The present invention provides compositions and methods of using the compositions to alter the developmental potency of a cell. The present invention provides in vivo and ex vivo cell reprogramming and programming methods suitable for autologous cell therapy and regenerative medicine.

[Problem] As compared with the current oral sustained-release preparation containing tamsulosin hydrochloride which have been supplied to the medical setting, there is a problem to provide a sustained-release pharmaceutical composition in which efficacy is equivalent or even better, adverse events such as adverse reactions (e.g., postural hypotension) are reduced, dose can be increased and, if desired, ingestion of food is not limited. [Means for Resolution] A sustained-release pharmaceutical composition, characterized in that, there are contained tamsulosin or a pharmaceutically acceptable salt thereof and a carrier for a sustained-release pharmaceutical composition and, when dissolution test is carried out according to Japanese Pharmacopoeia Dissolution Test Method 2, the tamsulosin release after 7 hours from the start of the dissolution is about 20 to about 85%.

The present invention provides compounds and assays for the identification and validation of compounds for use in the treatment of spinal muscular atrophy (SMA), in which said compounds up-regulate the post-transcriptional expression of SMN1 or SMN2.

Compositions and methods for controlling molluscs, members of the Gastropoda and Bivalvia classes which includes but is not limited to lactones, lactams, carbamates, amides, and / or carboxylic acid containing compounds as active ingredients and / or compounds derived from Pseudomonas and / or Erwinia. Also provided are methods and compositions for increasing the efficacy of chemical and biological control for invasive molluscs in open waters, power plants, and drinking water treatment facilities under coldwater conditions.

A composition and a method of preparing a transparent / translucent moisturizing / cosmetic / personal cleansing bar having a final water content of about 13% by weight or less, preferably about 7% to about 11% water, thereby increasing the melting temperature of the bar to prevent melting and reduce deformation during storage and handling, increasing its hardness and durability, and substantially reducing the tendency of the bar to lose weight over time by evaporation of water by exposure to room temperature.

Provided herein are peptidomimetic macrocycles containing amino acid sequences with at least two modified amino acids that form an intramolecular cross-link that can help to stabilize a secondary structure of the amino acid sequence. Suitable sequences for stabilization include those with homology to the p53 protein. These sequences can bind to the MDM2 and / or MDMX proteins. Also provided herein are methods of using such macrocycles for the treatment of diseases and disorders, such as cancers or other disorders characterized by a low level or low activity of a p53 protein or high level of activity of a MDM2 and / or MDMX protein.

Compositions and methods for controlling molluscs, members of the Gastropoda and Bivalvia classes which includes but is not limited to lactones, lactams, carbamates, amides, and / or carboxylic acid containing compounds as active ingredients and / or compounds derived from Pseudomonas and / or Erwinia. Also provided are methods and compositions for increasing the efficacy of chemical and biological control for invasive molluscs in open waters, power plants, and drinking water treatment facilities under coldwater conditions.

The present invention provides compounds and assays for the identification and validation of compounds for use in the treatment of spinal muscular atrophy (SMA), in which said compounds up-regulate the post-transcriptional expression of SMN1 or SMN2.

The present invention provides a sustained-release pharmaceutical composition, characterized in that, there are contained tamsulosin or a pharmaceutically acceptable salt thereof and a carrier for a sustained-release pharmaceutical composition and, when a dissolution test is carried out according to Japanese Pharmacopoeia Dissolution Test Method 2, the tamsulosin release after 7 hours from the start of the dissolution is about 20 to about 85%.

The present invention provides compounds and assays for the identification and validation of compounds for use in the treatment of muscular dystrophy (MD), or a form thereof, in which said compounds increase the post-transcriptional expression of a target gene (i.e., mIGF1, ITGA7, or UTRN).

Compositions and methods for controlling molluscs, members of the Gastropoda and Bivalvia classes which includes but is not limited to lactones, lactams, carbamates, amides, and / or carboxylic acid containing compounds as active ingredients and / or compounds derived from Pseudomonas and / or Erwinia. Also provided are methods and compositions for increasing the efficacy of chemical and biological control for invasive molluscs in open waters, power plants, and drinking water treatment facilities under coldwater conditions.

The invention relates to compounds that can be used, in particular, as structural mimetics of proline-rich peptides and are correspondingly able to bond with proline-rich-motif binding domains (PRM domains) of proteins. The invention further relates to the use of these compounds as pharmaceutically active agents, as well as the use of the pharmaceutically active agents for the treatment of bacterial, neurodegenerative and tumor diseases.

