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Extracting method of carpesium abrotanoides lactone

A technology of Tianmingjing lactone ketone and extraction method, which is applied in the field of Tianmingjing lactone ketone extraction, can solve the problems of low purification purity, complex extraction process, large solvent, etc., and achieve improved elution efficiency and extraction process Simplicity and the effect of reducing the amount of solvent used

Inactive Publication Date: 2018-10-23
湖州展舒生物科技有限公司
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AI Technical Summary

Problems solved by technology

[0003] In order to solve the problem that the traditional silica gel column chromatography is used in the extraction process of Tianmingjing lactone ketone, a large amount of solvent is consumed, the extraction process is complicated, and the purification purity is not high, the present invention provides a simple and easy-to-use Tianmingjing lactone ketone extraction method; including the following:

Method used

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Embodiment

[0021] This embodiment provides a method for extracting Tianmingjing lactone ketone, comprising the following steps:

[0022] (1) Take 3 kg of Tianmingjing whole herb and physically pulverize it;

[0023] (2) reflux for 2 hours with 5 liters of 95% ethanol solution, and extract twice;

[0024] (3) Get the extract and concentrate to dryness;

[0025] (4) The concentrated solution is eluted with 1 kg of MCI-filled column, 2 liters of 20% methanol solution, and then 5 liters of 50% methanol solution;

[0026] (5) Concentrate and crystallize the solution eluted with 50% ethanol solution with ethyl acetate; obtain 18 grams of Tianmingjing lactone ketone product. The purity of Tianmingjing lactone ketone obtained by this method reaches 98.27%; the molecular formula of the product: C15H20O3; molecular weight: 248.3175; appearance: white crystalline powder; solubility: soluble in methanol, ethanol, ethyl acetate, slightly soluble in water , almost insoluble in petroleum ether; stab...

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Abstract

The invention provides an extracting method of carpesium abrotanoides lactone. A preparation method of the carpesium abrotanoides lactone comprises the following steps of (1) selecting whole grass ofcarpesium abrotanoides, and physically crushing; (2) refluxing by an ethyl alcohol solution, and extracting; (3) concentrating the extracting solution; (4) eluting the concentrating solution by a MCIsmall-pore adsorption column; (5) concentrating and crystallizing the eluting solution, so as to obtain the carpesium abrotanoides lactone extract. The purity of the prepared carpesium abrotanoides lactone can reach 98.27%. The extracting method has the advantages that the extracting technology is simple, the MCI small-pore adsorption column is used for replacing the traditional silica gel columnin the prior art to elute, the eluting efficiency is greatly improved, the usage amount of solvent is reduced, and the cost is reduced.

Description

technical field [0001] The present invention relates to plant extracts, in particular to a method for extracting Tianmingjing lactone. Background technique [0002] Tianmingjing lactone ketone, English name: carabrone; mainly extracted from Tianmingjing whole herb, the existing extraction method uses traditional silica gel column chromatography, which consumes a large amount of organic solvents, and the efficiency is extremely low, and it can be obtained The purity of Tianming Jinglide ketone is not high. The Tianmingjing lactone ketone extraction method provided by the invention is simple and convenient, consumes less solvent and has high product purity. Contents of the invention [0003] In order to solve the problems that the traditional silica gel column chromatography is used in the extraction process of Tianmingjing lactone ketone, a large amount of solvent is consumed, the extraction process is complicated, and the purification purity is not high, the present inven...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07D307/93
CPCC07D307/93
Inventor 吴建华
Owner 湖州展舒生物科技有限公司
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