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Application of arctigenin to preparation of anti-depression product

A technology of arctigenin and anti-depression, applied in the field of medicine, can solve the problems that arctigenin has yet to be developed, and achieve the effects of reducing the incubation period of ingestion, increasing the preference value of sugar water, and reducing the central residence time

Inactive Publication Date: 2017-06-13
HEBEI MEDICAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the application of arctigenin in antidepressant drugs has yet to be developed

Method used

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  • Application of arctigenin to preparation of anti-depression product
  • Application of arctigenin to preparation of anti-depression product
  • Application of arctigenin to preparation of anti-depression product

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0039] Example 1 The source of arctigenin.

[0040] The arctigenin described in the present invention is a monomer isolated and extracted from Arctium Fructus, provided by Shanghai Yuanye Company, with a purity of more than 98% through identification.

Embodiment 2

[0041] Example 2 Experimental model of acute stress in mice.

[0042] As the experimental animals, male ICR mice were used. The mice had free access to food and water, and their body weight was about 30-40 grams during the experiment.

[0043] Quantitative arctigenin was placed in a 10ml centrifuge tube, and quantitative 0.5% dimethyl sulfoxide solution was added to dissolve it, and then quantitative saline was added; the positive control drug was fluoxetine. The way of administration is intraperitoneal injection.

[0044] Mice were randomly divided into 5 groups, divided into normal group, negative control group (vehicle group), arctigenin low-dose group (10mg / kg), arctigenin high-dose group (30mg / kg), each group 10 Only.

[0045] like figure 1 As shown, the mice began to be administered after 5 days of adaptive feeding, and the day of the first administration was counted as the first day of administration, and the administration was continued for 14 days, and the behavior...

Embodiment 3

[0046] Embodiment 3 mouse behavior experiment model

[0047] 3.1 The forced swimming test, the sugar water preference test, the new environment suppression ingestion test, and the opening test are all the same as the behavioral detection methods in Example 2.

[0048] Forced swim test and sugar water preference test. The experimental results are: arctigenin has a significant antidepressant effect. Compared with the vehicle control group, continuous intraperitoneal injection of 10mg / kg for 14 days can significantly reduce the total immobility time of mice (p figure 2 Said; 14 days of continuous intraperitoneal injection administration of 30mg / kg can significantly increase the sugar water preference value of mice and significantly increase (p image 3 shown. Compared with the positive control group, there was no significant difference in the arctigenin administration group, indicating that arctigenin can significantly reduce the floating time of mice in acute stress and increase ...

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Abstract

The invention discloses application of arctigenin to the preparation of an anti-depression product. Arctigenin can be applied to preparation of the anti-depression product, particularly drugs, can effectively treat or prevent depression and has a remarkable anti-depression effect. Moreover, arctigenin, as a traditional Chinese medicine natural plant extract, has higher safety and adaptability to a human body, causes little side effects on the human body, can be used for a long time and has a creative significance on study of depression prevention.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to a new application of arctigenin, that is, its application in the preparation of antidepressant drugs, food and the like. Background technique [0002] Depression is a kind of mental illness caused by a variety of reasons, and the main symptom is low mood. Its clinical manifestations are diverse. Depression is a common psychiatric disease. According to a report titled "Depression: A Global Crisis" released by the World Health Organization in 2012, depression has become the second largest disease burden in China and is expected to rise to The burden of disease in the world ranks first. According to China Military Net citing the World Health Organization, there are currently about 350 million depressed patients worldwide. It is estimated that in the coming year, 5.8% of men and 9.5% of women will have depressive symptoms, and more than 70% of them will have obvious depressive sym...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/365A61P25/24A23L33/105
CPCA23V2002/00A61K31/365A23V2250/21A23V2200/322
Inventor 史海水尹希杜玉茹
Owner HEBEI MEDICAL UNIVERSITY
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