The invention relates to a smoke dust hydrator. The smoke dust hydrator comprises a first container, a main gas inlet pipe, a flow splitting chamber, a plurality of gas inlet branch pipes, a first barrel-shaped foam intercepting net, an umbrella-shaped foam intercepting net, first tapered pipes, first dust deposition pipes and a first gas outlet pipe, wherein the main gas inlet pipe penetrates through and is fixedly connected with the top of the first container; the flow splitting chamber is of a hollow cavity and an opening at the top of the flow splitting chamber is connected with the main gas inlet pipe and extends to one end of the inner part of the first container; a plurality of openings are formed in the bottom of the flow splitting chamber and are connected with the upper ends of the plurality of gas inlet branch pipes; the lower ends of the plurality of gas inlet branch pipes are connected with the first barrel-shaped foam intercepting net; the umbrella-shaped foam intercepting net is arranged at the peripheries of the gas inlet branch pipes above the first barrel-shaped foam intercepting net; the lower end of the first barrel-shaped foam intercepting net is connected with an upper-end large opening of the corresponding first tapered pipe and a lower-end small opening of the first tapered pipe is connected with the corresponding first dust deposition pipe; the lower ends of the plurality of first dust deposition pipes are combined and extend to a dust deposition chamber below the first container; and one end of the first gas outlet pipe is fixedly connected with the top of the first container. The smoke dust hydrator has high efficiency of filtering smoke dust, and is complete in purification, low in cost and rapid in effect.

The present disclosure provides a method of treating a subject that is resistant to one or more drugs by identifying a subject having one or more drug resistant cells; administering to the subject a pharmaceutically effective amount of an inhibitor compound, and contacting one or more drug resistant cells with the inhibitor compound to reduce the export of the inhibitor compound from the one or more drug resistant tumor cells and to block the transport of drug(s) from the one or more drug resistant cells.

The invention provides a process for pickling sweet and sour fresh ginger through a two-step method and relates to a processing method for farm produced food. Fresh and tender ginger is selected as a main raw material, cleaned with clear water, subjected to air-drying and skin removal and then cut into ginger slices or shreds, primary pickling auxiliary materials are added, the mixture is stirred to be uniform and pre-pickled in a container, the pre-pickled ginger slices or shreds are put in a storage tank or canned bottles according to rated weight to be compacted, ginger liquid obtained after pre-pickling is filtered out for other use, mature ginger juice is added into the storage tank or the canned bottles to drown the ginger slices or shreds, then secondary pickling auxiliary materials are spread on the surfaces of the ginger slices or shreds, table vinegar is added into the storage tank or the canned bottles in proportion, the storage tank is covered with a sealing cover or the canned bottles are covered with sealing covers, and the sweet and sour fresh ginger is prickled. According to the process, the sweet and sour fresh ginger is prickled in two steps, the ginger liquid, which has a high moisture ratio and is prone to rot, generated during pre-pickling is filtered out, and then the mature ginger juice and the secondary pickling auxiliary materials are added for pickling; as a result, the concentration of effective ingredients is higher, and the sweet and sour fresh ginger is not prone to rot.

The present invention relates to compositions comprising an IL-12 protein having a first and second subunit, an EDB-binding domain, and a linker between the IL-12 protein and the EDB-binding domain.

The methods described herein provide nucleic acid constructs and screening methods for identifying and validating compounds for use in the treatment of cancer, wherein the compounds down-regulate the post-transcriptional expression of Bmi-1.

The present application discloses stability-indicating potency assays for influenza vaccines.

The invention discloses a method for pickling sweet and sour ginger and relates to a processing method of agricultural food products. The method includes: selecting fresh and tender ginger as main raw material, washing the fresh and tender ginger with clean water, airing, peeling, slicing or shredding, adding primary pickling auxiliaries using sugar as the main raw material, well mixing with the sliced or shredded ginger, pre-pickling in a container, filtering ginger juice after the pre-pickling for other purposes, well mixing secondary pickling auxiliaries with the pre-pickled sliced or shredded ginger, feeding into a storage tank or split charging into preserving jars according to rated weight, compacting the sliced or shredded ginger, spreading a layer of sugar on the sliced or shredded ginger, proportionally adding vinegar into the storage tank or the preserving jars, covering with sealing covers, and pickling the sweet and sour ginger. The method has the advantages that the sweet and sour ginger is pickled in two steps, the ginger juice with high moisture proportion and easy to rot obtained during the pre-pickling is filtered, then the secondary pickling auxiliaries are added for pickling, the effective component concentration is high, and the sweet and sour ginger is less prone to rot.

