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Calanthe alpina extracts as well as preparation method and application thereof

A technology of fringed shrimp chili and extract, applied in the field of natural medicinal chemistry, can solve problems such as rare reports of pharmacological activity, and achieve the effects of strong activity, many side reactions, and improving glucose tolerance

Inactive Publication Date: 2018-03-20
XI AN JIAOTONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, domestic and foreign studies on the whole genus of the genus Shrimpia mainly focus on ornamental value, cultivation techniques, and breeding methods, while studies on its pharmacological activity are rarely reported.

Method used

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  • Calanthe alpina extracts as well as preparation method and application thereof
  • Calanthe alpina extracts as well as preparation method and application thereof
  • Calanthe alpina extracts as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] The preparation method of the total extract of the fringed shrimp spine orchid comprises the following steps:

[0035] Weigh about 200g of the dried rhizome of Shrimp Ridge orchid, add methanol according to the ratio of solid to liquid 1g:1mL, extract by cold soaking for 72h, reflux at 50°C for 3h, repeat 4 times, after combining the extracts, recover the solvent under reduced pressure, and dry at room temperature To a constant weight, 73.5 g of the total methanol extract of the tassel orchid orchid was obtained, and the extraction rate was 36.8%.

[0036] (2) After adding water to disperse the total extract of Tassel Shrimp Ridge Orchid, extract 5 times with petroleum ether to obtain petroleum ether extract and water phase, concentrate the petroleum ether extract under reduced pressure, dry at room temperature to constant weight, and obtain tassel 4.0 g of the petroleum ether extract of the shrimp spine orchid, and the yield is 2.0%.

Embodiment 2

[0038] The preparation method of the total extract of the fringed shrimp spine orchid comprises the following steps:

[0039] Weigh about 200g of the dried rhizome of Shrimp Orchid, add methanol according to the ratio of solid to liquid 1g:3mL, extract by cold soaking for 36 hours, and extract by reflux at 60°C for 2 hours, repeat 4 times, after combining the extracts, recover the solvent under reduced pressure, and dry at room temperature To a constant weight, 74.0 g of the total methanol extract of the tassel prawn orchid was obtained, and the extraction rate was 37.0%.

[0040] (2) Add water to disperse the total extract of Tassel Shrimp Ridge Orchid, extract 5 times with petroleum ether to obtain petroleum ether extract and water phase, concentrate the petroleum ether extract under reduced pressure, dry at room temperature to constant weight, and obtain tassel 5.0 g of the petroleum ether extract of the shrimp spine orchid, the yield is 2.5%.

Embodiment 3

[0042] The preparation method of the total extract of the fringed shrimp spine orchid comprises the following steps:

[0043] Weigh about 200g of the dried rhizome of the tassel prawn orchid, add methanol at a ratio of 1g:5mL, cold soak for 24 hours, and reflux for 1 hour at 70°C. Repeat 4 times. After combining the extracts, recover the solvent under reduced pressure and dry at room temperature To a constant weight, 72.5 g of the total methanol extract of the tassel orchid was obtained, and the extraction rate was 36.3%.

[0044](2) Add water to disperse the total extract of Tassel Shrimp Ridge Orchid, extract 4 times with petroleum ether to obtain petroleum ether extract and water phase, concentrate the petroleum ether extract under reduced pressure, dry at room temperature to constant weight, and obtain tassel Shrimp spines petroleum ether extract 4.6g, the yield is 2.3%.

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Abstract

The invention relates to calanthe alpina extracts as well as a preparation method and application thereof. The preparation method comprises the following steps: firstly, taking dry rhizomes of calanthe alpina, carrying out cold-dipping extraction on the dry rhizomes of the calanthe alpina for 24-72h by using methyl alcohol, and then carrying out reflux extraction to obtain extract; repeating the processes of the cold-dipping extraction and the reflux extraction for a plurality of times, merging the extract and then concentrating under reduced pressure so as to obtain a calanthe alpina extractA; replacing the methyl alcohol with an ethanol solution with mass concentration of 30-95% or water for carrying out cold-dipping extraction, carrying out reflux extraction and concentrating under reduced pressure so as to obtain a calanthe alpina extract B; adding water into the calanthe alpina extract A or the calanthe alpina extract B, and dispersing to obtain dispersion liquid; extracting thedispersion liquid with petroleum ether for a plurality of times, merging the petroleum ether extract, and concentrating under reduced pressure so as to obtain a calanthe alpina extract C. The calanthealpina extracts A and C prepared by the method have high activity, and can play a better role in prevention and cure processes of metabolic syndrome.

Description

technical field [0001] The invention belongs to the field of natural medicinal chemistry, and in particular relates to an extract of tamarind orchid and its preparation method and application. Background technique [0002] With the global industrialization, urbanization and modernization of life, people's lifestyles have undergone great changes. The intake of high-sugar and high-fat foods in the diet has increased, and the amount of exercise has decreased, resulting in "lifestyle-related diseases" such as high blood pressure and high blood pressure. The incidence of diseases such as blood lipids and diabetes is increasing day by day, and hyperlipidemia and lipid metabolism disorders are the main risk factors for atherosclerosis (AS), and sometimes lead to the occurrence of hypertension, diabetes, coronary heart disease and other diseases. Seriously endanger human health. The existing clinical chemical drugs for these diseases all have disadvantages such as high toxicity and...

Claims

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Application Information

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IPC IPC(8): A61K36/898A61P3/00A61P3/10A61P3/06
CPCA61K36/898A61K2236/33A61K2236/39A61K2236/51
Inventor 张海龙彭亚杰高阳张昌龙张晓庆
Owner XI AN JIAOTONG UNIV
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