Phosphine ligand and enantiomer or racemic body thereof and preparation methods thereof

Abstract

The invention discloses a phosphine ligand and an enantiomer or a racemic body thereof and preparation methods and applications thereof. The structural formulae of the phosphine ligand and the enantiomer or the racemic body are shown in the specifications; a phosphine ligand compound has a novel framework; complete transfer of planar chirality to axial chirality in a synthesis process is realized through a desymmetrization reaction; a synthesis method is simple and economical; during preparation of a chiral ligand, common complex chiral splitting processes are avoided; and an obtained chiral ligand has the advantages of high reaction activity, high enantioselectivity and the like in a model reaction, can be applied to catalytic reactions of a plurality of metals such as palladium, rhodium, nickel, copper, iridium, ruthenium, iron, cobalt, gold, platinum and the like, and can have a very good catalytic effect.

Description

technical field The invention belongs to the field of chemical catalysis, and specifically relates to a class of phosphine ligands or their enantiomers or their racemates and a preparation method thereof. Background technique In asymmetric reactions, the design and synthesis of chiral catalysts with high enantioselectivity and catalytic activity are key. The design and synthesis of chiral catalysts is actually mainly the design and synthesis of chiral ligands, because they play a decisive role in the reactivity and enantioselectivity in transition metal-catalyzed asymmetric reactions [Noyori, R.; Ohkuma, T.Angew.Chem.Int.Ed.2002, 41, 2008], it can be said that the development of asymmetric catalysts is mainly reflected in the development of chiral ligands. From the perspective of chiral elements, there are central chirality, planar chirality, axial chirality and spiral chirality, etc.; from the number of coordination atoms, they can be divided into single-dentate, double-de...

AI Technical Summary

Problems solved by technology

However, compared with BINAP-like bidentate phosphine ligands, the number and types of such ligands are insufficient, and the skeleton (mostly binaphthyls) and spatial structure are relatively single