Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Poacynum hendersonii purified material with antiphlogistic activity and application thereof

A kind of active white hemp technology, which is applied in the direction of medical preparations containing active ingredients, anti-inflammatory agents, drug combinations, etc., can solve the problems of weak effect and difficult development of big-leaf white hemp, and achieve the improvement of anti-inflammatory activity Effect

Active Publication Date: 2018-07-20
新疆维吾尔自治区中药民族药研究所
View PDF1 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Big-leaf white hemp has biological activities such as liver protection, anti-anxiety, anti-depression, lowering blood pressure, anti-oxidation and antibacterial, but its effects are weaker than that of Apocynum acynum, which is one of the reasons why it is difficult to develop big-leaf white hemp

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Poacynum hendersonii purified material with antiphlogistic activity and application thereof
  • Poacynum hendersonii purified material with antiphlogistic activity and application thereof
  • Poacynum hendersonii purified material with antiphlogistic activity and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] Embodiment one: the preparation of purified product

[0032] The purified white hemp with anti-inflammatory activity provided by the present invention is prepared by the following preparation method:

[0033] (1) Add ethanol solution to reflux extraction for 1-2h / time in the white hemp sample, and combine the extracts;

[0034] (2) Concentrating the extract of step (1) to alcohol-free;

[0035](3) After the concentrated extract, add deionized water to adjust the concentration to 0.02-0.1g / ml liquid medicine, pass through the macroporous resin column, 1-3BV water to elute and remove impurities at a speed of 1-2BV / h, and then add 1-4BV 60%-90% ethanol is eluted at a rate of 1-2BV / h and the eluate is collected, concentrated and dried to obtain a purified product.

[0036] The composition of the purified white hemp prepared by the preparation method of the present invention contains the following substances: more than 10% of leucin, and at least agaricin, isorhamnetin-3-O...

Embodiment 2

[0037] Embodiment two: the preparation of purified product

[0038] Add 15 times the weight of 70% ethanol to the big-leaf white hemp sample and reflux extract twice, 1.5h / time, concentrate the extract to no alcohol, add deionized water to adjust the concentration to 0.05g / ml liquid, and pass the non-polar Macroporous resin column, eluted with 2BV water at a rate of 1.5BV / h to remove impurities, then added 2.5Bv 75% ethanol solution for elution and collected the eluate, concentrated and dried the collected eluate to obtain the purified product.

Embodiment 3

[0039] Embodiment three: the preparation of purified product

[0040] Add 10 times the weight of 80% ethanol to the big-leaf white hemp sample to reflux and extract once, 1h / time, the extract is concentrated to no alcohol by vacuum distillation, and the concentration is adjusted to 0.02g / ml liquid by adding deionized water. After passing through a HPD300 macroporous resin column, 1BV of water was eluted at a rate of 1BV / h to remove impurities, and then 1BV of 60% ethanol was added to elute at a rate of 1BV / h. The eluate was collected, concentrated, and dried to obtain a purified product.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention provides a poacynum hendersonii purified material with antiphlogistic activity. The material is prepared by a following preparation method with the steps of (1) adding 15 times of weightof 70-percent ethyl alcohol into a poacynum hendersonii sample for backflow extraction for two times according to 1.5h / time; merging extraction liquid; 2) concentrating the extraction liquid until noalcohol exists; (3) adding deionized water into the concentrated extraction liquid for dilution; passing the material through a macroporous resin column; performing fast water washing for impurity removal; then, adding 75-percent ethyl alcohol for elution; collecting the elution liquid; performing concentration and drying to obtain the purified materials. The poacynum hendersonii purified material enriches the ingredients with the antiphlogistic activity in the poacynum hendersonii, so that the antiphlogistic activity of the poacynum hendersonii purified material is improved, so that the poacynum hendersonii purified material can be applied to the preparation of relevant products for preventing and treating inflammatory diseases.

Description

technical field [0001] The invention relates to the technical field of medicine preparation, in particular, the invention relates to the technical field of preparation and application of white hemp. technical background [0002] Inflammation is the body's stress response to infection or injury and helps the body get back to normal as quickly as possible. Many infectious diseases and chronic non-communicable diseases such as cardiovascular diseases, malignant tumors, diabetes, and autoimmune diseases belong to the category of inflammatory diseases. These diseases have spread globally and have evolved into important public health problems that seriously endanger human health. , Screening anti-inflammatory active ingredients and components can provide a new direction for the prevention and treatment of related diseases. [0003] Big-leaf white hemp, Apocynaceae white hemp, another name: Apocynum white hemp, wild hemp, big-flowered apocynum, is an upright semi-shrub, mainly dis...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/24A61P29/00
CPCA61K36/24A61K2236/333A61K2236/39A61K2236/51A61K2236/55
Inventor 张娟卿德刚倪慧孙宇徐晓琴冯春艳徐建国
Owner 新疆维吾尔自治区中药民族药研究所
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com