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A pharmaceutical composition for treating corneal epithelial injury comprising ngf

A corneal epithelium and composition technology, which is applied in the field of medicine to achieve the effects of less adverse reactions, promotion of proliferation, and promotion of clone formation ability

Active Publication Date: 2022-07-26
PEKING UNIV THIRD HOSPITAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, no report has been found containing NGF alone or in combination with other active ingredients for repairing corneal epithelial damage

Method used

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  • A pharmaceutical composition for treating corneal epithelial injury comprising ngf
  • A pharmaceutical composition for treating corneal epithelial injury comprising ngf
  • A pharmaceutical composition for treating corneal epithelial injury comprising ngf

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0040] Example 1 eye drops

[0041] Prepare eye drops according to the preparation method known in the art, and its main components and contents are as follows:

[0042]

Embodiment 2

[0043] Example 2 eye drops

[0044]Prepare eye drops according to the preparation method known in the art, and its main components and contents are as follows:

[0045]

Embodiment 3

[0046] Example 3 eye drops

[0047] Prepare eye drops according to the preparation method known in the art, and its main components and contents are as follows:

[0048]

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PUM

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Abstract

The invention discloses a pharmaceutical composition containing NGF for treating corneal epithelial damage, the pharmaceutical composition containing NGF (preferably of human origin). The pharmaceutical composition of the present invention (preferably in the form of eye drops) can not only promote the proliferation and clone formation ability of corneal limbal stem cells, but also effectively promote the damage and repair of corneal epithelium, including the repair of persistent corneal epithelium damage, the treatment of diabetic keratopathy Treatment, treatment of neurokeratitis, treatment of limbal stem cell deficiency.

Description

technical field [0001] The present invention relates to the technical field of medicine, in particular to a pharmaceutical composition containing NGF for treating corneal epithelial damage. Background technique [0002] The transparency and functional integrity of the cornea depend on the normal structure and metabolism of each layer of the cornea, and the corneal epithelial tissue in the outermost layer undoubtedly plays a very important role in this. Various physical damage, chemical damage, mechanical damage, pathogenic microorganisms, endocrine and immune factors can lead to corneal epithelial damage. The corneal epithelium is a physical barrier against the invasion of external pathogenic factors. The maintenance of its integrity depends on the tight junctions and anchoring junctions between epithelial cells, cells and the basement membrane, and the continuous self-renewal of epithelial cells. Damage to the corneal epithelial layer can affect the connection between cell...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K38/18A61K38/17A61P27/02
CPCA61K38/1793A61K38/185A61K9/0048A61K2300/00
Inventor 齐虹高彩凤
Owner PEKING UNIV THIRD HOSPITAL
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