CircRNA marker used for breast cancer diagnosis and application of marker

Abstract

The invention relates to a circRNA marker used for breast cancer diagnosis and an application of the circRNA marker. Compared with healthy control groups, it is found that expression of 3 kinds of circRNA (hsa_circ_0000745, hsa_circ_0001531 and hsa_circ_0001640) in whole blood of breast cancer is up-regulated. ROC curve analysis displays that the marker can better distinguish breast cancer patients and healthy people, and the 3 kinds of circRNA have the AUCs (area under curve) of 0.7998, 0.8253 and 0.7161 respectively, the sensitivity of 48.53%, 92.65% and 73.53% respectively and the specificity of 100%, 69.23% and 69.23% respectively.

Description

technical field

[0001] The disclosure belongs to the field of biomedicine, and in particular relates to a circRNA marker for breast cancer diagnosis and its application. Background technique

[0002] The statements herein merely provide background information related to the present disclosure and may not necessarily constitute prior art.

[0003] Breast cancer is a malignant tumor that occurs in the glandular epithelial tissue of the mammary gland, which seriously threatens women's health. The occurrence and development of breast cancer are related to the abnormal expression of many tumor markers. At present, there are many breast cancer tumor markers: progesterone receptor (PR), vascular endothelial growth factor (VEGF), estrogen receptor (ER ), CD44, p53, etc. But its real clinical application is very limited. Therefore, it is very important and urgent to further develop new non-invasive biomarkers for detecting breast cancer with higher sensitivity and specificity. ...

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