Traditional Chinese medicine composition for treating intestinal metaplasia and preparation method thereof

A technology of composition and intestinal epithelium, which is applied in the direction of drug combination, pharmaceutical formula, medical preparations containing active ingredients, etc., can solve the problems of negative impact on patient health and economic burden, waste of resources of Chinese herbal medicines, toxic and side effects of anticancer drugs, etc. , to achieve the effect of promoting standardized treatment, taking conveniently, and reversing gastric precancerous lesions

Inactive Publication Date: 2018-09-25
NANJING UNIVERSITY OF TRADITIONAL CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, most of the existing prescriptions for the treatment of gastric cancer are various traditional Chinese medicines (such as CN107753864A, CN107890550A) that are piled up in pharmacological studies and have anticancer effects. Most of the anticancer drugs themselves have certain toxic and side effects. Drug abuse is not only a waste of traditional Chinese medicine resources, but also has a serious negative impact on the health and economic burden of patients

Method used

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  • Traditional Chinese medicine composition for treating intestinal metaplasia and preparation method thereof
  • Traditional Chinese medicine composition for treating intestinal metaplasia and preparation method thereof
  • Traditional Chinese medicine composition for treating intestinal metaplasia and preparation method thereof

Examples

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Effect test

Embodiment 1

[0038] Mix 50 parts of Hedyotis diffusa, 8 parts of Zedoary Curcuma, 25 parts of raw coix seed, and 25 parts of Shi Jianchuan, decoct 3 times with water 8 times the weight of the total medicinal materials, and filter the decoction after 30-60 minutes each time , the decoctions are combined and concentrated at 60°C under normal pressure to obtain the extract, which is mixed with the carrier lactose or corn starch, granulated, dried, added with the lubricant magnesium stearate, mixed evenly, and then pressed into tablets to form tablets.

Embodiment 2

[0040]Mix 80 parts of Hedyotis diffusa, 15 parts of Zedoary Curcuma, 30 parts of Raw Coix Seed, and 35 parts of Shi Jianchuan, decoct 3 times with water 10 times the weight of the total medicinal materials, and filter the decoction after 30-60 minutes each time , the decoctions are combined and then concentrated under reduced pressure at 60°C to obtain the extract, which is mixed evenly with the carrier lactose or cornstarch, granulated, and then packed into capsules to make capsules.

Embodiment 3

[0042] Mix 30 parts of Hedyotis diffusa, 10 parts of Curcuma, 30 parts of Raw Coix Seed, and 30 parts of Shi Jianchuan, decoct 3 times with water 8 times the weight of the total medicinal materials, and filter the decoction after 30-60 minutes each time , the decoctions are combined and then concentrated under reduced pressure at 60°C to obtain the extract, which is evenly mixed with the carrier lactose or cornstarch, granulated, and dried to make granules.

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Abstract

The invention discloses a traditional Chinese medicine composition for treating intestinal metaplasia and a preparation method thereof. The traditional Chinese medicine composition comprises active ingredients: 30-80 parts by weight of hedyotis diffusa, 8-15 parts by weight of rhizoma curcumae, 20-30 parts by weight of raw coix seed and 25-35 parts by weight of salvia chinensis. The traditional Chinese medicine composition for treating intestinal metaplasia as gastric precancerous lesion and adopting the four drugs for intestinal metaplasia has a scientific ratio, and the components can coordinate and promote each other and produce a synergistic effect. The traditional Chinese medicine believes that the traditional Chinese medicine pathogenesis of intestinal metaplasia as gastric precancerous lesion can be summarized as spleen and stomach weakness, and damp heat and blood stasis combination. The traditional Chinese medicine treatment utilizes the principle of strengthening body resistance and eliminating evil. The traditional Chinese medicine composition has effects of clearing away heat, removing toxins and resolving dampness, and promoting blood circulation, removing blood stasisand eliminating stagnation, simplifies the formula, accurately utilizes drugs, has a precise formula, can reverse the precancerous lesions of the gastric cancer, has a definite clinical effect, is easy to take, has good patient tolerance and prevents untoward effects in long term use. The traditional Chinese medicine preparation can promote standardized treatment with traditional Chinese medicines.

Description

technical field [0001] The invention relates to a traditional Chinese medicine composition for treating intestinal metaplasia of gastric precancerous lesions and a preparation method thereof, belonging to the technical field of traditional Chinese medicines. Background technique [0002] Gastric cancer is a common digestive tract tumor. According to the 2012 global cancer epidemiological statistical study, the incidence of gastric cancer ranks third in the world, and its mortality rate ranks fourth. In China, gastric cancer is one of the most common malignant tumors of the digestive tract, and its incidence rate remains high all year round. According to the survey released at the Eighth National Gastric Cancer Academic Conference held in Beijing in 2013, in the past five years, the number of newly diagnosed gastric cancer cases in the country can reach as high as 400,000 each year, accounting for about 42% of the total incidence of gastric cancer in the world. In the same y...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/9066A61P35/00A61P1/00
CPCA61K36/537A61K36/748A61K36/8994A61K36/9066A61K2236/331A61K2236/39A61P1/00A61P35/00A61K2300/00
Inventor 徐力鹿竞文李秋逸
Owner NANJING UNIVERSITY OF TRADITIONAL CHINESE MEDICINE
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