50results about How to "Synthetic method is economical" patented technology

The invention discloses a preparation method and an application for phosphine-oxazoline ligand, and ionic metal complex, enantiomer or racemate thereof. The ligand and the ionic metal complex thereof have the following structural formulas. The phosphine ligand related by the invention employs biphenyl as a skeleton, and realizes completely transmission from planar chirality to axial chirality through an asymmetric desymmerization. The synthetic method is simple and economic, omits a common and complex chiral separation process in the preparation of the chiral ligand. The obtained chiral ligand has the advantages of high reactive activity, good enantiomorphous selectivity and the like in a model reaction.

The invention discloses a phosphine ligand and an enantiomer or a racemic body thereof and preparation methods and applications thereof. The structural formulae of the phosphine ligand and the enantiomer or the racemic body are shown in the specifications; a phosphine ligand compound has a novel framework; complete transfer of planar chirality to axial chirality in a synthesis process is realized through a desymmetrization reaction; a synthesis method is simple and economical; during preparation of a chiral ligand, common complex chiral splitting processes are avoided; and an obtained chiral ligand has the advantages of high reaction activity, high enantioselectivity and the like in a model reaction, can be applied to catalytic reactions of a plurality of metals such as palladium, rhodium, nickel, copper, iridium, ruthenium, iron, cobalt, gold, platinum and the like, and can have a very good catalytic effect.

The invention provides a method for synthesizing carbon quantum dots on the basis of amino acids and iron ions, belonging to the field of preparation of fluorescent nano materials. The method comprises the following steps: oscillating and mixing a mixed solution of iron nitrate and amino acid in a mole ratio of 1:(5-10), and heating to react in an 80-DEG C water bath; and after the reaction finishes, naturally cooling to room temperature, dialyzing and filtering to obtain the carbon quantum dot water solution. The added iron nitrate can enhance the fluorescence intensity of the carbon quantum dots synthesized from tryptophan; and particularly, it is detected that only iron ions have such effects at present. By using accessible tryptophan as the carbon source, the iron ions are doped on such basis to synthesize the high-fluorescence carbon quantum dots. The synthesis method is controllable, simple and economical.

The invention relates to the field of chemical catalysis and discloses a phosphoramidite ligand as well as a preparation method and an application thereof. The synthesized phosphoramidite ligand and an enantiomer or a racemate of the phosphoramidite ligand take biphenyl as a framework and are subjected to an asymmetric induced reaction of axial chirality to realize complete transfer from central chirality to axial chirality. A synthetic method for the phosphoramidite ligand and the enantiomer or the racemate of the phosphoramidite ligand is simple and economic, and a common and complex chiral resolution process is avoided during chiral ligand preparation. The phosphoramidite ligand and the enantiomer or the racemate of the phosphoramidite ligand is employed to form the ligand together with active metal-iridium for catalyzing an asymmetric addition reaction of N-protected isatin and arylboronic acid, a very good catalytic effect is achieved, and a product can obtain the yield of more than 96% and the enantiomeric excess (ee) value of more than 92%.

The invention relates to sanguinarine derivatives and a synthesis method and use thereof. In the invention, 5-isopropoxy-5,6-dihydrosanguinarine, 5-p-methylphenylamino-5,6-dihydrosanguinarine and 5-benzylamino-5,6-dihydrosanguinarine are synthesized by using sanguinarine as a raw material under different conditions. The bactericidal activities of the three compounds are measured at different concentrations, and corresponding EC50 values are calculated. Compared with the conventional bactericide, the sanguinarine derivatives have the characteristics of high degradability, low residue and the like and can be synthesized by a simple and economic method. Thus, the sanguinarine derivatives are valuable bactericide pilot compounds and can be used for preventing and controlling rhizoctonia solani.

The invention relates to a practical synthetic method for 3, 5-disubstituted pyrazole, and the method solves the defects of long reaction time, large consumption of alkyne, low yield and being difficult to synthesize great amount of compounds of the existing method. The technical proposal is as follows: aldehyde compounds which are dissolved into a solvent react with sulfonyl hydrazine compounds, thus obtaining diazo compounds, then the diazo compounds react with alkyne under alkali and the 3, 5-disubstituted pyrazole is obtained. The method is characterized in that the solvent is toluene, the mol ratio of the aldehyde compounds and the sulfonyl hydrazine compounds in the first step of the reaction is 1; the alkali added in the second step is NaOH aqueous solution, the content of NaOH has the same valent weight with the hydrazine; 1.5 valent weight of diazo compounds are added in the third step, and pure target product is obtained by conventional processing after the reaction.

