Terahertz non-double anisotropic metamaterial label-free sensor and its preparation and application

Abstract

The invention relates to a terahertz non-bianisotropic metamaterial unmarked sensor, and a preparation method and a use thereof, and belongs to the biotechnical field. The unmarked sensor comprises aflexible substrate polyimide, a metal layer is arranged on the flexible substrate polyimide, the metal layer comprises a lower titanium metal layer having a thickness of 20 nm and an upper gold metallayer having a thickness of 200 nm, the titanium metal layer is arranged on the flexible substrate polyimide, and the metal layer is a metal resonance ring with two openings. The asymmetric metal resonance ring with two openings is designed to realize electromagnetic induction of a transparent formant, the surface of a metamaterial is inoculated with cells through cell culture, the resonance frequency shift of a device is detected in a back transmission manner, and the theoretic sensitivity reaches up to 455 GHz / RIU, so the concentration of cancer cells can be rapidly preliminarily detected inan unmarked manner, and the apoptosis trend of oral cancer cells HSC3 under different anticancer drug action times is obtained.

Description

technical field [0001] The invention relates to a terahertz non-double-anisotropic superstructure material label-free sensor, its preparation and use, and belongs to the field of biotechnology. Background technique [0002] The application of terahertz technology in public security, communication, and biomedicine has attracted much attention. Terahertz metamaterials can achieve controllable electromagnetic response by designing the corresponding unit geometry, that is, people can flexibly control their electromagnetic properties only by designing the resonant structure. It has shown great application prospects in functional devices such as structural materials label-free sensors, especially in the highly sensitive sensing and identification of biological samples. Traditional flow cytometry can detect the cell concentration by labeling, but the test time is long and the cost is high. Contents of the invention [0003] The invention provides a terahertz non-bi-anisotropic ...

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Problems solved by technology

[0003] The invention provides a terahertz non-bi-anisotropic superstructure material label-free sensor, a preparation method and a method for testing cancer cell concentration and apoptosis trend, which solve the problems of long test time and high cost in traditional flow cytometry label detection technology. Insufficient, the realization of the detection process is short and the detection cost is low

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