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Vilazodone hydrochloride softgel and preparation method thereof

A technology for vilazodone hydrochloride and soft capsules, which is applied in the field of soft capsules containing vilazodone hydrochloride and its preparation, and can solve the problems of lack of high affinity

Inactive Publication Date: 2017-04-26
佛山市弘泰药物研发有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Vilazodone hydrochloride (vilazodone) is a new type of antidepressant. Vilazodone hydrochloride binds to serotonin reuptake site with high affinity (Ki=0.1 nM), but binds to norepinephrine (Ki=56 nM ) or dopamine (Ki=37 nM) reuptake sites without high affinity

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] Embodiment 1 vilazodone hydrochloride soft capsule

[0023] Capsule shell: 1.25g gelatin, 0.45g glycerin, 12g water, 0.15g methyl p-hydroxybenzoate.

[0024] Contents: Vilazodone hydrochloride 20mg, polyethylene glycol 400 3g, chitosan 0.25g, hydroxypropyl methylcellulose 0.13g, ascorbic acid 0.1g, methyl paraben 0.05g.

Embodiment 2

[0025] Example 2 Vilazodone Hydrochloride Soft Capsules

[0026] Capsule shell: gelatin 1.35g, glycerin 0.50g, water 1.21g, methylparaben 0.23g.

[0027] Contents: Weigh 20 mg of vilazodone hydrochloride, 4 g of polyethylene glycol 400, 0.25 g of glycerin, 0.1 g of hydroxypropyl methylcellulose, 0.12 g of ascorbic acid, and 0.03 g of methyl p-hydroxybenzoate.

Embodiment 3

[0028] Example 3 Vilazodone Hydrochloride Soft Capsules

[0029] Capsule shell: 1.45g gelatin, 0.60g glycerin, 1.3g water, 0.15g methyl p-hydroxybenzoate.

[0030] Contents: Weigh 40 mg of vilazodone hydrochloride, 4.3 g of polyethylene glycol 400, 0.2 g of chitosan, 0.1 g of hydroxypropyl methylcellulose, 0.10 g of ascorbic acid, and 0.02 g of methyl p-hydroxybenzoate.

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PUM

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Abstract

The invention relates to a preparation method of vilazodone hydrochloride softgel. The vilazodone hydrochloride softgel prepared in the invention has the advantages of good stability and stable properties. The above depression treatment medicine combination has a reasonable ratio, rapidly releases a medicine, and has a very good treatment effect on diseases.

Description

technical field [0001] The invention belongs to the field of pharmaceutical preparations, and relates to a soft capsule containing vilazodone hydrochloride and a preparation method thereof. Background technique [0002] Vilazodone hydrochloride was developed by Trovis Pharmaceuticals LLC of the United States. It is the first indolealkylamine drug for the treatment of severe depression in adults. It is a selective serotonin reuptake inhibitor and a partial stimulator of 5-HT1A receptors. agent double action. In January 2011, the U.S. Food and Drug Administration (FDA) approved vilazodone hydrochloride tablets for the treatment of major depressive disorder (MDD) in adults. The trade name of vilazodone is Viibryd. Vilazodone hydrochloride (vilazodone) is a new type of antidepressant. Vilazodone hydrochloride binds to serotonin reuptake site with high affinity (Ki=0.1 nM), but binds to norepinephrine (Ki=56 nM ) or dopamine (Ki=37 nM) reuptake sites with no high affinity. Vil...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/48A61K31/496A61K47/38A61K47/42A61P25/24
CPCA61K9/4825A61K9/4866A61K31/496
Inventor 雷林芳
Owner 佛山市弘泰药物研发有限公司
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