Vilazodone hydrochloride softgel and preparation method thereof
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A technology for vilazodone hydrochloride and soft capsules, which is applied in the field of soft capsules containing vilazodone hydrochloride and its preparation, and can solve the problems of lack of high affinity
Inactive Publication Date: 2017-04-26
佛山市弘泰药物研发有限公司
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Vilazodone hydrochloride (vilazodone) is a new type of antidepressant. Vilazodone hydrochloride binds to serotonin reuptake site with high affinity (Ki=0.1 nM), but binds to norepinephrine (Ki=56 nM ) or dopamine (Ki=37 nM) reuptake sites without high affinity
Method used
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[0027] Contents: Weigh 20 mg of vilazodone hydrochloride, 4 g of polyethylene glycol 400, 0.25 g of glycerin, 0.1 g of hydroxypropyl methylcellulose, 0.12 g of ascorbic acid, and 0.03 g of methyl p-hydroxybenzoate.
Embodiment 3
[0028] Example 3 Vilazodone Hydrochloride Soft Capsules
[0030] Contents: Weigh 40 mg of vilazodone hydrochloride, 4.3 g of polyethylene glycol 400, 0.2 g of chitosan, 0.1 g of hydroxypropyl methylcellulose, 0.10 g of ascorbic acid, and 0.02 g of methyl p-hydroxybenzoate.
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Abstract
The invention relates to a preparation method of vilazodone hydrochloride softgel. The vilazodone hydrochloride softgel prepared in the invention has the advantages of good stability and stable properties. The above depression treatment medicine combination has a reasonable ratio, rapidly releases a medicine, and has a very good treatment effect on diseases.
Description
technical field [0001] The invention belongs to the field of pharmaceutical preparations, and relates to a soft capsule containing vilazodone hydrochloride and a preparation method thereof. Background technique [0002] Vilazodone hydrochloride was developed by Trovis Pharmaceuticals LLC of the United States. It is the first indolealkylamine drug for the treatment of severe depression in adults. It is a selective serotonin reuptake inhibitor and a partial stimulator of 5-HT1A receptors. agent double action. In January 2011, the U.S. Food and Drug Administration (FDA) approved vilazodone hydrochloride tablets for the treatment of major depressive disorder (MDD) in adults. The trade name of vilazodone is Viibryd. Vilazodone hydrochloride (vilazodone) is a new type of antidepressant. Vilazodone hydrochloride binds to serotonin reuptake site with high affinity (Ki=0.1 nM), but binds to norepinephrine (Ki=56 nM ) or dopamine (Ki=37 nM) reuptake sites with no high affinity. Vil...
Claims
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Application Information
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