Preparation method of long-acting mosquito repellent liquid and long-acting mosquito repellent liquid
A production method and technology for mosquito repellent are applied in skin care preparations, pharmaceutical formulations, cosmetic preparations, etc., and can solve the problems of short duration of mosquito repellent and side effects.
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Embodiment 1
[0019] The preparation method of long-acting mosquito repellent liquid is made by the following steps:
[0020] Get 5 parts by weight of hydroxyethyl piperidine carboxylate isobutyl ester and add in the water of 20 parts by weight to obtain the first solution, the structural formula of hydroxyethyl piperidine carboxylate isobutyl ester is:
[0021] Get 5 parts by weight of lemon eucalyptus oil and add in 20 parts by weight of ethanol to obtain the second solution;
[0022] mixing the first solution with the second solution to obtain a third solution;
[0023] Take 20 parts by weight of Pelargonium geranium and 10 parts by weight of leaves of Artemisia argyi. The water content of geranium geranium and leaf wormwood is not more than 30%. Parts of ethanol aqueous solution, the ethanol aqueous solution is 75% ethanol aqueous solution (v / v), reflux extraction at a constant temperature of 30-40°C and 0.15MPa for 3-4 hours to obtain the fourth solution; heat the fourth solution A...
Embodiment 2
[0028] A long-acting mosquito repellent prepared by any one of the above-mentioned long-acting mosquito repellent preparation methods.
Embodiment 3
[0030] Rat acute oral toxicity test.
[0031] Test sample: Add water to 6 g of the long-acting mosquito repellent solution of Example 1 to 12 mL and mix thoroughly, as a test sample.
[0032] Experimental animals: Wistar rats with a body weight of 160-200 g, 3 males and 3 males in total, 6 Wistar rats, which have been adapted to the laboratory for more than 2 days and have no abnormal health status, are selected.
[0033] Test method: Animals were fasted overnight, and 2ml / only was orally gavaged, observed and recorded the symptoms after gavage, observed continuously for two weeks, and calculated the median lethal dose (LD 50 ).
[0034] Experimental results: No obvious symptoms of poisoning, no deaths. The median lethal dose was not measured, or the acute oral median lethal dose in rats was greater than 5000 mg / kg for males and females.
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