Experimental system and method suitable for macro-molecule crystallization process accurate regulation and control

An experimental system and macromolecular technology, applied in the field of experimental systems for precise regulation of macromolecular crystallization process, can solve problems such as unfavorable crystal form observation, and achieve the effect of improving crystallization efficiency and success rate

Active Publication Date: 2018-06-15
DALIAN UNIV OF TECH
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  • Abstract
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  • Claims
  • Application Information

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Problems solved by technology

However, the confined space is not conducive to the observation of crystal forms related to the crys...

Method used

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  • Experimental system and method suitable for macro-molecule crystallization process accurate regulation and control
  • Experimental system and method suitable for macro-molecule crystallization process accurate regulation and control
  • Experimental system and method suitable for macro-molecule crystallization process accurate regulation and control

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Embodiment Construction

[0036] The specific implementation manners of the present invention will be further described below in conjunction with the accompanying drawings and technical solutions.

[0037] With the case of lysozyme crystal culture, the application method of the invention is explained in detail.

[0038] Prepare the lysozyme crystal culture solution, put it into the sample injector 6 for standby, place the high-throughput macromolecular crystal culture platform 5 on the horizontal moving tank 2 of the platform, and complete the preparatory work before crystal culture;

[0039] Adjust the temperature and humidity measurement and control device 13 so that the temperature and humidity conditions in the enclosure 1 of the confined space reach the value set during the lysozyme crystallization process, and the temperature and humidity during the entire experiment process are controlled by the experimental condition control module V;

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Abstract

The invention belongs to the technical field of crystallization, and relates to an experimental system and a method suitable for macro-molecule crystallization process accurate regulation and control.The experimental system is an enclosed space under normal pressure, and is mainly composed of a platform arrangement horizontal moving tank and a runner special-purpose backwashing module, a liquid drop dropwise adding control module, an observation module, a user observation computer system, and an experimental condition control module. In applications, a system x and y axis platform high precision moving turn button and syringe needle accurate position control are capable of ensuring a molecular solution is added at right convex or concave positions, ensuring crystal crystallization micro environment and later crystal backwashing accurate operation; a high-power camera is adopted for real-time data measuring of target crystal form crystallization induction period, realizing real-time adjusting of crystal culture environment based on experimental conditions, increasing crystallization efficiency and success rate. The experimental system and the method are simple; the yield is relatively high; the experimental system and the method can be used for routine experiment repetition, and limit crystallization condition exploration.

Description

technical field [0001] The invention belongs to the technical field of crystallization, and relates to an experimental system and method suitable for precise regulation and control of macromolecular crystallization process. Background technique [0002] The demand for drugs based on macromolecular drugs is increasing, which promotes the development of crystallization of related macromolecular drugs. From the discovery of the pharmacodynamic effect of macromolecular drugs to the design of drug structures, stable production process design and preparation process development have become important research directions for the commercialization of new drugs. Among them, the crystallization process of macromolecular drugs is the focus of the production process design. Controlling the target crystal form of the drug, shortening the crystallization induction cycle, and preparing large quantities of crystals greatly affect the cost and production feasibility of the drug preparation pr...

Claims

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Application Information

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IPC IPC(8): C12M1/40C12M1/38C12M1/36C12N9/98C12N9/36
CPCC12M21/18C12M41/00C12M41/12C12M41/34C12N9/2462C12N9/98C12Y302/01017
Inventor 姜晓滨韩明光贺高红李祥村肖武吴雪梅
Owner DALIAN UNIV OF TECH
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