Purpose of lachnum melanin serving as blood fat-reducing medicament

A blood lipid-lowering drug and the technology of Trichomonas granulosa, applied in the direction of drug combinations, medical preparations containing active ingredients, and pharmaceutical formulas, can solve the problems of use restrictions and achieve significant functions, convenient administration, simple and economical methods

Inactive Publication Date: 2018-01-12
HEFEI UNIV OF TECH
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  • Description
  • Claims
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Problems solved by technology

Although antihyperlipidemic drugs show rapid lipid-lowering effect and good efficacy, the use of these drugs is limited due to

Method used

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  • Purpose of lachnum melanin serving as blood fat-reducing medicament
  • Purpose of lachnum melanin serving as blood fat-reducing medicament
  • Purpose of lachnum melanin serving as blood fat-reducing medicament

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Experimental program
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Embodiment Construction

[0018] 1. Preparation of intracellular melanin LM of Trichomonas granulosa YM226

[0019] Trichodia granulosa YM226 (the strain number is derived from the literature Structural characterization, molecular modification and hepatoprotective effect of melanin from LachnumYM226 on acute alcohol-induced liver injury in mice. Food & Function, 2016, 7 (8): 3617-3627) was inoculated in 100L Fermentation tank, medium composition: 1.0mmol / L tyrosine, 1.1mmol / L copper ion, 25.0g / L glucose, 5.0g / L yeast extract, 5.0g / L peptone, pH 8.0, culture temperature 27℃, The volume ratio of the loading coefficient is 0.7, the inoculum size is 5% (v / v), the ventilation rate is 1.0L / min, and the stirring speed is 180r / min. After 10 days of fermentation, the fermentation liquid is filtered with suction, the mycelium is collected, dried at 50°C, and pressed The mass (g) of mycelium and sodium hydroxide (mL) with a concentration of 1 mol / L (mL) are mixed at a ratio of 1:100, extracted at room temperature...

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Abstract

The invention discloses a purpose of lachnum melanin, namely the application in preparation of a blood fat-reducing medicament. The lachnum melanin is the intracellular melanin LM of lachnum YM226. Pharmacological experiments prove that the LM can effectively reduce the body weight of a high-fat mouse; the levels of TC (Total Cholesterol), TG (Triglyceride) and LDL-C (Low Density Lipoprotein Cholesterin) in the serum and the liver and an AI (Atherogenic Index) of the mouse can be effectively reduced; meanwhile, the HDL-C level is improved; in addition, the activity of antioxidant enzyme SOD (Superoxide Dismutase), GHS-PX (Glutathione Peroxidase), HL (Hepatic Lipase) and LPL (Lipoprotein Lipase) in the serum and the liver of the mouse is remarkably improved by the LM; the content of MDA (Malondialdehyde) is reduced; moreover, the levels of ALT (Alanine Transaminase), AST (Aspartate Transaminase), ALP (Alkaline Phosphatase), CRE (Cre Recombinas), BUN (Blood Urea Nitrogen) and Uric acid are reduced. The LM improves liver and kidney dysfunction caused by hyperlipidemia, shows a remarkable effect on reducing blood fat, does not have a toxic or side effect, can be used for preparing theblood fat-reducing medicament, and is prepared into various preparations according to conventional preparation methods in pharmaceutics, so as to be convenient to take.

Description

technical field [0001] The invention belongs to the technical field of the application of Trichomonas melanin in preparation of medicines, and in particular relates to the use of Trichodia granulosa intracellular melanin (abbreviated as LM) as a blood lipid-lowering drug. Background technique [0002] Melanin is a biological pigment ubiquitous in most biological systems, and has biological and pharmacological properties such as anti-oxidation, anti-radiation, anti-cancer, liver damage protection, regulation of gastrointestinal health, and immune regulation. For example, China's "Food Science" (2009, 30 (17): 185-189) and "Chinese Journal of Food Science" (2012, 12 (10): 62-66) respectively introduced Trichomonas melanin and squid ink melanin as anti- Use of oxidizing substances. "Microbiology Bulletin" (2014,41(2):334-343) introduced that bacterial melanin has the functions of anti-ultraviolet radiation and scavenging free radicals. In recent years, our research group has ...

Claims

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Application Information

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IPC IPC(8): A61K36/062A61P3/06A61K31/404
Inventor 叶明石芳杨柳青李井雷陈婷婷叶子扬
Owner HEFEI UNIV OF TECH
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