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A cobalt-based coordination compound with antitumor activity

A technology for coordination compounds and anti-tumor activity, which is applied in the field of coordination compound preparation and achieves the effects of good in vitro inhibitory activity, good promotion significance and simple operation.

Inactive Publication Date: 2019-06-18
FUJIAN MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Chemotherapy drugs such as cisplatin have serious adverse reactions, such as nephrotoxicity, neurotoxicity, bone marrow suppression, etc. However, the use of such drugs still appears in the treatment plan of more than 50% of cancer patients

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  • A cobalt-based coordination compound with antitumor activity
  • A cobalt-based coordination compound with antitumor activity
  • A cobalt-based coordination compound with antitumor activity

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Embodiment Construction

[0018] In order to make the content of the present invention easier to understand, the technical solutions of the present invention will be further described below in conjunction with specific embodiments, but the present invention is not limited thereto.

[0019] Put 2.05 mmol 2,6-pyridinedicarboxylic acid and 1.2 mmol 2,2’-bipyridine into a beaker, add 10 mL deionized water, stir and mix for 15 min, then add 1.2 mmol CoCl 2 •6H 2 O solids were mixed, and 5 mL of absolute ethanol was added, and stirred at room temperature for 3 hours to obtain a light green clear solution, which was filtered, and the filtrate was left to evaporate at room temperature for 1 week, and green diamond-shaped crystals were precipitated, which were then filtered and dried to obtain Cobalt-based coordination compounds [Co(C 7 h 3 NO 4 )(C 10 h 8 N 2 )Cl]•C 2 h 5 OH, the yield is about 55% (calculated as Co).

[0020] 1. [Co(C 7 h 3 NO 4 )(C 10 h 8 N 2 )Cl] •C 2 h 5 Characterization o...

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Abstract

The invention discloses a cobalt-based coordination compound with anti-tumor activity. The chemical formula of the cobalt-based coordination compound with anti-tumor activity is [Co(C7H3NO4)(C10H8N2)Cl]*C2H5OH; the molecular weight is 462.74; the cobalt-based coordination compound is of a one-dimenstional structure, and belongs to monoclinic system; space group is P2<1> / n; single cell parameters a=10.898(2) angstroms, b=17.125 (3) angstroms, c=11.412(2) angstroms, alpha=gamma=90 DEG, beta=105.29(3) DEG, V=2054.3(7) angstrom<3>, and Z=4. The cobalt-based coordination compound is prepared taking CoCl<2>*6H<2>O, 2,6-pyridinedicarboxylic acid, and 2,2'-dipyridyl as raw materials via normal-temperature solution volatilization method. The preparation method is simple; cost is low; the obtained cobalt-based coordination compound possesses excellent inhibition effect on chronic granulocytic leukemia cell strain K562 and esophageal carcinoma cell strain OE-19, and it is promising to prepare anti-tumor drugs from the cobalt-based coordination compound.

Description

technical field [0001] The invention belongs to the field of coordination compound preparation, and in particular relates to a cobalt-based coordination compound with antitumor activity, a preparation method and application thereof. Background technique [0002] Coordination compounds, referred to as complexes, usually refer to a class of highly regular infinite network structures formed by metal ions (central atoms) and adjacent ions or molecules (organic ligands) through coordination bonds. bit polymer. Due to the diversity of composition and the controllability of structure, the research content of the synthesis, properties, structure and bonding of coordination compounds is very rich. Organo-metal complexes not only combine the unique characteristics of both inorganic metal ions and organic ligands, but also exhibit more excellent and diverse properties than pure inorganic materials and pure organic supramolecular materials. In the past two or three decades, complexes ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07F15/06A61P35/00A61P35/02
CPCC07F15/065
Inventor 孙伟明康杰李祥辉郭林峰
Owner FUJIAN MEDICAL UNIV
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