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Dendrobium loddigesii rolfe extract and anti-diabetic application thereof

A technology of the extract of Dendrobium candidum, applied in the field of Dendrobium candidum extract and its application in anti-diabetic drugs and food, can solve the problems of unproven anti-diabetic effect and unstable acquisition

Active Publication Date: 2017-06-13
SUN YAT SEN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

It has been disclosed in the literature that some monomers extracted from Dendrobium candidum have certain α-glucosidase inhibitory activity, but these monomers are not the main components of Dendrobium candidum, the acquisition is unstable, and the anti-diabetic effect in vivo is not good. can be confirmed

Method used

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  • Dendrobium loddigesii rolfe extract and anti-diabetic application thereof
  • Dendrobium loddigesii rolfe extract and anti-diabetic application thereof

Examples

Experimental program
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Embodiment 1

[0016] Example 1 - Preparation of Herb Dendrobium Extract of the present invention

[0017] Take the dried Dendrobium loddigesii Rolfe, crush it, weigh 1000g and place it in a container, and use V 丙酮 :V 水 = 8:1 acetone-water solution cold soaking 3 times, soaking for 5 days for the first time, soaking for 1 day each for the second and third times, ultrasonic-assisted extraction was used during the soaking period, and 10 times the acetone-water solution was used each time, and filtered , take the filtrate, recover acetone, and concentrate under reduced pressure to obtain 55 g of dry extract. Dissolve the dried extract of Dendrobium candidum with an appropriate amount of methanol, put the sample on a column volume of 10cm x 40cm (i.d.) C-18 reverse-phase silica gel column, and then wash with water, 70%, 80%, 90%, and 100% methanol in sequence The amount of each gradient was 5 column volumes, and 70% and 80% methanol eluents were collected, spin-dried under reduced pressure to ...

Embodiment 2

[0018] Example 2 - Preparation of Herb Dendrobium Extract of the present invention

[0019] The preparation of the dry extract of Dendrobium candidum is the same as in Example 1. Dissolve the dry extract of Dendrobium candidum with an appropriate amount of ethanol, put the sample on the column volume of 10cm´100cm (i.d.) D101 macroporous adsorption resin adsorption column, and then wash with water, 70%, 80%, 90%, and 100% ethanol in sequence The dosage of each gradient solvent is 3 column volumes, and the 70%~90% ethanol elution part is collected to obtain the extract of Dendrobium candidum.

Embodiment 3

[0020] Embodiment 3 - the preparation of the extract of Herb Dendrobium of the present invention

[0021] The preparation of the dry extract of Dendrobium candidum is the same as in Example 1. Dissolve the dry extract of Dendrobium candidum with appropriate amount of methanol, put the sample on the MCI GEL resin adsorption column with a column volume of 10cm x 80cm (i.d.), and then elute with water, 70%, 80%, 90%, and 100% methanol in sequence, The amount of each gradient solvent was 3 column volumes, and the 70%-90% methanol eluted fraction was collected to obtain the extract of Dendrobium cyclamen.

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Abstract

The invention relates to a dendrobium loddigesii rolfe extract and anti-diabetic application thereof. The dendrobium loddigesii rolfe extract is obtained by quenching stems of dendrobium loddigesii rolfe into an acetone water solution and separating and purifying an extract through resin. An experiment proves that the dendrobium loddigesii rolfe extract has significant hypoglycemic activity, and can be used for treatment and healthcare of diabetes. The invention further provides an anti-diabetic pharmaceutical composition and a health food containing the dendrobium loddigesii rolfe extract.

Description

technical field [0001] The invention belongs to the technical field of medicines, and in particular relates to an extract of Dendrobium cyclamen and its application in antidiabetic medicines and food. Background technique [0002] Traditional Chinese medicine has a long history of thousands of years in treating diabetes in my country, and has the advantage of less toxicity than Western medicine. Dendrobium is commonly used in traditional Chinese medicine to treat fever, fluid injury, dry mouth and polydipsia, insufficient stomach yin, lack of food and retching, persistent deficiency of heat after illness, hyperactivity of fire due to deficiency of yin, bone steaming, fatigue and heat, blurred vision, and flaccidity of muscles and bones embolism. It has been reported that co-decoction of Dendrobium and multi-flavored traditional Chinese medicine has definite curative effect on reducing blood sugar, blood lipid and insulin resistance in patients with type II diabetes. Dendro...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/8984A61P3/10A23L33/105
CPCA61K36/8984A61K2236/333A61K2236/55A23V2002/00
Inventor 王军林永成胡海燕陈慧萍
Owner SUN YAT SEN UNIV
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