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Application of blood glucose reduction of Apios americana leaf polysaccharides

A technology for lowering blood sugar and bean taro, which is applied in the field of medicine, can solve the problems of few reports and low cost, and achieve the effects of expanding application fields, significant blood sugar lowering effect, and good development prospects

Inactive Publication Date: 2018-10-23
ZHEJIANG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although this is a disease with a wide range of influence and serious harm, it is difficult for us to start from a single aspect and find an effective, convenient and low-cost treatment because it is affected by many factors such as genetics, diet, and living habits. preventive measures treatment plan
How to prevent and treat diabetes and its related complications has attracted the attention of scholars all over the world, and natural plant active substances are especially favored, but there are few reports on the hypoglycemic function of bean taro leaf polysaccharides

Method used

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  • Application of blood glucose reduction of Apios americana leaf polysaccharides
  • Application of blood glucose reduction of Apios americana leaf polysaccharides
  • Application of blood glucose reduction of Apios americana leaf polysaccharides

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0047] Embodiment 1, the hypoglycemic purposes of soybean taro leaf polysaccharide, such as Figure 1-Figure 4 As shown in the figure, the HepG2 cells induced by high glucose were intervened with taro leaf polysaccharide, and the glucose uptake and consumption capacity of HepG2 cells was observed, indicating that the taro leaf polysaccharide has a significant hypoglycemic effect.

[0048] Experiment 1. The effect of soybean taro leaf polysaccharide on the proliferation activity of HepG2 cells;

[0049] HepG2 cells in log phase were collected and seeded in a 96-well plate, 5000 cells per well, at 37°C, 5% CO. 2 Grouped after 24h incubation in the incubator.

[0050] Divided into the following 9 groups: blank control group, and 5, 10, 20, 40, 80, 160, 320 and 640ug / mL soybean taro polysaccharide groups; the above 5, 10, 20, 40, 80, 160, 320 and 640ug The corresponding concentration of ethanol extract was added to the taro polysaccharide group / mL, while the blank control group ...

Embodiment 2

[0066] Embodiment 2, as Figure 5-Figure 7 As shown, the RINm5F cells induced by high glucose were intervened with taro leaf polysaccharide, and the insulin synthesis and secretion of RINm5F cells were observed, indicating that the taro leaf polysaccharide has a significant hypoglycemic effect.

[0067] Experiment 1. The effect of soybean taro leaf polysaccharide on the proliferation activity of RINm5F cells;

[0068] The RINm5F cells in log phase were collected and seeded into 96-well plates, with 5000 cells per well, and were incubated in a 37°C, 5% CO2 incubator for 24 hours and then grouped.

[0069] Divided into the following 9 groups: blank control group, and 5, 10, 20, 40, 80, 160, 320 and 640ug / mL soybean taro polysaccharide groups; the above 5, 10, 20, 40, 80, 160, 320 and 640ug The corresponding concentration of ethanol extract was added to the soybean taro polysaccharide group respectively, and the ethanol extract was not added to the blank control group.

[0070]...

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Abstract

The invention discloses an application of blood glucose reduction of Apios americana leaf polysaccharides and can supply a new resource for developing natural blood glucose reduction products in the fields of medicine, food science and the like. In the invention, experimental evaluation by constructing a HepG2 cell model and a RINm5F cell model through high glucose induction can prove that the Apios americana leaf polysaccharides can significantly improve capability of consuming glucose intake by HepG2 cells and promote RINm5F cells to synthesize and secrete insulin, so that the product has comprehensive and significant effects. The Apios americana leaf polysaccharides can be used for preparing blood glucose reduction foods or medicines in order to treat and prevent diabetes, as well as related chronic diseases.

Description

technical field [0001] The invention relates to the field of medicine, in particular to a hypoglycemic application of soybean taro polysaccharide. Background technique [0002] American bean taro (Apios americana Medikus) is mainly grown in North America between Ontario, Canada and Florida in the United States, and currently has a wide range of planting areas in Europe, America and Japan. This is a perennial leguminous plant of the genus Tulsa, similar to potatoes. The edible part is the underground tuber, which is a high-protein and high-calcium food, so it is used as a staple food by the Indians. American bean taro was introduced into China in 2009 and has been well cultivated. Studies have shown that its flowers, leaves and tubers are rich in free amino acids, soluble proteins, flavonoids, isoflavones, saponins, vitamins and minerals. Among them, taro flower contains high content of vitamins, total saponins and isoflavones, and has great potential for development. [...

Claims

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Application Information

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IPC IPC(8): A61K31/715A23L33/125A61P3/10
CPCA23V2002/00A61K31/715A61K36/48A23L33/125A61P3/10A23V2200/328
Inventor 郑晓冬俞露霜楚强刘阳阳李永璐李禧禧
Owner ZHEJIANG UNIV
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