New composition for preventing gastrointestinal disorders

A technology of composition and use, applied in the field of colic and/or constipation, treatment/prevention of esophageal reflux, treatment of slow transit constipation, and can solve the problems of undisclosed, transit time dysfunction, etc.

Active Publication Date: 2017-05-31
NV NUTRICIA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0010] However, none of the above prior art documents disclose that the composition (f) or the food product comprising uridine derivatives and butyrate-producing fibers can provide beneficial effects on constipation, transit time dysfunction, colon length disturbance and / or such Composition or food can be used to improve stool consistency

Method used

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  • New composition for preventing gastrointestinal disorders
  • New composition for preventing gastrointestinal disorders
  • New composition for preventing gastrointestinal disorders

Examples

Experimental program
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Effect test

example 1

[0124] Constipation, the most important and debilitating non-motor symptom of Parkinson's disease (PD), was induced in mice by intrastriatal injection of 2.7 μg of rotenone via stereotaxic access to the brain. Previous epidemiological studies have demonstrated that exposure to this pesticide induces Parkinson's disease (PD). In addition to the observed constipation, intrastriatal injections with rotenone also resulted in the well-known motor symptoms of PD, evidenced by the impaired ability of mice to remain on a moving rotarod (see figure 1 ). Rotary pole treadmills consist of a plastic pole with a non-slip surface above the base (stop ram). Mice were placed on an accelerating rod, the speed starting at 2 rpm and gradually increasing to 20 rpm. The rodent's ability to remain on the rotarod (time to first fall) was recorded for a maximum of 5 min. Prior to baseline, train mice with the rotarod apparatus to rule out learning effects throughout the experimental period.

example 2

[0126] The effect of a diet comprising a pyrimidine derivative (UMP) and a source of PUFA (DHA) was studied in a treatment setting, wherein the dietary treatment according to the invention was started 4 weeks after injection of 5.4 μg of rotenone or vehicle and continued for 7 weeks . Six experimental groups of male C57B1 / 6J mice were used, in which vehicle (sham group) or rotenone treatment was used, and in which received a control diet or a diet according to the invention (diet 1 or diet 2), as shown in the table below:

[0127] Table 1: Experimental groups

[0128]

[0129] The composition of the control and active diets is shown in the table below.

[0130] Table 2: Composition of the diet

[0131]

[0132]

[0133] 1 Butyrate-producing fiber (5g / 100g diet):

[0134] 1.50 g of GOS

[0135] 0.17g of long-chain FOS

[0136] 1.67g of short-chain FOS

[0137] 1.67g of nutriose

[0138] And another 0.5g of lactose and 0.5g of carbohydrates and water to 7.27g

...

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PUM

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Abstract

The present invention provides for a composition comprising a uridine source and butyrate producing fibers for use in the prevention or treatment of constipation, transit time dysfunction or colon length disorder. Said composition may also be used for the improvement of stool consistency. Advantageously said composition further comprises omega-3 polyunsaturated fatty acids such as DHA and / or EPA and a vitamin supplement comprising at least vitamin D3.

Description

Background technique [0001] The present invention relates to a novel composition for preventing or treating gastrointestinal diseases, preferably a food or feed composition comprising a uridine derivative and a dietary fiber, preferably a butyrate-producing fiber. The term GI disorders includes a broad group of different conditions ranging from appendicitis, intestinal obstruction, colitis, Crohn's disease, peptic ulcer to anal fistula, including enhanced or impaired motility of the gastrointestinal tract (GIT) (too fast in diarrhea, too slow in slow transit constipation), and changes in the contractility of the rectal sphincter (resulting in fecal incontinence or fecal impaction / refractory constipation). In the present invention, in particular, the composition is active against constipation, transit time dysfunction, colon length disorder, and can be used to improve stool consistency. [0002] Constipation is a common cause of painful bowel movements. Severe constipation in...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/7072A61K31/202A61K31/593A61K31/702A61P25/00A61P25/02A61P25/16A61P25/24A61P1/10
CPCA61K31/202A61K31/593A61K31/702A61K31/7072A61P1/10A61P25/00A61P25/02A61P25/16A61P25/24A61K2300/00
Inventor 阿莫斯·阿塔利
Owner NV NUTRICIA
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