Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Prucalopride sccinate tablet and preparation method thereof

A technology of prucalopride and succinic acid, applied in the field of medicine, can solve the problems of low labor efficiency, high equipment requirements, cumbersome process, etc., and achieves the effect of solving the problems of material fluidity and mixing uniformity, and solving the instability of raw materials

Inactive Publication Date: 2018-01-16
SHIJIAZHUANG NO 4 PHARMA
View PDF5 Cites 2 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0012] The purpose of the present invention is to solve the problems that in the existing prucalopride succinate tablet technology, lactose is used in wet granulation to produce adducts; dry granulation has high requirements for equipment, complicated process and low labor efficiency

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Prucalopride sccinate tablet and preparation method thereof
  • Prucalopride sccinate tablet and preparation method thereof
  • Prucalopride sccinate tablet and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] (1) Prescription (1000 tablets):

[0035]

[0036] (2) Preparation method:

[0037] ① Weigh the prescription amount of prucalopride succinate, lactose T100 and optimized microcrystalline cellulose 50 and mix them uniformly in a three-dimensional mixer to obtain mixture 1. (When mixing for 10min, 20min and 30min, take samples to measure the content, and calculate the mixing uniformity)

[0038] ② Add magnesium stearate to mixture 1, blend, tablet, coat and pack.

Embodiment 2

[0040] (1) Prescription (1000 tablets):

[0041]

[0042] (2) Preparation method:

[0043] ① Weigh the prescription amount of prucalopride succinate, lactose T80 and optimized microcrystalline cellulose 50 and mix them uniformly in a three-dimensional mixer to obtain mixture 1. (When mixing for 10min, 20min and 30min, take samples to measure the content, and calculate the mixing uniformity)

[0044] ② Add magnesium stearate to mixture 1, blend, tablet, coat and pack.

Embodiment 3

[0046] (1) Prescription (1000 tablets):

[0047]

[0048]

[0049] (2) Preparation method:

[0050]① Weigh the prescription amount of prucalopride succinate, lactose T100 and optimized microcrystalline cellulose 90 and mix them uniformly in a three-dimensional mixer to obtain mixture 1.

[0051] ② Add magnesium stearate to mixture 1, blend, tablet, coat and pack.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
particle sizeaaaaaaaaaa
particle sizeaaaaaaaaaa
particle sizeaaaaaaaaaa
Login to View More

Abstract

The invention provides a prucalopride sccinate tablet and a preparation method thereof. The prucalopride sccinate tablet comprises prucalopride sccinate, with the weight of 0.5 to 2.0 percent of the total weight of the preparation, particle lactose or spray-dried lactose, with the weight of 65 to 94 percent of the total weight of the preparation, microcrystalline cellulose and / or a compound thereof, with the weight of 5 to 30 percent of the total weight of the preparation, and a lubricant, with the weight of 0.5 to 3 percent of the total weight of the preparation. The method adopts a direct powder mixing tabletting method, and the preparation technology comprises the following steps: (1), uniformly mixing the prucalopride sccinate, lactose and microcrystalline cellulose, so as to obtain amixture I, and (2), adding the lubricant to the mixture I, totally blending, tabletting, coating and packaging.

Description

technical field [0001] The invention belongs to the technical field of medicines, in particular to a prucalopride succinate tablet and a preparation method thereof. Background technique [0002] Chronic constipation has become a global chronic public health problem, especially among adult women and the elderly. It not only seriously affects the quality of life of patients, but may also induce other serious diseases, such as anorectal disease, fecal ulcer and hepatic encephalopathy, etc. , and increase the risk of cardiovascular events, the danger cannot be ignored. [0003] Prucalopride Succinate is a dihydrobenzofuran carboxamide compound, chemical name: 4-amino-5-chloro-2,3-dihydro-N-[1-(3- Methoxypropyl)-4-piperidinyl]-7-benzofurancarboxamide succinate, molecular formula: C18H26ClN3O3·C4H6O4. Its structural formula is: [0004] [0005] The drug is a selective, high-affinity 5-hydroxytryptamine (5-HT4) receptor agonist with intestinal prokinetic activity. The resul...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/28A61K31/4525A61K47/38A61K47/26A61P1/10
Inventor 殷殿书赵晓雷张洪昌刘少倩陈雪桃刘芳菊张玉红杨帆牛虹卫
Owner SHIJIAZHUANG NO 4 PHARMA
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com