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Method for researching blood sugar reduction assisting function of oligopeptides of Apostichopus japonicus Liao

An oligopeptide and hypoglycemic technology, applied in the field of biotechnology, can solve problems such as few reports

Inactive Publication Date: 2018-05-25
大连平岛天然产物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Studies have shown that sea cucumber oligopeptides have many functions such as lowering blood pressure, anti-oxidation, improving immunity, and anti-aging, but there are few reports on the related aspects of sea cucumber oligopeptides in reducing blood sugar

Method used

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  • Method for researching blood sugar reduction assisting function of oligopeptides of Apostichopus japonicus Liao
  • Method for researching blood sugar reduction assisting function of oligopeptides of Apostichopus japonicus Liao
  • Method for researching blood sugar reduction assisting function of oligopeptides of Apostichopus japonicus Liao

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Embodiment Construction

[0029] In order to further illustrate the present invention, the technical solutions of the present invention are described in conjunction with specific examples.

[0030] In the examples of the present invention, the Kunming mice used, weighing 20±2 g, all male, were purchased from Dalian Medical University. Liao sea cucumber oligopeptide: provided by Dalian Haoxiang Bioenzyme Engineering Co., Ltd. Metformin hydrochloride: get metformin hydrochloride tablets (Beijing Jingfeng Pharmaceutical Co., Ltd.), pulverize, and cross a 60-mesh sieve. Alloxan (analytical grade), nitric oxide synthase (NOS), nitric oxide (NO), superoxide dismutase (SOD) and malondialdehyde (MAD) kits (Nanjing Jiancheng Bioengineering Institute).

[0031] In the present example, the research method of Liao sea cucumber oligopeptide assisted hypoglycemic function, the specific steps are as follows:

[0032] The specific steps are as follows: (1) Establishment of mouse diabetes model and hypoglycemic test:...

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Abstract

The invention relates to a method for the researching blood sugar reduction assisting function of oligopeptides of Apostichopus japonicus Liao and belongs to the technical field of biotechnology. Themethod comprises the following specific steps: establishing a mouse diabetes model and performing blood sugar reduction tests; detecting various indexes of diabetic mice; calculating organ coefficients; determining activity of nitric oxide synthase of serum; determining content of nitric oxide of the serum; determining activity of superoxide dismutase of the serum; determining content of malondialdehyde of the serum; performing statistical treatment: significance analysis is performed with SPSS22.0 software, and a result is indicated by x(average) plus / minus SD. The research method proves thatoligopeptides of the Apostichopus japonicus Liao not only have a certain treatment assisting function on blood sugar rising of the alloxan induced diabetic mice, but also can remarkably improve in-vivo oxidation resistance of the diabetic mice, effectively scavenge free radicals, improve activity of in-vivo antioxidant enzymes and prevent diabetic complications, and theoretical basis is providedfor development and utilization of blood sugar reduction assisting products by oligopeptides of the Apostichopus japonicus Liao.

Description

Technical field: [0001] The invention relates to a method for researching the hypoglycemic function of japonicus japonicus oligopeptide, which belongs to the technical field of biotechnology. Background technique: [0002] Diabetes is one of the diseases that seriously endanger human health. As the global aging trend intensifies, the incidence rate is increasing year by year. Therefore, a safe, reliable and convenient method to control blood sugar is particularly important for the prevention and treatment of diabetes. [0003] Sea cucumber is the collective name for all organisms of the Echinodermata phylum Holothuria. There are more than 1,100 existing species, and nearly 300 species of sea cucumber have been commercially exploited. There are more than 160 species of sea cucumbers in my country. Sea cucumber (Apostichopus japonicus) is distributed in the waters north of Lianyungang, Jiangsu, China, and is the best quality among more than 20 kinds of edible sea cucumbers in...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K35/616A61K49/00A61P3/10G01N33/48
CPCA61K35/616A61K49/0008G01N33/48
Inventor 黄祥贤
Owner 大连平岛天然产物科技有限公司