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Method for improving safety of compound radix ilicis pubescentis injection solution

A technology of hair holly and injection, applied in the field of medicine, to achieve high safety, reduce the probability and risk of adverse reactions, and achieve good safety effects

Inactive Publication Date: 2018-02-06
CHENGDU SHENGSHI GUANGHUA BIOTECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the compound Maodongqing injection produced in China has also added private plate 80 as a co-solvent, facing the same problem

Method used

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  • Method for improving safety of compound radix ilicis pubescentis injection solution
  • Method for improving safety of compound radix ilicis pubescentis injection solution
  • Method for improving safety of compound radix ilicis pubescentis injection solution

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021]

[0022] Preparation method: Boil holly holly and mountain silver flower with water twice, 2 hours each time, combine the decoction, filter, and concentrate the filtrate under reduced pressure to a relative density of 1.27-1.30 (80°C), let it cool, add ethanol to make the containing The amount of ethanol is 65%, stand overnight, filter, the filtrate recovers ethanol under reduced pressure and concentrates to a relative density of 1.30 (80°C), add 3 times the amount of water, stir well, refrigerate for 48 hours, filter, and concentrate the filtrate under reduced pressure When the relative density is about 1.15 (80°C), the medicinal solution will be used for later use; decoct the wind orchid with water twice, 1 hour each time, combine the decoction, filter, and concentrate the filtrate to a relative density of 1.25-1.30 (80°C), put Cool, add ethanol to make the ethanol content 65%, let it stand overnight, filter, concentrate the filtrate under reduced pressure to a rela...

Embodiment 2

[0024]

[0025] Preparation method: Boil holly holly and mountain silver flower with water twice, 2 hours each time, combine the decoction, filter, and concentrate the filtrate under reduced pressure to a relative density of 1.27-1.30 (80°C), let it cool, add ethanol to make the containing The amount of ethanol is 65%, stand overnight, filter, the filtrate recovers ethanol under reduced pressure and concentrates to a relative density of 1.30 (80°C), add 3 times the amount of water, stir well, refrigerate for 48 hours, filter, and concentrate the filtrate under reduced pressure When the relative density is about 1.15 (80°C), the medicinal solution will be used for later use; decoct the wind orchid with water twice, 1 hour each time, combine the decoction, filter, and concentrate the filtrate to a relative density of 1.25-1.30 (80°C), put Cool, add ethanol to make the ethanol content 65%, let it stand overnight, filter, concentrate the filtrate under reduced pressure to a rela...

Embodiment 3

[0027]

[0028] Preparation method: Boil holly holly and mountain silver flower with water twice, 2 hours each time, combine the decoction, filter, and concentrate the filtrate under reduced pressure to a relative density of 1.27-1.30 (80°C), let it cool, add ethanol to make the containing The amount of ethanol is 65%, stand overnight, filter, the filtrate recovers ethanol under reduced pressure and concentrates to a relative density of 1.30 (80°C), add 3 times the amount of water, stir well, refrigerate for 48 hours, filter, and concentrate the filtrate under reduced pressure When the relative density is about 1.15 (80°C), the medicinal solution will be used for later use; decoct the wind orchid with water twice, 1 hour each time, combine the decoction, filter, and concentrate the filtrate to a relative density of 1.25-1.30 (80°C), put Cool, add ethanol to make the ethanol content 65%, let it stand overnight, filter, concentrate the filtrate under reduced pressure to a rela...

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PUM

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Abstract

The invention discloses a method for improving the safety of compound Maodongqing injection. According to the method, the pharmaceutical composition for injection is mainly prepared from extracts of holly holly, mountain silver flower, wind orchid and butyl p-hydroxybenzoate. The method of the present invention adopts the co-solvent with better safety and more obvious solubilizing effect to replace the co-solvent private plate 80 which has potential safety hazards and affects product quality in the compound Maodongqing injection, and the safety of butyl p-hydroxybenzoate is higher than that of the private plate. 80% and lower dosage, reducing the probability and risk of adverse drug reactions and improving the safety of clinical medication.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to a method for improving the safety of compound Maodongqing injection. Background technique [0002] The standard of compound Maodongqing injection is recorded in the drug standard issued by the Ministry of Health (Chinese medicine prescription preparation). The raw materials are Maodongqing, Shanyinhua and Fenglan, which belong to traditional Chinese medicine injection. It has the effects of promoting blood circulation and promoting menstrual flow, dispelling blood stasis and relieving pain. It is clinically used to treat dysmenorrhea, amenorrhea, injury from tumbling, rheumatic arthralgia, etc. [0003] Compound Maodongqing Injection has been widely used clinically in my country for many years, and its clinical efficacy has been well received by both doctors and patients. However, in recent years, reports of adverse reactions in the clinical application of traditio...

Claims

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Application Information

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IPC IPC(8): A61K36/898A61K47/14A61K9/19A61K9/08A61P15/00A61P29/00
CPCA61K36/185A61K9/0019A61K9/08A61K9/19A61K36/355A61K36/898A61K47/14A61K2236/331A61K2236/39A61K2236/51A61K2236/53A61K2300/00
Inventor 张蛟
Owner CHENGDU SHENGSHI GUANGHUA BIOTECH CO LTD
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