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Application of baicalin in preparation of medicine for preventing rotavirus

A technology of rotavirus and baicalin, applied in the field of baicalin, to achieve far-reaching significance and value

Active Publication Date: 2018-08-10
GUANGDONG MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Baicalin (structural formula as follows) is a flavonoid derived from the root of Scutellaria baicalensis Georgi, a perennial herb of the genus Scutellaria, which is a traditional Chinese medicine. Studies have shown that baicalin has inhibitory effects on influenza virus, herpes simplex virus, coxsackie virus, respiratory syncytial virus, hepatitis C virus, etc., but whether baicalin has an effect on RV has not been reported

Method used

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  • Application of baicalin in preparation of medicine for preventing rotavirus
  • Application of baicalin in preparation of medicine for preventing rotavirus
  • Application of baicalin in preparation of medicine for preventing rotavirus

Examples

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Embodiment 1

[0019] The application of baicalin in this example in the preparation of anti-rotavirus drugs is the first time that the applicant has discovered that baicalin has an anti-rotavirus effect, fills the gap in anti-rotavirus drugs, and has far-reaching significance and value.

Embodiment 2

[0021] The application of baicalin in this embodiment in the preparation of anti-rotavirus drugs, wherein the molar concentration of baicalin in the anti-rotavirus drugs is 3.125 umol / L to 400 umol / L.

Embodiment 3

[0023] The application of baicalin in the present embodiment in the preparation of anti-rotavirus drugs, wherein, in the anti-rotavirus drugs, the molar concentration of baicalin that is toxic to cells is greater than 800 umol / L.

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Abstract

The invention relates to the technical filed of baicalin, and specifically relates to application of baicalin in preparation of a medicine for preventing rotavirus. The application is characterized inthat the inventor researches and finds out the effect of baicalin in preventing rotavirus for the first time, thus the gap in rotavirus preventive medicines is filled; the baicalin is of important significance and high value. The research shows that the molar concentration of baicalin in the medicine for preventing rotavirus is 3.125-400 [mu]mol / L.

Description

Technical field [0001] The invention relates to the technical field of baicalin, in particular to the application of baicalin in preparing anti-rotavirus drugs. Background technique [0002] Rotavirus (RV) is the main pathogen that causes acute diarrhea in infants and young children. About 600,000 infants and young children die each year due to RV infection. The epidemic mainly occurs in autumn and winter, and its occurrence is not affected by health conditions. The incidence rate in developed countries is similar to that in developing countries, but the mortality rate in developing countries is much higher than that in developed countries. RV is generally transmitted through the fecal-oral route, with an incubation period of 2 to 4 days. In the past, it was thought that RV mainly invaded the villi of small intestine cells. The main symptoms of patients were diarrhea, rapid onset, more than ten to dozens of times a day, and fever, and specific lgM and lgG antibodies appeared in ...

Claims

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Application Information

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IPC IPC(8): A61K31/7048A61P1/12A61P31/14
CPCA61K31/7048A61P1/12A61P31/14
Inventor 赵文昌宋丽军周若夏
Owner GUANGDONG MEDICAL UNIV
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