The invention relates to a green method of enzymatic synthesis of cefaclor. The method includes the steps of: (S1) adding a parent nucleus 7-ACCA into a buffer liquid; (S2) under the pH of 5-8, adding a D-p-hydroxyphenylglycinate derivative or a salt thereof and/or D-p-hydroxyphenylglycine amide, and immobilized cefaclor synthesis enzyme, and performing a reaction for 1-3 h at 5-30 DEG C under the pH value of 6.2-7.8; after a certain reaction time, adding a seed crystal to perform crystallization, and when the reaction is finished, separating a reaction liquid and the immobilized cefaclor synthesis enzyme to obtain a cefaclor coarse product; and (S3) acid-hydrolyzing and dissolve-clarifying the coarse product, filtering and re-crystallizing the product to prepare the cefaclor. The enzymatic synthesis method, compared with a conventional chemical synthesis method, is simple in operation, is low in cost, reduces synthetic period, improves production efficiency and total yield, has strong controllability and satisfies industrial production.

The invention discloses a heterogeneous core-shell g-C3N5@MnO2 complex, which takes rod-like g-C3N5 as an inner core, wherein MnO2 nanosheets are compounded on the surface of the inner core, and the heterogeneous core-shell g-C3N5@MnO2 complex has excellent photocatalytic performance and photoelectrocatalytic performance. The invention also discloses a preparation method of the heterogeneous core-shell g-C3N5@MnO2 complex, wherein the method comprises the following steps: uniformly mixing rod-like g-C3N5, KMnO4 and water, transferring the obtained mixed solution into a polytetrafluoroethylenereaction kettle, sealing the polytetrafluoroethylene reaction kettle, and carrying out hydrothermal reaction in a vacuum drying oven; and cooling the reaction kettle to room temperature, washing the obtained reaction solution with water, centrifuging to remove the supernatant, and drying the obtained dark brown precipitate to obtain the heterogeneous core-shell g-C3N5@MnO2 complex. The preparationmethod has the characteristics of simple operation, low cost, environmental protection, no need of complex post-treatment steps, no need of additional addition of a reducing agent, easiness in large-scale preparation and the like.

The invention discloses a synthetic method of pyroglutamyl small peptide, relates to a synthetic method of pyroglutamyl small peptide and provides a synthetic method of pyroglutamyl small peptide which has low-price and easily obtained raw materials, high productivity, simple post treatment and is more suitable for large-scale production. 10mmol of pyroglutamyl diketopiperazine, 20 to 30mmol of amino acid or small peptide and 20 to 30mmol of alkaline organic solvent are added into a container which has a volume of 25mL and is provided with a reflux condensing pipe; the mixture is stirred at the temperature of 0 DEG C to 70 DEG C, reacts for a night, and then undergoes vacuum concentration and then column chromatography and purification to obtain the pyroglutamyl small peptide with the productivity of 20 percent to 85 percent.

The invention relates to application of 3-acetyl thiotetronic acid derivatives in bactericides for controlling phytopathogen. 3-acetyl thiotetronic acid is used as a raw material for synthesizing 3-acetyl-4-benzylidene thiotetronic acid, 3-acetyl-5-p-fluoro-benzylidene thiotetronic acid and 3-acetyl-5-p-trifluoromethyl benzylidene thiotetronic acid under different conditions. The bactericidal activities of the three compounds under different concentrations are measured and the corresponding EC50 values are computed. The 3-acetyl thiotetronic acid derivatives have superior activities in inhibiting bacteria of apple rot, leaf spot of corn, wheat scab and fusarium wilt of tomatoes, have the characteristics of easy degradation, low residual and the like as compared with traditional bactericides, have simple and economic synthetic methods, are lead compounds of bactericides of great value, and can be used for controlling apple rot, leaf spot of corn, wheat scab and fusarium wilt of tomatoes.

The invention discloses an axial chirality monophosphine ligand in chiral bridging and a preparation method thereof. An optical pure ligand which has both chiral chains in bridging and axial chirality is obtained by using biphenyl as a framework through accurate chiral recognition and control, a synthesis method is simple and economic, separation and purification can be realized through a silica-gel column chromatography separation method, a complicated chiral resolution process is avoided, and the obtained chiral ligand has the advantages of high reaction activity, good enantioselectivity and the like in an investigative model reaction; particularly, the effect in an asymmetric Suzuki reaction of palladium-catalyzed bromo-heterocyclic aromatic and arylboronic acid is excellent.

