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Dose computation for radiation therapy using heterogeneity compensated superposition

A radiation therapy and radiation dose technology, applied in radiation therapy, radiation measurement, X-ray/γ-ray/particle irradiation therapy, etc., can solve problems such as read/write conflicts, inaccurate dose calculation, and difficulty in providing good results

Active Publication Date: 2014-09-24
THE JOHN HOPKINS UNIV SCHOOL OF MEDICINE
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Problems solved by technology

However, it is not feasible to directly partition existing serial algorithms to generate multi-threaded
This is because threads are farmed out to calculate the same radiation dose based on the same input data, which is prone to read / write conflicts
When a write on write (WOW) conflict occurs, for example it may happen that only the last write is stored, resulting in inaccurate dose calculations
Furthermore, traditional methods of performing real-time radiotherapy planning do not provide good results for discontinuities within the irradiated material

Method used

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  • Dose computation for radiation therapy using heterogeneity compensated superposition
  • Dose computation for radiation therapy using heterogeneity compensated superposition
  • Dose computation for radiation therapy using heterogeneity compensated superposition

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[0133] To investigate this parameter space, we use a combination of automated optimization and human graphical inspection. We restrict all parameters except F0 to a small non-negative number, which is limited to ±1 / π. We employ a variety of optimization techniques and objectives. For most optimizations, we summed the squared mean square error as a set of exemplary depth-dose curves. Exemplary examples are ICCR2000, 24MV Water-Lung-Water and 24MV Water-Low Density-Water virtual image studies. These virtual image studies were chosen because they were the most difficult to achieve simultaneously. The error used differs from the traditional gamma metric, which uses percentages rather than absolute dosimetry errors. We use percent error since it does not reduce the error weight in deep or low density materials. We use squared error because it increases the weight of larger errors. We limit the error on average to the target area, 3cm to 17cm, which includes tricky material tra...

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Abstract

A system for radiation therapy includes a radiation planning system. The radiation planning system includes a data processor that is adapted to receive information concerning an intended radiation treatment region of a body, receive a calculated initial energy released per unit mass for a plurality of locations within the body, compute a radiation dose at a plurality of locations within the radiation treatment region based on the calculated initial energy released per unit mass and including radiation dose contributions due to scattering from other locations within the body, and determine radiation therapy parameters for providing radiation treatment to the intended radiation treatment region based on the radiation dose computed at the plurality of locations within the radiation treatment region.; Including radiation dose contributions due to scattering from other locations within the body take into account density discontinuities in the body.

Description

[0001] Cross References to Related Applications [0002] This application claims priority to US Provisional Application No. 61 / 540,773, filed September 29, 2011, the entire disclosure of which is incorporated herein by reference. Background technique [0003] 1. Field of invention [0004] The present invention relates to radiation therapy systems, and more particularly, to radiation therapy systems with non-uniform distribution of radioactive substances. [0005] 2. Discussion of related technologies [0006] Radiation therapy is the medical use of radiation to treat malignant cells, such as cancer cells. This emission can be in electromagnetic form, such as high energy photons, or in particulate form, such as electrons, protons, neutrons or alpha particles. [0007] By far the most common form of emission used in today's practice is the high energy photon. Absorption of photons in human tissue is determined by the energy emitted and the atomic structure of the relevan...

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61N5/00A61N5/10G01T1/161
CPCA61N5/1031A61N5/1039A61B6/58G16H20/40A61N5/103A61N5/1048A61N5/1067A61N5/1071A61N5/1075A61N2005/1032
Inventor 托德·R·麦克纳特罗伯特·阿兰·雅克
Owner THE JOHN HOPKINS UNIV SCHOOL OF MEDICINE
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