Use of bucchiol in the preparation of endothelium-independent vasodilators

A kind of bucchini alcohol, non-dependent technology, applied in the field of application of buccal alcohol in the preparation of endothelium-independent vasodilators

Inactive Publication Date: 2021-09-10
CHENGDU UNIV OF TRADITIONAL CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

There is no report on the relationship between buccalol and endothelium-independent vasodilation

Method used

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  • Use of bucchiol in the preparation of endothelium-independent vasodilators
  • Use of bucchiol in the preparation of endothelium-independent vasodilators
  • Use of bucchiol in the preparation of endothelium-independent vasodilators

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] Example 1: Bukitschyl Alcohol Concentration-Dependent Diastolic Effects of Potassium Chloride Precontracted Endothelialized Vascular Rings

[0019] 1 Materials and Instruments

[0020] 1.1 Drugs and preparation

[0021] Patchouli medicinal material was collected from the patchouli planting base in Yangchun County, Guangdong Province in November 2012. It was identified as Pogostemon cablin (Blanco ) Benth.) whole plant.

[0022] Take 40Kg of the dried above-ground part of Patchouli medicinal material, use a large-scale improved steam distillation device to extract, dry and remove water through anhydrous sodium sulfate, and finally obtain 215g of Patchouli volatile oil. Use silica gel column chromatography (100-200 mesh, 5Kg, 20×150cm) to chromatographically separate the volatile oil, use petroleum ether-acetone (100:0-0:100) as the mobile phase for gradient elution, and the eluent passes through thin layer For chromatographic detection, fractions with similar composit...

Embodiment 2

[0041] EXAMPLE 2: Buocchiol concentration-dependent relaxation of phenylephrine-precontracted endothelialized vascular rings

[0042] 1 Materials and Instruments

[0043] 1.1 Drugs and preparation

[0044] Patchouli medicinal material was collected from the patchouli planting base in Yangchun County, Guangdong Province in November 2012. It was identified as Pogostemon cablin (Blanco ) Benth.) whole plant.

[0045]Take 40Kg of the dried above-ground part of Patchouli medicinal material, use a large-scale improved steam distillation device to extract, dry and remove water through anhydrous sodium sulfate, and finally obtain 215g of Patchouli volatile oil. Use silica gel column chromatography (100-200 mesh, 5Kg, 20×150cm) to chromatographically separate the volatile oil, use petroleum ether-acetone (100:0-0:100) as the mobile phase for gradient elution, and the eluent passes through thin layer For chromatographic detection, fractions with similar composition were combined, and...

experiment example 1

[0066] Experimental Example 1 Pocket Alcohol Treatment of Hypertension

[0067] 1 Materials and Instruments

[0068] 1.1 Drugs and preparation

[0069] Patchouli medicinal material was collected from the patchouli planting base in Yangchun County, Guangdong Province in November 2012. It was identified as Pogostemon cablin (Blanco ) Benth.) whole plant.

[0070] Take 40Kg of the dried above-ground part of Patchouli medicinal material, use a large-scale improved steam distillation device to extract, dry and remove water through anhydrous sodium sulfate, and finally obtain 215g of Patchouli volatile oil. Use silica gel column chromatography (100-200 mesh, 5Kg, 20×150cm) to chromatographically separate the volatile oil, use petroleum ether-acetone (100:0-0:100) as the mobile phase for gradient elution, and the eluent passes through thin layer For chromatographic detection, fractions with similar composition were combined, and the solvent was recovered to obtain 31 eluted fracti...

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Abstract

The invention discloses the application of buccal alcohol in the preparation of an endothelium-independent vasodilator. The invention also discloses a medicament for treating cardiovascular and cerebrovascular diseases caused by endothelial injury, which is a preparation prepared by using bocicol as an active ingredient and adding pharmaceutically acceptable auxiliary materials or auxiliary ingredients. The pottyrae alcohol of the present invention has a vasodilation effect independent of the endothelium, and has great clinical significance for the treatment of cardiovascular and cerebrovascular diseases.

Description

technical field [0001] The invention relates to a new application of buccal alcohol, in particular to an application in the preparation of an endothelium-independent vasodilator, which belongs to the field of medicines. Background technique [0002] Vasodilators are mainly used in the treatment of hypertension, congestive heart failure, myocardial ischemia, cerebral ischemia and peripheral vasospasm diseases. Vasodilators can be divided into two categories according to the vasodilation pathway: endothelium-dependent vasodilators, which refer to the synthesis and secretion of NO and PGI that rely on functional and structurally intact vascular endothelial cells 2 , EDHF and other vasodilation factors increase and / or ET-1 and other vasoconstriction factors caused by vasodilation drugs; release of NO, K + channel activation, and / or Ca 2 + Drugs that cause vasodilation, such as channel blockers. [0003] Studies have confirmed that the occurrence and development of cardiov...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/045A61P9/08A61P9/10A61P9/12A61P9/04A61P25/00
CPCA61K31/045A61P9/04A61P9/08A61P9/10A61P9/12A61P25/00
Inventor 彭成胡冠英谢晓芳熊亮
Owner CHENGDU UNIV OF TRADITIONAL CHINESE MEDICINE
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