4-aminopyrimidine compound, its preparation method and medical application

A technology of aminopyrimidines and compounds, which can be used in pharmaceutical formulations, antipyretics, drug combinations, etc., and can solve the problem of few types of BTK inhibitors
CN107043366BActive Publication Date: 2020-05-26CHINA PHARM UNIV
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
CHINA PHARM UNIV
Publication Date
2020-05-26

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Abstract

The present invention relates to the field of medicines, and specifically relates to a 4-aminopyrimidine compound having a structural feature represented by formula (I), or pharmaceutically acceptable salts thereof, a preparation method for the compound, and a use of the compound and the salts as a Bruton tyrosine kinase (BTK) inhibitor. A result of experiments shows that the compound in the present invention has a significant inhibition effect on the BTK, and can be used for treating thromboembolism, inflammatory disorders, autoimmune diseases, Waldenstrom macroglobulinemia, B cell lymphomas, and other diseases.
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Description

technical field

[0001] The invention belongs to the field of medicines, and in particular relates to a 4-aminopyrimidine compound or a pharmaceutically acceptable salt thereof, a preparation method thereof, and their use as Bruton's tyrosine kinase inhibitors.

[0002] technical background

[0003] Bruton's tyrosine kinase (BTK) is a member of the Tec family of non-receptor tyrosine protein kinases. It consists of 659 amino acids and contains multiple domains, such as Pleckstrin homology (PH) domain, Tec homology (TH ) domain, Src homology 3 (SH3) domain, SH2 and SH1 domains (Future Med Chem, 2014, 6(6):675-695). Studies have shown that BTK, as an important part of the B cell receptor (BCR) signal transduction pathway, plays an extremely important role in many physiological processes such as the development, maturation, differentiation and proliferation of B cells (Nature, 1993, 361 (6409 ):226-233).

[0004] Precise regulation of BTK is crucial to maintain the normal physi...

Claims

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