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Pharmaceutical composition as well as preparation method and application thereof

A technology for compositions and medicines, applied in the direction of condensation preparation of carbonyl compounds, antibacterial drugs, glycopeptide components, etc.

Inactive Publication Date: 2017-05-17
XIANGTAN ZHILIAN TECH MATASTASIS PROMOTE CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0009] At present, there are few compounds against vancomycin-resistant bacteria on the market, but the inventor has developed a composition against vancomycin-resistant bacteria, which can be used to prepare drugs for the treatment of vancomycin-resistant bacteria infections

Method used

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  • Pharmaceutical composition as well as preparation method and application thereof
  • Pharmaceutical composition as well as preparation method and application thereof
  • Pharmaceutical composition as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0058] Reaction a prepares compound (formula IA), reacts as follows:

[0059]

[0060] After testing, the compound (formula IA) molecular formula is C 13 h 10 o 4 After testing, the compound (formula IA) obtained in this embodiment is the compound (formula I) provided by the invention:

[0061]

Embodiment 2

[0063] Reaction b prepares compound (formula IA'), reaction is as follows:

[0064]

[0065] After testing, the compound (formula IA') obtained in this example is the same compound as in Example 1, that is, both formula IA and formula IA' are compounds (formula I) provided by the present invention:

[0066]

[0067]

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PUM

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Abstract

The invention discloses a pharmaceutical composition and application thereof. The pharmaceutical composition is a compound expressed in the formula (I) or a pharmaceutically acceptable salt and a pharmaceutically acceptable carrier thereof. The formula (I) is as shown in description. The pharmaceutical composition can be used for preparing antibacterial medicines and can be especially used for preparing medicines for preventing or treating diseases infected by vancomycin-resistant bacteria. Experiment data shows that the compound can be used for effectively inhibiting the growth of vancomycin-resistant enterococcus when the compound is combined with glycopeptides antibacterial medicines.

Description

technical field [0001] The invention relates to a pharmaceutical composition, its preparation method and application, in particular to a pharmaceutical composition, its preparation method and its application on vancomycin-resistant bacteria, and belongs to the field of medicinal chemistry. Background technique [0002] Bacteria (Bacteria) is one of the main groups of organisms, belongs to the domain of bacteria, and is the most numerous type of all organisms. Bacteria are both useful and harmful to the environment, humans and animals. Some bacteria become pathogens, causing various infectious diseases such as tetanus, typhoid, pneumonia, syphilis, cholera, and tuberculosis. In plants, the bacteria cause leaf spot, fire blight and wilting. [0003] In the 1950s and 1960s, known as the "golden age" of antibiotics, about 7 million people died of infectious diseases worldwide every year, and this number rose to 20 million by 1999. In the United States, known as the most techno...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07C49/83C07C45/46A61K31/122A61K38/14A61P31/04
CPCC07C49/83A61K31/122A61K38/14C07C45/46
Inventor 不公告发明人
Owner XIANGTAN ZHILIAN TECH MATASTASIS PROMOTE CO LTD
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