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A compound preparation for reducing the diarrhea rate of weaned piglets and its preparation method

A technology for weaned piglets diarrhea and a composite preparation is applied in the field of composite preparations for reducing the diarrhea rate of weaned piglets and the preparation field thereof, which can solve the problems of complex Escherichia coli serotypes, slow efficacy of Chinese herbal medicines, short duration of antibodies, and the like, and achieves reduction of Escherichia coli Quantity, growth-promoting, diarrhea-reducing effects

Active Publication Date: 2018-11-30
山东宝来利来生物工程股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] So far, in the prevention and treatment of weaned piglet diarrhea in China, drugs such as antibiotics are directly injected or added to the feed. With the emergence of a large number of drug-resistant strains, it is often found that the existing chemical drugs are not effective in controlling diarrhea, and these drugs Extensive use of large-scale use may easily cause drug residues in animal products, which will accumulate in the human body and seriously threaten human health; although vaccine immunization can increase the antibody content in sow milk, the duration of the antibody is short, and it is not enough to protect piglets throughout the growth stage Diarrhea does not occur, and the serotype of Escherichia coli is complex and constantly changing, even if the piglets are immunized, there is little effect; Chinese herbal medicines are slow in efficacy, large in dosage, and poor in palatability, which limits their application in weaned piglet diets; high copper, high Trace elements such as zinc are also used, but they are prone to residues, large pollution, and easy to cause heavy metal poisoning; enzyme preparations are also used, but the action point is too single to solve the diarrhea caused by intestinal flora imbalance

Method used

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  • A compound preparation for reducing the diarrhea rate of weaned piglets and its preparation method
  • A compound preparation for reducing the diarrhea rate of weaned piglets and its preparation method
  • A compound preparation for reducing the diarrhea rate of weaned piglets and its preparation method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] Example 1: Screening test of compound acidifier for preventing and treating diarrhea in weaned piglets

[0030] 1 Materials and methods

[0031] 1.1 Experimental design

[0032] The experiment was carried out at the Bafubafu farm in Xiangyin Township, Ningyang County, Shandong Province. 90 weaned piglets of the same breed and similar body weight at the age of 30-33 days were selected and divided into control group (CK), test group I (F1) and Experimental group II (F2), each group has 3 repetitions, and each repetition has 10 pigs. The control group was fed with clear water every day, the test group I was fed with compound acidifier formula 1 (diluted 10 times with water) every day, and the test group II was fed with compound acidulant formula 2 (diluted with water 10 times) every day, and fed continuously for 14 days. After feeding, change to clean water for normal feeding, and then observe for 7 days to carefully observe the diarrhea of ​​pigs.

[0033] Compound aci...

Embodiment 2

[0067] Embodiment 2: Preparation of a compound preparation for reducing the diarrhea rate of weaned piglets

[0068] The compound preparation is formed by mixing oligosaccharide acidifier liquid and probiotic fermented liquid in a volume ratio of 1:4;

[0069] Among them, the oligosaccharide acidulant liquid is compounded by the compound acidulant formula 1 optimized in Example 1 and oligosaccharides, and every 1 mL of the oligosaccharide acidulant liquid contains: 3000 μg of oxalic acid, 50 μg of tartaric acid, malic acid 60μg, 5000μg lactic acid, 3000μg citric acid, 0.1g glucose, 0.05g isomalto-oligosaccharide, 0.05g fructo-oligosaccharide, 0.1g chitosan-oligosaccharide;

[0070] Glucose, isomalto-oligosaccharide, fructo-oligosaccharide and chitosan-oligosaccharide are commercially available products.

[0071] The probiotic fermentation liquid is prepared by mixing the mixed fermentation liquid of Lactobacillus plantarum, Pediococcus pentosaceus and the fermentation liquid ...

Embodiment 3

[0077] Example 3: Validation test of compound preparation for preventing and treating diarrhea in weaned piglets

[0078] 1 Materials and methods

[0079] 1.1 Experimental design

[0080] The test was carried out at the Buff Buff farm in Xiangyin Township, Ningyang County, Shandong Province. 90 weaned piglets of the same breed and similar weight at the age of 30-33 days were selected and divided into control group, test group, and related product groups. Each group 3 replicates with 10 pigs per replicate. The control group drank water and fed clear water every day, the test group drank water and fed the compound preparation prepared in Example 2 (diluted 10 times with water), and the related product group was fed Pushengyuan (diluted 10 times with water), which was purchased from Henan Punier Biopharmaceuticals Ltd.

[0081] 1.2 See Example 1 for experimental diet, management, evaluation, and data analysis.

[0082] 2 Results and Analysis

[0083] 2.1 Effect of compound p...

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Abstract

The invention discloses a compound preparation for reducing the diarrhea rate of weaned piglets, which is formed by mixing an oligosaccharide acidifier liquid and a probiotic fermentation liquid at a volume ratio of 1:(3‑5); every 1 mL of the oligosaccharide The acidulant solution contains: oxalic acid 2500-3500μg, tartaric acid 30-60μg, malic acid 50-100μg, lactic acid 4000-5500μg, citric acid 2500-4000μg, glucose 0.05-0.2g, oligomeric isomaltose 0.05-0.1g, oligomeric Fructose 0.02-0.06g, chitosan oligosaccharide 0.08-0.15g; the probiotic fermented liquid is by volume ratio (2-4) by volume ratio (2-4) :1 mixed. The invention also discloses a preparation method of the compound preparation for reducing the diarrhea rate of weaned piglets. The compound preparation of the invention can reduce the diarrhea probability of weaned piglets, reduce the mortality rate of piglets, and improve the production performance and immune function of piglets.

Description

technical field [0001] The invention relates to a compound preparation for reducing the diarrhea rate of weaned piglets and a preparation method thereof. Background technique [0002] In recent years, my country's pig industry has developed very rapidly, and the management and scale of breeding have been improved. With the improvement of pig production technology, some countries and regions with developed pig farming have gradually popularized early weaning technology for piglets, but premature weaning will cause nutritional, environmental and psychological stress in piglets, resulting in poor feed intake reduction, stunted growth, weight loss, diarrhea, and even death. According to reports, piglets below 30kg have an annual diarrhea incidence rate of 46.5% and a mortality rate of 10.3%. Therefore, how to prevent and treat diarrhea in weaned piglets has become one of the urgent tasks of the current pig industry. [0003] So far, in the prevention and treatment of weaned p...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K35/747A61K35/741A61P1/12A23K10/18A23K20/163A23K50/30A23K50/60
Inventor 单宝龙陈雷谷巍王红孙明杰林显华崔斌王军徐鹏董佩佩王春凤
Owner 山东宝来利来生物工程股份有限公司
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