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Low-toxicity bioconversion extract as well as preparation method and application thereof

A biotransformation and extraction technology, applied in the digestive system, drug combination, pharmaceutical formula, etc., can solve the problems of high toxicity and achieve low cost, enhanced drug efficacy, and easy operation

Inactive Publication Date: 2017-10-24
CHUXIONG MEDICAL COLLEGE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0004] Polygonum multiflorum is known as the four major nourishing medicinal materials. It is one of the bulk Chinese medicinal materials commonly used in my country and one of the main export medicinal materials. Therefore, clinically, the dosage will be controlled. This is because Polygonum multiflorum contains anthraquinone derivatives, which can promote intestinal peristalsis and laxative, and are highly toxic.

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  • Low-toxicity bioconversion extract as well as preparation method and application thereof

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preparation example Construction

[0016] The preparation method of the present invention comprises the following steps:

[0017] A. Pre-treatment: Weigh the raw materials of Radix Polygoni Multiflori, break and mix to obtain material a;

[0018] B. Extraction: add water 10 to 15 times the weight of material a to material a for ultrasonic extraction to obtain extract b;

[0019] C. Transformation: add cellulase 1 / 4 times the weight of material a to the extract b, then adjust the pH value of the extract b to 5.1~5.3, enzymatic hydrolysis for 46~50 hours, and the enzymatic hydrolysis temperature is 58~62°C , to obtain the conversion solution c.

[0020] The extraction temperature of the ultrasonic extraction is 55-65°C.

[0021] The extraction time of the ultrasonic extraction is 0.5~1.5h.

[0022] The ultrasonic power of the ultrasonic extraction is 25KHz.

[0023] After step C, post-processing is also included, and the post-processing is to concentrate, dry, pulverize and sieve the conversion liquid c.

[...

Embodiment 1

[0030] A. Pre-treatment: Weigh the raw materials of Radix Polygoni Multiflori, break and mix to obtain material a;

[0031] B. Extraction: add water 10 times the weight of material a to material a for ultrasonic extraction, the extraction temperature is 55°C, the extraction time is 0.5h, and the ultrasonic power is 25KHz to obtain extract b;

[0032] C. Transformation: add cellulase 1 / 4 times the weight of material a to the extract b, then adjust the pH value of the extract b to 5.1, enzymolysis for 46 hours, and the enzymolysis temperature is 58°C, to obtain the transformation solution c, That's it.

Embodiment 2

[0034] A. Pre-treatment: Weigh the raw materials of Radix Polygoni Multiflori, break and mix to obtain material a;

[0035] B. Extraction: add water 15 times the weight of material a to material a for ultrasonic extraction, the extraction temperature is 65°C, the extraction time is 1.5h, and the ultrasonic power is 25KHz to obtain extract b;

[0036] C. Transformation: add cellulase that is 1 / 4 times the weight of material a to the extract b, then adjust the pH value of the extract b to 5.3, enzymolyze for 50 hours, and enzymolyze at 62°C to obtain conversion liquid c, That's it.

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Abstract

The invention discloses a low-toxic biotransformation extract and its preparation method and application. The preparation method includes pretreatment, extraction and transformation. The low-toxic biotransformation extract is prepared according to the preparation method. The application described is the application of the low-toxicity biotransformation extract in the treatment / prevention of liver and kidney deficiency, qi and blood deficiency diseases. The method of the present invention can not only increase the total anthraquinone content of Radix Polygoni Multiflori, but also effectively reduce the content of combined anthraquinone, while enhancing the efficacy of Radix Polygonum multiflorum extract, it can reduce its gastrointestinal toxicity and reduce gastrointestinal adverse reactions. The preparation method of the present invention also It has the advantages of easy operation and low cost.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicine, and in particular relates to a low-toxic biotransformation extract and a preparation method thereof. Background technique [0002] At present, in modern society, people study and work at a fast pace, and they are in a stressful environment for a long time. Nocturnal nocturnal emission and other symptoms, and in recent years, many teenagers even have premature graying of their beard and hair, which leads to listlessness, fatigue, and developmental delay over time. [0003] Due to the bad eating habits of people in modern society, long-term intake of excessive high-fat food, excess energy is stored in the form of fat, blood sugar and blood lipid concentrations are high for a long time, and hyperlipidemia is formed over time. Hyperlipidemia used to be common in middle-aged and elderly people, and it has also become younger in recent years. If hyperlipidemia occurs in the heart...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/704A61P1/14A61P1/08A61P25/20A61P29/00A61P15/00A61P17/00A61P3/06
CPCA61K36/704A61K2236/15A61K2236/19A61K2236/331
Inventor 陈珍黄福荣马春霓李佳莉黄文亮丁重帅昝雪峰代玉文杨先振
Owner CHUXIONG MEDICAL COLLEGE
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