Preparation method for orange red fluorescent copper nanocluster based on L-methionine

Abstract

The invention provides a preparation method for an orange red fluorescent copper nanocluster based on L-methionine. The preparation method comprises the following steps that by taking L-methionine asa protective agent and copper salt as a metal precursor, hydrogen peroxide is added to serve as an activating agent, hydrazine hydrate serves as a reducing agent, an orange red fluorescent copper nanocluster (Cu NCs) with good stability is prepared, the maximum excitation wavelength is 337 nm, the maximum emission wavelength is 592 nm, the stokes shift is up to 255 nm, and the structure is denotedas Cu NCs / Met. The synthetic method is novel, economical and easy to implement. According to the fluorescence quenching phenomenon, the Cu NCs / Met can be used as a fluorescent nanometer probe and isapplied to high-sensitivity and high-selectivity detection of norfloxacin medicines, and the detection process is simple and rapid. The fluorescent nanocluster prepared by the method has huge application prospects in the fields of sensing, catalysis, photoelectric devices, anti-counterfeiting, cell imaging, drug delivery and the like.

Description

technical field [0001] The invention belongs to the field of preparation and application of fluorescent metal nanoclusters, and specifically relates to a new method for preparing L-methionine-based orange-red fluorescent copper nanoclusters and its analysis application. Background technique [0002] Metal nanoclusters (NCs) refer to relatively stable aggregates composed of several to hundreds of metal atoms (Au, Ag, Pt, Pd, Cu, etc.) as the core under the protection of a certain molecular shell. Its size is ultra-small, the particle size is generally less than 2nm, close to the Fermi wavelength of electrons, and has discrete electronic energy level states and molecular-like properties. As a new type of fluorescent nanomaterial, due to its good biocompatibility, The unique electronic, optical, and chemical properties have attracted extensive attention from the research community, and they have shown attractive application prospects in the fields of intracellular fluorescence ...

AI Technical Summary

Problems solved by technology

L-methionine, also known as methionine, is the only sulfur-containing essential amino acid among the amino acids required for animal growth. It plays an important role in animals. However, using the amino acid molecule L-methionine as a protective agent, The synthesis and application of orange-red fluorescent copper nanoclusters with large Stokes shift have not been reported yet

There is only one related study, that is, our research group reported in 2016 that a copper nanocluster with blue-green fluorescence was synthesized by using L-methionine as a template and a reducing agent by heating in a water bath. However, its synthesis The temperature needs to be controlled at 90°C during the process, and the Stokes shift of the product is small, which limits the further application of the product, and related research is still very challenging.

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