Mesoporous carbon nanoparticles and application thereof

Abstract

The invention discloses mesoporous carbon nanoparticles modified by macromolecules and the application thereof in preparation of drug carriers. The macromolecules refer to PVP (Polyvinyl Pyrrolidone)or DSPE-mPEG2000. According to the invention, the well aligned mesoporous carbon nanoparticles are synthetized through a low-concentration hydrothermal method, the macromolecule with biocompatibilityis used for modification through strong absorption of the mesoporous carbon nanoparticles, so that the hydrophilia and the dispersibility of the mesoporous carbon nanoparticles are improved. Through aseries of representations and cellular uptake experiments, the following conclusions are drawn: the synthetic well aligned mesoporous carbon nanoparticles are about 90 nm in diameter, uniform in nanoparticles and well aligned in mesoporous passages. PVP (Polyvinyl Pyrrolidone) and DSPE-mPEG2000 are successfully used for modification onto the surfaces of mesoporous carbon nanoparticles, so that the hydrophilia and the dispersibility of the mesoporous carbon nanoparticles are improved, the mesoporous carbon nanoparticles can be taken in by normal cells and cancer cells within 2 hours, to assemble on cytoplasm. The mesoporous carbon nanoparticles provided by the invention can be used as excellent drug carriers, and can be targeted at tumor tissues through an EPR (enhanced permeability and retention) effect.

Description

technical field [0001] The invention relates to the technical field of biomedicine, in particular to a mesoporous carbon nanoparticle and its application. Background technique [0002] Mesoporous carbon is a new type of carbon nanomaterial with a pore size between 2nm and 50nm. Mesoporous carbon not only has the properties of general mesoporous materials such as large specific surface area, pore volume and adjustable pore size, but also has the properties of general carbon such as thermal stability and inertness to chemical reactions. It has broad application prospects in the fields of electrochemistry, biology and so on. For highly dispersed drug molecules, mesoporous carbon has a large specific surface area and pore volume, which can provide high drug-loading capacity; it has an adjustable and ordered mesoporous structure and pores, which can control the release of drug molecules inside, so as Drug delivery systems have great application prospects. [0003] The Chinese ...

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In the prior art, there are no reports about the mesoporous carbon nanoparticles of the present invention and their applications

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