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A kind of preparation method of Lianzhi anti-inflammatory tablet

A technology of anti-inflammatory tablets and Andrographis paniculata, which is applied in the directions of non-active ingredients medical preparations, medical preparations containing active ingredients, pharmaceutical formulas, etc. Ideal, affect drug efficacy and other issues, to achieve the effect of improving drug efficacy, speeding up dissolution rate, and improving absorption effect

Active Publication Date: 2020-02-11
NANHAI PHARMA CHONGQING
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] In the prior art, Lianzhi anti-inflammatory tablets are prepared with cornstarch as an auxiliary material, and the process is rough. The actual clinical application effect of Lianzhi anti-inflammatory tablets prepared in this way is not ideal. slow, which delays the action of the drug
[0004] In addition, the existing Lianzhi anti-inflammatory tablets all directly use Andrographis paniculata dry extract instead of the original Chinese herbal medicine of Andrographis paniculata. The quality of this dry extract, especially the purity of total andrographolide, cannot be guaranteed, which also affects drug efficacy

Method used

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  • A kind of preparation method of Lianzhi anti-inflammatory tablet
  • A kind of preparation method of Lianzhi anti-inflammatory tablet

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] Embodiment 1: Prepare Andrographis paniculata dry extract.

[0023] 1. Pulverize the leaves of Andrographis paniculata, pass through a 4-mesh sieve to obtain the Andrographis paniculata powder, take 5kg of Andrographis paniculata powder for subsequent use.

[0024] ② Put the Andrographis paniculata powder into a baking oven and heat it to 67°C.

[0025] ③Use 20 liters of 90% ethanol solution at 65°C to extract the heated Andrographis paniculata powder with 35kHz ultrasound for 60 minutes, then filter the solution; then use 40 liters of 90% ethanol solution to filter 35kHz ultrasonic extraction for 90 minutes, then filter the liquid and combine the extracts.

[0026] ④ Add 0.75kg of activated carbon to the filtrate, reflux at 72°C for 30 minutes for decolorization, and suction filter while it is hot, then add 0.5kg of activated carbon to the filtrate, reflux for 30 minutes at 72°C for decolorization, and suction and filter while it is hot .

[0027] ⑤Recover the ethan...

Embodiment 2

[0029] Example 2. Preparation of Andrographis paniculata dry extract.

[0030] 1. Pulverize the Andrographis paniculata leaves, pass through a 4-mesh sieve to obtain the Andrographis paniculata coarse powder, take 10kg of Andrographis paniculata coarse powder for subsequent use.

[0031] ② Put the Andrographis paniculata powder into a baking oven and heat it to 72°C.

[0032] ③Use 40 liters of 90% ethanol solution to extract the heated Andrographis paniculata powder with 37kHz ultrasound for 60 minutes at a temperature of 66°C, then filter the solution; then use 80 liters of 90% ethanol solution to filter 37kHz ultrasonic extraction for 90 minutes, then filter the liquid and combine the extracts.

[0033] ④ Add 1.5kg of activated carbon to the filtrate, reflux at 72°C for 30 minutes to decolorize, and suction filter while it is hot, then add 1.0kg of activated carbon to the filtrate, reflux at 72°C for 30 minutes to decolorize, and take the solution while hot .

[0034] ⑤R...

Embodiment 3

[0036] Example 3. Preparation of Andrographis paniculata dry extract.

[0037] 1. Pulverize the leaves of Andrographis paniculata, pass through a 4-mesh sieve to obtain the Andrographis paniculata powder, take 20kg of Andrographis paniculata powder for subsequent use.

[0038] ② Put the Andrographis paniculata powder into a baking oven and heat it to 77°C.

[0039] ③Use 80 liters of 90% ethanol solution at 67°C to extract the heated Andrographis paniculata powder with 40kHz ultrasound for 60 minutes, then filter the solution; then use 160 liters of 90% ethanol solution to filter 40kHz ultrasonic extraction for 90 minutes, then filter the liquid and combine the extracts.

[0040] ④ Add 3.0kg of activated carbon to the filtrate, reflux at 72°C for 30 minutes for decolorization, and suction filter while it is hot, then add 2.0kg of activated carbon to the filtrate, reflux for 30 minutes at 72°C for decolorization, and take out the solution while hot .

[0041] ⑤Recover the et...

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Abstract

The invention discloses a preparation method of a herba andrographis and radix helicteris anti-inflammatory tablet, and belongs to the technical field of traditional Chinese medicine preparations. Theherba andrographis and radix helicteris anti-inflammatory tablet is prepared from herba andrographis dry extract containing herba andrographis total lactone and radix helicteris dry extract. The herba andrographis and radix helicteris anti-inflammatory tablet has the beneficial effects that radix puerariae starch is mainly adopted as an auxiliary material, a bonding function can be achieved, andthe pharmaceutical effect of herba andrographis and radix helicteris medicine can be increased; by adding a dry powder mixture of herba andrographis and radix helicteris into pre-prepared starch pureein the end, the dissolution speed after a tablet is taken can be quickened; by adding corn starch in herba andrographis and radix helicteris starch puree in the end, the gelatinization degree of thecorn starch can be reduced, and the disintegration speed after the tablet is taken can be increased; as a whole, an absorption effect of the medicine in the body of a patient can be effectively increased; the adopted herba andrographis dry extract is ultrasonically extracted under an appropriate temperature by adopting ethanol in appropriate ratio and appropriate concentration after baking under the appropriate temperature and is then subjected to impurity removing and concentration, the extraction rate of andrographolide can be effectively increased, the purity can also be increased, and thequality and the production efficiency of a product are greatly increased.

Description

technical field [0001] The invention relates to a preparation method of a traditional Chinese medicine preparation, in particular to a preparation method of Lianzhi anti-inflammatory tablets. Background technique [0002] Lianzhi anti-inflammatory tablets are recorded in the standard WS of the Ministry of Health 3 -B-3977-98-8, made of Andrographis paniculata dry extract (calculated as andrographolide) 15g, mountain sesame dry extract 43g as raw materials, can clear away heat and detoxify, cool blood and reduce swelling, and is used for lung and stomach with heat , Fire toxins contained within cause cough and asthma, mumps, milk moths, sore throat and sore throat embolism. [0003] In the prior art, Lianzhi Anti-inflammatory Tablets are prepared with cornstarch as an auxiliary material, and the process is rough. The actual clinical application effect of Lianzhi Anti-inflammatory Tablets prepared in this way is not ideal. The speed is slow, so that the action time of the dr...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/20A61K36/19A61K47/36A61P31/00A61P11/04A61P31/14A61P11/14A61P11/06A61K36/185
CPCA61K9/2059A61K36/185A61K36/19A61K2236/333A61K2236/39A61K2236/51A61K2236/55A61K2300/00
Inventor 周兵罗庆林冉超黄敏唐金春
Owner NANHAI PHARMA CHONGQING
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