Pharmaceutical composition for treating chronic constipation
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A technology for chronic constipation and composition, applied in the field of medicine, can solve the problems of easy drug dependence, long-term medication use, etc.
Inactive Publication Date: 2018-10-09
蒋桂荣
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Although commonly used laxatives have good laxative effects, the biggest problem is that they are prone to drug dependence. Generally, if you take them for more than ten days, you will not be able to defecate on your own without taking laxatives. However, the formation is very stubborn, and some need to take medicine for many years, or even take medicine for life.
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experiment example 1
[0015] Experimental example 1 Characterization of the medicine of the present invention
[0016]
[0017] 1 H NMR (400MHz, d 6 -DMSO):1.28(9H,s),1.32-1.56(2H,m),1.57-1.65(2H,m),1.66-1.77(5H,m),1.80-2.08(5H,m),2.08-2.16 (2H,m),2.14(3H,s),2.78-2.87(1H,m),3.14(4H,t,J=5.4Hz),4.46(1H,septet,J=4.2Hz),4.77-4.85 (1H,m),5.54(1H,t,J=4.2Hz),6.34(1H,s),7.05(1H,broad peak d,J=8.6Hz),7.10(1H,dd,J=2.2,8.4 Hz),7.15(1H,dd,J=2.1,10.0Hz),7.22-7.35(4H,m),7.36-7.40(1H,m),7.52-7.56(1H,m),7.59-7.64(2H, m), 8.15(1H,s).
experiment example 2
[0018] Experimental Example 2 Effect of Drug Treatment of the Present Invention on Chronic Constipation
[0019] Chronic constipation model establishment
[0020] 50 healthy SD rats were randomly divided into a blank group, a model group, a low-dose group of the drug of the present invention, a medium-dose group of the drug of the present invention, and a high-dose group of the drug of the present invention, with 10 rats in each group. The basal diet was given adaptive feeding for 1 week. Except for the blank group, the other groups were fasted for 24 hours in the morning of the first day before the experiment, and the models were established on the next day. Give compound diphenoxylate suspension 2mg / 100g orally in the morning every day, and give Shanxi white vinegar 1mL / 100g orally in the afternoon, with an interval of 6h between two gavages, and continuous gavage for 15 days, and observe the mental state and activity of rats in each group every day , diet, fur, feces, body...
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Abstract
Chronic constipation is a common disease of the digestive system, and the prevalence rate of chronic constipation around the world is 0.7 to 79%. The invention discloses a pharmaceutical composition for treating chronic constipation. The pharmaceutical composition comprises 4-12 mg of an active medicinal ingredient and other pharmaceutically acceptable carriers, diluents and excipients. The pharmaceutical composition of the invention can increase the number of ILL, repair the function of ILL and achieve the purposes of restoring colonic functions, improving the propulsion rate of small intestine and alleviating the symptoms of constipation.
Description
technical field [0001] The invention relates to the field of medicine, in particular, the invention relates to a pharmaceutical composition for treating chronic constipation. Background technique [0002] It is generally believed that the incidence of constipation in the population is 3% to 4%, and the elderly population is as high as 30%. Although commonly used laxatives have good laxative effects, the biggest problem is that they are prone to drug dependence. Generally, if you take them for more than ten days, you will not be able to defecate on your own without taking laxatives. However, the formation is very stubborn, and some need to take medicine for many years, or even take medicine for life. For this reason, the present invention aims at developing a kind of medicine with high safety and little side effect to treat chronic constipation. Contents of the invention [0003] The object of the present invention is to provide a pharmaceutical composition for treating c...
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