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Pharmaceutical composition for treatment of schizophrenia and preparation method and application thereof

A technology for schizophrenia and a composition, applied in the field of medicine, can solve the problems of disease recurrence, the pathogenesis is not completely clear, the patient cannot accept it, etc., and achieves the effects of enhancing immune function, facilitating rehabilitation treatment, and relatively stable curative effect.

Inactive Publication Date: 2017-04-26
郑州莉迪亚医药科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

So far, the pathogenesis of this disease is not fully understood
[0003] People pay more and more attention to the treatment of schizophrenia with the combination of traditional Chinese and western medicine. Long-term use of large doses of western medicine for schizophrenia will inevitably lead to sleep disorders and extrapyramidal side effects, which often lead to unacceptable and unacceptable medication for patients, resulting in relapse

Method used

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  • Pharmaceutical composition for treatment of schizophrenia and preparation method and application thereof
  • Pharmaceutical composition for treatment of schizophrenia and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] In an embodiment of the present invention, a pharmaceutical composition for treating schizophrenia is composed of the following raw materials in parts by weight: 1 part of sucralfate, 7 parts of diclofenac sodium, 3 parts of ambroxol, 11 parts of betulinic acid, 14 parts of ginger.

[0019] Diclofenac sodium is mixed with deionized water whose mass is 12.8 times that of diclofenac sodium to prepare a diclofenac sodium solution. Mix and grind sucralfate, aminotoluic acid, and betulinic acid, add diclofenac sodium solution, and stir at 45°C for 38 minutes to prepare mixture A. The mixture A was ultrasonically treated at a temperature of 58°C for 18 minutes, with an ultrasonic power of 800W, then added alpinol, and subjected to microwave treatment for 5 minutes, with a microwave power of 1000W, then stirred at a temperature of 67°C until dry, and then granulated. pharmaceutical composition.

Embodiment 2

[0021] In an embodiment of the present invention, a pharmaceutical composition for treating schizophrenia is composed of the following raw materials in parts by weight: 5 parts of sucralfate, 15 parts of diclofenac sodium, 7 parts of aminomethylbenzoic acid, 19 parts of betulinic acid, 22 parts of ginger.

[0022] Diclofenac sodium is mixed with deionized water whose mass is 12.8 times that of diclofenac sodium to prepare a diclofenac sodium solution. Mix and grind sucralfate, aminotoluic acid, and betulinic acid, add diclofenac sodium solution, and stir at 45°C for 40 minutes to prepare mixture A. The mixture A was ultrasonically treated at a temperature of 58°C for 18 minutes, with an ultrasonic power of 800W, then added alpinol, and subjected to microwave treatment for 5 minutes, with a microwave power of 1000W, then stirred at a temperature of 67°C until dry, and then granulated. pharmaceutical composition.

Embodiment 3

[0024] In an embodiment of the present invention, a pharmaceutical composition for treating schizophrenia is composed of the following raw materials in parts by weight: 2 parts of sucralfate, 9 parts of diclofenac sodium, 4 parts of aminomethylbenzoic acid, 13 parts of betulinic acid, 16 parts of ginger.

[0025] Diclofenac sodium is mixed with deionized water whose mass is 12.8 times that of diclofenac sodium to prepare a diclofenac sodium solution. Mix and grind sucralfate, aminotoluic acid, and betulinic acid, add diclofenac sodium solution, and stir at 45°C for 39 minutes to prepare mixture A. The mixture A was ultrasonically treated at a temperature of 58°C for 18 minutes, with an ultrasonic power of 800W, then added alpinol, and subjected to microwave treatment for 5 minutes, with a microwave power of 1000W, then stirred at a temperature of 67°C until dry, and then granulated. pharmaceutical composition.

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Abstract

The invention discloses a pharmaceutical composition for treatment of schizophrenia and a preparation method and an application thereof. The pharmaceutical composition consists of the following raw materials in parts by weight: 1-5 parts of sucralfate, 7-15 parts of diclofenac sodium, 3-7 parts of aminomethylbenzoic acid, 11-19 parts of betulinic acid, and 14-22 parts of alpinetin. The preparation method comprises the steps: mixing and grinding sucralfate, aminomethylbenzoic acid and betulinic acid, adding a diclofenac sodium solution, carrying out stirring treatment for 38-40 min at a temperature of 45 DEG C, and carrying out ultrasonic treatment for 18 min at a temperature of 58 DEG C with the ultrasonic power of 800 W; then adding alpinetin, and carrying out microwave treatment for 5 min with the microwave power of 1000 W; and stirring to dry at the temperature of 67 DEG C, and granulating. The pharmaceutical composition has the advantages of good curative effect and relatively stability during schizophrenia treatment, small use amount, no toxic or side effect, stable long-term curative effect and enhanced immune function. The preparation method has the advantages of simple and easily obtained raw materials, simple preparation process, easy operation and low production cost, and is suitable for large-scale popularization.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to a pharmaceutical composition for treating schizophrenia, a preparation method and application thereof. Background technique [0002] Schizophrenia is a group of severe mental illnesses of unknown etiology, mostly in young adults with slow or subacute onset, clinically manifested as a syndrome with various symptoms, involving obstacles in perception, thinking, emotion, and behavior and incoordination of mental activity. Patients generally have clear consciousness and basically normal intelligence, but some patients may experience cognitive impairment during the course of the disease. The course of the disease is generally protracted, showing repeated attacks, aggravation or deterioration, and some patients eventually develop decline and mental disability. Modern antipsychotic drugs, especially classic drugs, have serious side effects, which often lead to the failure of maintena...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/7024A61K31/196A61K31/195A61K31/56A61K31/352A61P25/18
CPCA61K31/7024A61K31/195A61K31/196A61K31/352A61K31/56A61K2300/00
Inventor 不公告发明人
Owner 郑州莉迪亚医药科技有限公司
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