The invention discloses a manganese-based coordination compound with anti-tumor activity. The chemical formula of the manganese-based coordination compound with anti-tumor activity is [Mn(C7H3NO4)*H2O; the molecular weight is 244.04; the manganese-based coordination compound is of a zero-dimenstional structure, and belongs to monoclinic system; space group is C2/c; single cell parameters a=13.214(3) angstroms, b=9.7286 (19) angstroms, c=13.174(3) angstroms, alpha=gamma=90 DEG, beta=96.35(3) DEG, V=1683.2(6) angstrom<3>, and Z=8. The manganese-based coordination compound is prepared taking manganese acetate tetrahydrate and 2,6-pyridinedicarboxylic acid as raw materials via hydrothermal method. The preparation method is simple; cost is low; the obtained manganese-based coordination compound possesses excellent inhibition effect on chronic granulocytic leukemia cell strain K562 and esophageal carcinoma cell strain OE-19, and it is promising to prepare anti-tumor drugs from the manganese-based coordination compound.

The invention discloses a synthesis method of an N-diarylmethyl sulfonamide compound, and belongs to the technical field of organic synthesis intermediates. According to the synthesis method, the N-diarylmethyl sulfonamide compound is synthesized by utilizing a cascade reaction; the method specifically comprises the following steps: (1) adding an aromatic aldehyde, a sulfonamide, trimethoxybenzeneor a derivative thereof, and Lewis acid into a reaction tube according to a molar ratio of 1.0: 1.0: 1.0: 0.1, and carrying out magnetic stirring reaction at room temperature for 8-24 hours by taking1, 2-dichloroethane as a solvent; and (2) after the reaction is finished, evaporating under reduced pressure to remove most of the solvent, and carrying out column chromatography separation and purification on a residual mixed solution by using petroleum ether and ethyl acetate in a volume ratio of (1: 1)-(2: 1) as leacheate to obtain the product. The N-diarylmethyl sulfonamide compound synthesized by the method has wide application in the fields of medicines, pesticides and the like. The synthesis method disclosed by the invention has the advantages of low cost, simplicity in operation, highyield, mild conditions and the like, and has a good application prospect.

The invention discloses a synthesis method of indanone and derivatives thereof, which comprises the following steps: adding a dialkyl acetylene compound, a palladium catalyst, an additive and an inorganic base into a dry reaction container together, and replacing a gas atmosphere in the reaction container with carbon monoxide from air; adding an o-bromoiodobenzene compound and an anhydrous 1,4-dioxane solvent in a carbon monoxide gas atmosphere, heating to react, and cooling to room temperature; adding a saturated ammonium chloride solution for quenching reaction, adding water, extracting by using ethyl acetate, separating by column chromatography, and purifying to obtain indanone and derivatives thereof. The reaction raw materials are easy to obtain, and the reaction conditions are mild;according to the method, the defects that in a traditional preparation method, the raw materials are complex in structure and not easy to obtain and can be obtained through multiple steps are overcome, carbon monoxide serves as a direct source of carbonyl, three new C-C bonds are built in one reaction, and the method better conforms to the ideas of atom economy, synthesis step economy and green chemistry in organic synthesis.

The invention discloses a Schiff base compound, preparation thereof and an application of the Schiff base compound in copper ion detection. The preparation of the Schiff base compound comprises the steps of subjecting 3-benzothiazolyl-2-hydroxyl-5-bromobenzaldehyde and tri(hydroxymethyl)aminomethane, which are in the mole ratio of 1: (1 to 1.5), to heating refluxing for 10 to 15 hours in anhydrousmethanol at the temperature of 60 DEG C to 70 DEG C, carrying out suction filtration after the reaction ends, and washing solids, thereby obtaining the Schiff base compound. Schiff base test paper isobtained through dissolving the obtained Schiff base compound in a DMSO solvent, then, soaking filter paper in a DMSO solution, and carrying out drying. The Schiff base test paper is used for detecting copper ions in an aqueous solution, the sensitivity is high, the result is clear and recognizable, the operation is simple, convenient and quick, special instrument and equipment and professional training are not required, and thus, the popularization is facilitated.