The invention discloses a nanoscale antibacterial mosquito-repelling microcapsule and a preparation method thereof.The antibacterial mosquito-repelling microcapsule is prepared from organic silica sol, a surfactant, chitosan, mosquito-repelling liquid, ethyl alcohol and deionized water, and the thickness of the capsule wall ranges from 0.10 mm to 0.20 mm. According to the preparation method of the nanoscale antibacterial mosquito-repelling microcapsule, the antibacterial mosquito-repelling microcapsule has the advantages that the antibacterial mosquito-repelling microcapsule is prepared from the following raw materials and components including the organic silica sol, the surfactant, the chitosan, the mosquito-repelling liquid, the ethyl alcohol and the deionized water; comprising the following steps: S1, adding quantitative deionized water into a container, controlling the temperature to be 60-80 DEG C, and adding organic silicon sol into the container while continuously stirring the deionized water; chitosan is adopted as a nano wall material, organic silica sol is adopted as a carrier, emulsified mosquito-repelling mixed liquid is wrapped, volatile mosquito-repelling liquid tissue components in the prepared nano-scale antibacterial mosquito-repelling microcapsule cannot be completely dispersed firstly, the surface area is larger, the mosquito-repelling effect is more natural and more durable, and the antibacterial mosquito-repelling microcapsule has a good antibacterial and mosquito-repelling effect. Meanwhile, the preparation method is short in wrapping time and high in wrapping efficiency, the production efficiency is greatly improved, and application and popularization are facilitated.