An extract from inflamed skins of rabbits inoculated with vaccinia virus is provided where the quality of the extract is more stabilized. A preparation, etc. containing said extract as an active ingredient is also provided. When the amount of sulfated tyrosine contained in an extract from inflamed skins of rabbits inoculated with vaccinia virus and also contained in a preparation containing said extract as an active ingredient is used as an index, the quality of the extract and the preparation among the manufacturing lots can be warranted as a more stabilized one. In the extract from inflamed skins of rabbits inoculated with vaccinia virus and the preparation containing said extract where the quality thereof is more stabilized by such a method, the efficacy and the safety thereof are now guaranteed more strictly resulting in very high usefulness.

The invention provides a preparation method of sweet and sour fresh ginger and related to a processing method of agricultural foods. The preparation method comprises the following steps: selecting fresh and tender gingers as a main raw material, cleaning fresh and tender gingers with clean water, airing, removing peels, cutting the gingers into ginger slices or shredded gingers, adding a pickling auxiliary material mainly prepared from table sugar, uniformly stirring the pickling auxiliary material with the ginger slices or the shredded gingers to produce a ginger liquid after the auxiliary material is absorbed by the ginger slices or the shredded gingers, and sterilizing or concentrating the produced ginger liquid for later use; after the ginger liquid is filtered, adding the ginger slices or the shredded gingers into a storage can or respectively adding the ginger slices or the shredded gingers into canned bottles, adding the concentrated and sterilized ginger liquid into the storage can or the canned bottles, scattering a layer of table sugar to the surfaces of the ginger slices or the shredded gingers, adding table vinegar into the storage can or the canned bottles in proportion, sealing the storage can or the canned bottles with sealing covers, and carrying out pickling, so as to obtain the sweet and sour fresh ginger. According to the preparation method, the produced ginger liquid is filtered and independently boiled, and the ginger slices or the shredded gingers are not boiled, so that the fresh state of the fresh and tender gingers can be maintained, and the components of the fresh gingers do no run off.

Disclosed herein are methods for treating, ameliorating, and / or preventing Alzheimer's Disease in a specific patient population using tramiprosate, valyl-3-amino-1-propanesulfonic acid, or a pharmaceutically acceptable salt thereof based upon a combination of APOE4 status and disease severity.

Compositions and methods for controlling molluscs, members of the Gastropoda and Bivalvia classes which includes but is not limited to lactones, lactams, carbamates, amides, and / or carboxylic acid containing compounds as active ingredients and / or compounds derived from Pseudomonas and / or Erwinia. Also provided are methods and compositions for increasing the efficacy of chemical and biological control for invasive molluscs in open waters, power plants, and drinking water treatment facilities under coldwater conditions.

It is an object of the present invention to provide an extract from inflamed skins of rabbits inoculated with vaccinia virus wherein the quality is more stabilized, and a preparation containing the extract, etc. The use of the amount of N-acetylneuraminic acid contained in an extract from inflamed skins of rabbits inoculated with vaccinia virus and a preparation containing the extract as an index makes possible to warrant the quality of each manufacturing lot of the extract and the preparation in more stable manner. The extract from inflamed skins of rabbits inoculated with vaccinia virus and the preparation containing the extract which are manufactured as above, and in which the quality thereof becomes more stable, are warranted to maintain efficacy and safety in more strict manner, and thus extremely useful.

The present disclosure provides a method of treating a subject that is resistant to one or more drugs by identifying a subject having one or more drug resistant cells; administering to the subject a pharmaceutically effective amount of an inhibitor compound, and contacting one or more drug resistant cells with the inhibitor compound to reduce the export of the inhibitor compound from the one or more drug resistant tumor cells and to block the transport of drug(s) from the one or more drug resistant cells.

The present invention discloses a slim and aqueous extract of Garcinia cambogia comprising (−)-hydroxycitric acid as dietary product for weight management. The present invention also discloses a process of preparation of aqueous extract wherein the Garcinia cambogia fruit rinds are subjected to cold circulation to retain the phytochemical components and the aqueous extract is adjusted to neutral pH and stabilized with triple mineral salt of calcium, magnesium and potassium and decolorized using activated carbon. The colorless, odorless aqueous extract obtained is subjected to qualitative and quantitative analysis to obtain pure concentrate, which is useful in food, beverage and pharmaceutical industries as dietary supplement. The concentrate equivalent to 1500 mg of (−)-hydroxycitric acid on dried basis is used for the consumption with the distilled water. The slim and aqueous extract concentrate of Garcinia cambogia is useful in treatment of overweight, obesity and hypercholesterolemia.

Disclosed herein are methods for treating, ameliorating, and / or preventing Alzheimers Disease in a specific patient population using tramiprosate, valyl-3-amino-1-propanesulfonic acid, or a pharmaceutically acceptable salt thereof based upon a combination of APOE4 status and disease severity.