Application of pilose antler extract in preparation of products for preventing and/or treating Parkinson disease

A technology for Parkinson's disease and extract, which is applied in the application field of preparing products for preventing and/or treating Parkinson's disease, and can solve problems such as toxic side effects, little attention to non-motor symptoms, and inability to prevent dopaminergic neuron degeneration, etc. , to achieve a good therapeutic effect

Inactive Publication Date: 2017-05-24
EXPERIMENTAL RES CENT CHINA ACAD OF CHINESE MEDICAL SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the treatment drugs for Parkinson's disease mostly focus on the control of motor symptoms, but pay little attention to the non-motor symptoms and the development process of the whole disease. They cannot prevent the degeneration of dopaminergic neurons, and long-term application has serious toxic side effects , so safe and effective therapeutic drugs are the common needs of the entire human society

Method used

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  • Application of pilose antler extract in preparation of products for preventing and/or treating Parkinson disease
  • Application of pilose antler extract in preparation of products for preventing and/or treating Parkinson disease
  • Application of pilose antler extract in preparation of products for preventing and/or treating Parkinson disease

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0077] Embodiment 1, have the preparation of the velvet antler protein extract of preventing and / treating Parkinson's disease

[0078] 1. Preparation of velvet antler protein extract

[0079] The velvet protein extract is prepared according to the following method, and the velvet protein extract is the velvet protein extract for preventing and / or treating Parkinson's disease. details as follows:

[0080] The fresh velvet antler is directly crushed for the first time with a pulverizer to obtain the first crushed velvet antler. Put the velvet antler crushed for the first time into liquid nitrogen quick-freezing, put it into a superfine pulverizer, add an appropriate amount of water for the second crushing until it is minced meat, and obtain the second crushed velvet antler, the molecular particle size of the second crushed velvet antler is 75 μm. Add a certain amount of water to the second crushed velvet antler (the mass ratio of the second crushed velvet to water is 1:5), th...

Embodiment 2

[0161] Embodiment 2, the pharmacodynamic study of velvet antler protein extract

[0162] 1. Animal modeling

[0163] After intraperitoneal injection of 10% chloral hydrate according to the injection dose of 0.35mL / 100g body weight in rats was anesthetized, sensory loss was induced. Fix the head on the stereotaxic instrument, incise the scalp, remove the subcutaneous tissue and periosteum, and find the anterior and posterior fontanelles. It is determined that the right side of the substantia nigra compact part is 4.8mm posterior to the anterior bregma, 2.0mm to the right of the sagittal suture, and 8.0mm subperiosteum; the ventral tegmental area of ​​the midbrain is 4.8mm posterior to the anterior bregma, 1.2mm to the right of the midline, and 8.0mm subperiosteal mm. After determining the coordinates, inject 8 μL of the prepared 6-OHDA solution into the substantia nigra pars compacta and the ventral tegmental area of ​​the midbrain, and inject in divided doses, and keep the n...

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Abstract

The invention discloses an application of a pilose antler extract in preparation products for preventing and/or treating Parkinson disease. The pilose antler protein extract can alleviate the symptoms of Parkinson disease in model group rats, and increases the number of neuronal cells in a corpus striatum of a brain tissue. The pilose antler protein extract is adopted for treatment of the model group rats, can increase DA, DOPAC and HVA in a rat cerebrospinal fluid and DA and 5-HT in the brain tissue, decreases the content of glutamic acid and gamma-aminobutyric acid in the rat cerebrospinal fluid and the content of glutamic acid in the brain tissue, and decreases the HAV/DA ratio, the DOPAC/DA ratio, the 5-HIAA/5-HT ratio and the glutamic acid/gamma-aminobutyric acid ratio in the rat cerebrospinal fluid and the brain tissue. Pharmacological experiments prove that the pilose antler protein extract has a good therapeutic effect on Parkinson disease animal models, and provides an experimental basis for research and development of new drugs for Parkinson disease.

Description

technical field [0001] The invention relates to the application of deer antler extract in the preparation of products for preventing and / or treating Parkinson's disease. Background technique [0002] Deer antler is a precious medicinal material in traditional Chinese medicine. Together with ginseng and donkey-hide gelatin, it is called the three treasures of traditional Chinese medicine. It has a history of more than 2,000 years of use. "Compendium of Materia Medica" records that velvet antler "generates essence and nourishes marrow, nourishes blood and nourishes yang, and strengthens muscles and bones". It tastes sweet and salty, and is warm in nature. Toxic, warm but not dry, has the effect of stimulating and improving the function of the body, and has a good effect of strengthening the body for patients with general weakness and long-term illness. [0003] Modern pharmacological studies have confirmed that the chemical components in velvet antler are complex, among which...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K35/32A61P25/16
Inventor 王毅孙娅楠李超华张倩马淑骅欧阳竞锋
Owner EXPERIMENTAL RES CENT CHINA ACAD OF CHINESE MEDICAL SCI
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