Pharmacokinetic parameter estimation method based on contrast agent enhancement curve

A technology of pharmacokinetics and contrast agents, which is applied in calculation, electrical digital data processing, special data processing applications, etc., can solve the problems of time-consuming, laborious arterial input function, arterial input function susceptible to noise interference, secondary perfusion, etc. , to achieve the effects of short peak arrival time, small stationarity index, and narrow half-peak width

Inactive Publication Date: 2017-11-03
PEKING UNIV
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Problems solved by technology

[0005] The existing methods for estimating pharmacokinetic parameters have the following two defects: firstly, it is time-consuming and laborious to obtain the arterial input function, and the acquired arterial input function is easily affected by noise interference and contrast agent reperfusion; secondly, the traditional In order to obtain stable pharmacokinetic parameters, the pharmacokinetic model often simplifies the two-compartment model, such as ignoring the vascular volume fraction, ignoring the influence of contrast agent reflux, etc. Therefore, the traditional pharmacokinetic model for the characterization of physiological metabolism has certain limitations

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  • Pharmacokinetic parameter estimation method based on contrast agent enhancement curve
  • Pharmacokinetic parameter estimation method based on contrast agent enhancement curve
  • Pharmacokinetic parameter estimation method based on contrast agent enhancement curve

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[0031] Estimation of pharmacokinetic parameters based on magnetic resonance dynamic enhanced image sequences, the following combination figure 1 The flow chart of obtaining the arterial input function curve further illustrates the present invention, so as to better understand the technical solution of the present invention. Proceed as follows:

[0032] 1. Preset the seed point of the blood vessel area to obtain the local area of ​​the blood vessel position, such as figure 2 As shown in (a), the Otsu threshold algorithm is used to segment the local area of ​​the blood vessel, and the blood vessel area can be obtained as figure 2 As shown in (b), the contrast agent enhancement curve corresponding to the blood vessel area is screened, and the evaluation index for screening is M, which is defined as follows:

[0033]

[0034] Among them, PV represents the peak value of the contrast medium enhancement curve, TTP represents the peak time of the contrast medium enhancement cur...

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Abstract

The present invention relates to a pharmacokinetic parameter estimation method based on the contrast agent enhancement curve, relates to the field of physiological parameter estimation, and discloses a regularized multi-blind-channel parameter estimation method. The method comprises the following steps: 1) using an arterial input function curve feature to automatically select the arterial input function curve; 2) using a contrast agent enhancement curve feature to cluster the global contrast agent enhancement curve to obtain three types of typical contrast agent enhancement curves; and 3) designing the regularized multi-blind-channel parameter estimation method according to the three typical contrast agent enhancement curves obtained in step 2), and estimating a pharmacokinetic parameter inverse flow coefficient; and 4) using the two-compartment model to estimate other pharmacokinetic parameters of vascular permeability, space volume fraction, and vascular volume fraction.

Description

technical field [0001] The invention relates to a method for estimating pharmacokinetic parameters based on a contrast agent enhancement curve, belonging to the field of physiological parameter estimation. Background technique [0002] Early diagnosis of tumors is the key to improving the survival rate and quality of life of patients, increasing the cure rate, and reducing mortality. During the growth, invasion, and dissemination of tumors, neovascularization is often accompanied. At present, many research works combine contrast agent-enhanced images with pharmacokinetic models to analyze the permeability of tumor microvessels and obtain functional parameters with biological markers. [0003] For the existing pharmacokinetic parameter estimation methods, there are two defects: first, it is time-consuming and laborious to obtain the arterial input function, and the obtained arterial input function is easily affected by noise interference and contrast agent reperfusion; Secon...

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G06F19/00
Inventor 曹亚王慧慧王霄英张珏方竞
Owner PEKING UNIV
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