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A formulated feed for improving intestinal barrier function of early-weaned piglets and its feeding method

A technology of intestinal barrier function and early weaning, applied in animal feed, food processing, animal husbandry, etc., can solve the problem of ineffective intestinal barrier function of early weaned piglets, and achieve the goal of increasing the average daily feed intake and reducing feed intake. weight ratio, and the effect of reducing the rate of diarrhea

Active Publication Date: 2020-10-23
JIANGXI AGRICULTURAL UNIVERSITY +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, single addition of MOS has no obvious effect on alleviating the early weaning stress and improving the intestinal barrier function of early weaning piglets
[0005] From the above, scholars have done a lot of research on the mechanism of Gln and MOS to relieve piglet weaning stress, but there is no combination of Ala-Gln dipeptide and MOS to relieve early weaning stress of piglets and improve early weaning stress. Related reports on intestinal barrier function of piglets

Method used

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  • A formulated feed for improving intestinal barrier function of early-weaned piglets and its feeding method
  • A formulated feed for improving intestinal barrier function of early-weaned piglets and its feeding method
  • A formulated feed for improving intestinal barrier function of early-weaned piglets and its feeding method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] 1.1 Materials and methods

[0034] 1.1.1 Test material

[0035] Mannan Oligosaccharides (MOS) was purchased from Jinan Shenghe Chemical Co., Ltd., with a purity of ≥99%; Alanyl-glutamine (Ala-Gln) was purchased from Shanghai Chaoqiang Chemical Co., Ltd., with a purity of ≥99%. 99%.

[0036] 1.1.2 Experimental animals and group design

[0037] The experiment selected 162 21-day-old weaned piglets with similar genetic background, parity and body weight, and divided them into 9 treatments (control group, treatment 1, treatment 2, treatment 3, treatment 4, treatment 5, treatment 6, Treatment 7, treatment 8), 3 repetitions for each treatment, 6 piglets for each repetition, see Table 1 for details.

[0038] Table 1 Experimental design

[0039] project control group processing 1 processing 2 processing 3 Process 4 Process 5 Process 6 Process 7 Process 8 MOS 0 0.10％ 0.20％ 0 0.10％ 0.20％ 0 0.10％ 0.20％ Ala-Gln 0 0 0 0.15％ 0.1...

Embodiment 2

[0080] Example 2: Effects of Ala-Gln and MOS on Growth Performance and Diarrhea Rate of Weaning Stressed Piglets

[0081] 2.1 Materials and methods

[0082] 2.1.1 Test material

[0083] Mannan Oligosaccharides (MOS) was purchased from Jinan Shenghe Chemical Co., Ltd., with a purity of ≥99%; Alanyl-glutamine (Ala-Gln) was purchased from Shanghai Chaoqiang Chemical Co., Ltd., with a purity of ≥99%. 99%.

[0084] 2.1.2 Experimental animals and group design

[0085] Experimental animals and group design are the same as in Example 1.

[0086] 2.1.3 Test diet and feeding method

[0087] The basic diet composition and feeding method are the same as in Example 1.

[0088] 2.1.4 Feeding management

[0089] The test was carried out in a large breeding pig farm in Jiangxi. The test pigs were raised on nursery beds with high beds, slatted plastic floors, and movable cement troughs. Feed and water were given ad libitum, and fed 4-5 times a day. The immunization and deworming procedu...

Embodiment 3

[0115] Example 3: Comparison of the effects of different Ala-Gln and MOS additions and different basal ration ratios on the daily feed intake and villi height of weaned stressed piglets in different feeding periods

[0116] 3.1 Materials and methods

[0117] 3.1.1 Test material

[0118] Mannan Oligosaccharides (MOS) was purchased from Jinan Shenghe Chemical Co., Ltd., with a purity of ≥99%; Alanyl-glutamine (Ala-Gln) was purchased from Shanghai Chaoqiang Chemical Co., Ltd., with a purity of ≥99%. 99%.

[0119] 3.1.2 Experimental animals and group design

[0120] The experiment selected 108 21-day-old weaned piglets with similar genetic background, parity and weight, and divided them into 4 treatments (treatment 1, treatment 2, treatment 3, treatment 4, treatment 5, treatment 6) in a completely random block. Three replicates were processed, with 6 piglets in each replicate, see Table 1 for details.

[0121] Table 6 Experimental design

[0122]

[0123] 3.1.3 Test diet a...

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Abstract

The invention relates to the technical field of pig feed preparation and particularly discloses a formula feed for improving an intestinal barrier function of an early weaned piglet and a feeding method of the formula feed. The formula feed comprises basal diet and a feed additive; the feed additive comprises MOS occupying 0.10-0.20 percent of the mass percentage of the basal diet and Ala-Gln occupying 0.15-0.30 percent of the mass percentage of the basal diet. When the formula feed disclosed by the invention is used for feeding the early weaned piglet, the average daily feed intake of the weaned stress piglet can be significantly improved, so that the feed-weight ratio of the weaned stress piglet is significantly reduced, the villus height / crypt depth of each of duodenum and ileum is significantly improved, the jejunum crypt depth is significantly reduced, and the diarrhea rate of the weaned stress piglet is significantly reduced; after the weaned piglet is fed for 28 days, an interaction effect on the villus height of the duodenum and the villus height / crypt depth is realized. The formula feed disclosed by the invention is easy for raw material obtaining, simple in preparation method and convenient to use.

Description

technical field [0001] The invention relates to the technical field of pig feed preparation, in particular to a feed preparation for improving the intestinal barrier function of early weaned piglets and a feeding method thereof. Background technique [0002] Modern intensive pig farms have advanced the weaning age of piglets from the original 35d to 70d to 21d to 35d. Early weaning of piglets is a major technical means to tap the production potential of sows and improve the efficiency of pig breeding. However, due to the influence of physiological, nutritional and environmental factors, early weaning is often prone to lead to "piglet early weaning stress syndrome (PWSD)" characterized by intestinal mucosal damage, slow growth or even stagnation, decreased immunity and diarrhea. Pig farming causes huge economic losses. [0003] Weaning stress seriously affects the growth potential of piglets and is closely related to the production efficiency of pig farms. Appropriate measur...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A01K67/02A23K50/30
CPCA01K67/02Y02P60/87
Inventor 游金明陈丽玲王自蕊平伟强邓宸玺
Owner JIANGXI AGRICULTURAL UNIVERSITY
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