A cobalt-based coordination compound with antitumor activity

Abstract

The invention discloses a cobalt-based coordination compound with anti-tumor activity. The chemical formula of the cobalt-based coordination compound with anti-tumor activity is [Co(C7H3NO4)(C10H8N2)Cl]*C2H5OH; the molecular weight is 462.74; the cobalt-based coordination compound is of a one-dimenstional structure, and belongs to monoclinic system; space group is P2<1> / n; single cell parameters a=10.898(2) angstroms, b=17.125 (3) angstroms, c=11.412(2) angstroms, alpha=gamma=90 DEG, beta=105.29(3) DEG, V=2054.3(7) angstrom<3>, and Z=4. The cobalt-based coordination compound is prepared taking CoCl<2>*6H<2>O, 2,6-pyridinedicarboxylic acid, and 2,2'-dipyridyl as raw materials via normal-temperature solution volatilization method. The preparation method is simple; cost is low; the obtained cobalt-based coordination compound possesses excellent inhibition effect on chronic granulocytic leukemia cell strain K562 and esophageal carcinoma cell strain OE-19, and it is promising to prepare anti-tumor drugs from the cobalt-based coordination compound.

Description

technical field [0001] The invention belongs to the field of coordination compound preparation, and in particular relates to a cobalt-based coordination compound with antitumor activity, a preparation method and application thereof. Background technique [0002] Coordination compounds, referred to as complexes, usually refer to a class of highly regular infinite network structures formed by metal ions (central atoms) and adjacent ions or molecules (organic ligands) through coordination bonds. bit polymer. Due to the diversity of composition and the controllability of structure, the research content of the synthesis, properties, structure and bonding of coordination compounds is very rich. Organo-metal complexes not only combine the unique characteristics of both inorganic metal ions and organic ligands, but also exhibit more excellent and diverse properties than pure inorganic materials and pure organic supramolecular materials. In the past two or three decades, complexes ...

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Problems solved by technology

Chemotherapy drugs such as cisplatin have serious adverse reactions, such as nephrotoxicity, neurotoxicity, bone marrow suppression, etc. However, the use of such drugs still appears in the treatment plan of more than 50% of cancer patients

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