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Hypoglycemic usage of apios americana medikus flower ethyl alcohol extract

A technology of ethanol extraction and taro flower, applied in the field of medicine, can solve the problems of low cost, few reports on hypoglycemic function, etc., and achieve the effects of expanding application field, significant hypoglycemic effect, and good development prospect.

Inactive Publication Date: 2018-08-17
ZHEJIANG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although this is a disease with a wide range of influence and serious harm, it is difficult for us to start from a single aspect and find an effective, convenient and low-cost treatment because it is affected by many factors such as genetics, diet, and living habits. preventive measures treatment plan
How to prevent and treat diabetes and its related complications has attracted the attention of scholars all over the world, and natural plant active substances are especially favored, but there are few reports on the hypoglycemic function of the ethanol extract of taro flower

Method used

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  • Hypoglycemic usage of apios americana medikus flower ethyl alcohol extract

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0044] Embodiment 1, the hypoglycemic application of the ethanol extract of bean taro flower, as Figure 1-Figure 4 As shown, the HepG2 cells induced by high glucose were intervened with the ethanol extract of the taro flower, and the glucose uptake and consumption ability of the HepG2 cells was observed, indicating that the ethanol extract of the taro flower had a significant hypoglycemic effect.

[0045] Experiment 1, the effect of ethanol extract of taro flower on the proliferation activity of HepG2 cells;

[0046] HepG2 cells in the logarithmic phase were collected and seeded in a 96-well plate, with 5000 cells per well, placed at 37°C, 5% CO 2 Grouped after 24h incubation in the incubator.

[0047] Divided into the following 9 groups: blank control group, and 5, 10, 20, 40, 80, 160, 320 and 640ug / mL taro flower ethanol extract groups; the above 5, 10, 20, 40, 80, 160, 320 and 640ug / mL taro flower ethanol extract group were added with corresponding concentrations of etha...

Embodiment 2

[0063] Embodiment 2, as Figure 5-Figure 7 As shown, the ethanol extract of taro flower was used to intervene RINm5F cells induced by high glucose, and the insulin synthesis and secretion of RINm5F cells were observed, indicating that the ethanol extract of taro flower had a significant hypoglycemic effect.

[0064] Experiment 1. The effect of ethanol extract of taro flower on the proliferation activity of RINm5F cells;

[0065] Collect RINm5F cells in the logarithmic phase and inoculate them in 96-well plates with 5000 cells per well, and place them at 37°C, 5% CO 2 Grouped after 24h incubation in the incubator.

[0066] Divided into the following 9 groups: blank control group, and 5, 10, 20, 40, 80, 160, 320 and 640ug / mL taro flower ethanol extract groups; the above 5, 10, 20, 40, 80, 160, 320 and 640ug / mL taro flower ethanol extract group were added with corresponding concentrations of ethanol extract, and no ethanol extract was added to the blank control group.

[0067]...

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Abstract

The invention discloses a hypoglycemic usage of an apios americana medikus flower ethyl alcohol extract. A new resource is provided for developing natural hypoglycemic products in the fields of medical science, food science and the like. According to test evaluation on an HepG2 cell model and an RINm5F cell model built through high glucose induction, the apios americana medikus flower ethyl alcohol extract can obviously improve the capability of HepG2 cell on consuming and ingesting glucose, and promotes RINm5F cell to be synthesized and secrete insulin, and the effect is comprehensive and outstanding. Therefore, the apios americana medikus flower ethyl alcohol extract can be applied to preparation of hypoglycemic food or drugs so as to cure and prevent occurrence of diabetes and related chronic diseases thereof.

Description

technical field [0001] The invention relates to the field of medicine, in particular to the hypoglycemic use of the ethanol extract of bean taro flower. Background technique [0002] American bean taro (Apios americana Medikus) mainly grows in North America between Ontario, Canada and Florida, USA, and currently has a wide range of planting areas in Europe, America and Japan. This is a perennial leguminous plant of the genus Solanum, similar to a potato. The edible part is the underground tuber, which is a high-protein, high-calcium food, so it is used as a staple food by the Indians. American bean taro was introduced to China in 2009 and has been well cultivated. Studies have shown that its flowers, leaves and tubers are rich in free amino acids, soluble protein, flavonoids, isoflavones, saponins, vitamins and minerals. Among them, taro flower contains higher content of vitamins, total saponins and isoflavones, and has great potential for development. [0003] According...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/48A61P3/10A23L33/105A61K133/00
CPCA23V2002/00A61K36/48A61K2236/33A61K2236/39A61K2236/51A61K2236/53A61K2236/55A23L33/105A61P3/10A23V2200/328A23V2250/21A23V2250/082A23V2300/14
Inventor 郑晓冬俞露霜楚强李永璐刘阳阳李禧禧
Owner ZHEJIANG UNIV
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