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An iron-based coordination compound with antitumor activity

A technology of coordination compounds and anti-tumor activity, which is applied to iron group organic compounds without C-metal bonds, iron organic compounds, anti-tumor drugs, etc., to achieve good in vitro inhibitory activity and simple synthesis method.

Inactive Publication Date: 2019-05-21
FUJIAN MEDICAL UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Chemotherapy drugs such as cisplatin have serious adverse reactions, such as nephrotoxicity, neurotoxicity, bone marrow suppression, etc. However, the use of such drugs still appears in the treatment plan of more than 50% of cancer patients

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  • An iron-based coordination compound with antitumor activity
  • An iron-based coordination compound with antitumor activity
  • An iron-based coordination compound with antitumor activity

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Embodiment Construction

[0018] In order to make the content of the present invention easier to understand, the technical solutions of the present invention will be further described below in conjunction with specific embodiments, but the present invention is not limited thereto.

[0019] Put 2.05 mmol 2,6-pyridinedicarboxylic acid and 1.2 mmol 1,10-phenanthroline into a beaker, add 15 mL deionized water, stir and mix for 15 min, then add 1.2 mmol FeCl 3 •6H 2 O solid, continue stirring at room temperature for 3 hours to obtain a reddish-brown clear solution, filter the solution, and the filtrate is left to evaporate at room temperature for 2 weeks, and then reddish-brown massive crystals are precipitated, and then filtered and dried to obtain the iron-based coordination compound [Fe (C 7 h 3 NO 4 )(C 12 h 8 N 2 ) • H 2 O]•2H 2 O single crystal with a yield of 65% (calculated as Fe).

[0020] 1. [Fe(C 7 h 3 NO 4 )(C 12 h 8 N 2 ) • H 2 O]•2H 2 Characterization of O single crystals

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Abstract

The invention discloses an iron-based coordination compound with anti-tumor activity. The chemical formula of the iron-based coordination compound with anti-tumor activity is [Fe(C7H3NO4)(C12H8N2)*H2O]*2H2O; the molecular weight is 455.21; the iron-based coordination compound is of a zero-dimensional structure, and belongs to monoclinic system; space group is P2(1) / c; single cell parameters a=7.8226(16) angstroms, b=27.730(6) angstroms, c=9.2886(19) angstroms, alpha=gamma=90 DEG, beta=106.84(3) DEG, V=1928.5(7) angstrom<3>, and Z=4. The iron-based coordination compound is prepared taking 2,6-pyridinedicarboxylic acid, 1,10-phenanthroline, and FeCl<3>*6H<2>O solid as raw materials via normal-temperature solution volatilization method. The preparation method is simple; cost is low; the obtained iron-based coordination compound possesses excellent inhibition effect on chronic granulocytic leukemia cell strain K562 and esophageal carcinoma cell strain OE-19, and it is promising to prepare anti-tumor drugs from the iron-based coordination compound.

Description

technical field [0001] The invention belongs to the technical field of preparation of coordination compounds, and in particular relates to an iron-based coordination compound with antitumor activity and its preparation method and application. Background technique [0002] Coordination chemistry is an important branch of inorganic chemistry, which was proposed and established by Swiss chemist Werner in 1893. Since Werner won the Nobel Prize in Chemistry in 1913, the theory of coordination chemistry has gradually matured after more than a hundred years of development, especially the crystal field theory, coordination field theory, molecular orbital theory and valence bond theory. Given a reasonable explanation, coordination chemistry has always been a frontier field in inorganic chemistry research, providing a good theoretical basis for the development of complexes on novel functional materials. Due to the diversity of composition and the controllability of structure, the res...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07F15/02A61P35/00A61P35/02
CPCC07B2200/13C07F15/025
Inventor 康杰孙伟明李祥辉郭林峰
Owner FUJIAN MEDICAL UNIV
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