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Self-repairing supermolecule hydrogel as well as preparation method and use thereof

A supramolecular hydrogel, hydrogel technology, applied in the field of self-healing supramolecular hydrogel and its preparation and use, can solve the problems of high K+ concentration, limited application, poor stability, etc., achieve good application prospects, overcome the Easy to crystallize, unstable, good self-healing ability and biocompatibility

Active Publication Date: 2019-01-11
SICHUAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the supramolecular gel formed by guanosine has two main disadvantages: it needs a high K+ concentration and is easy to crystallize in a short time, resulting in poor stability (within 24h), which greatly limits its Applications

Method used

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  • Self-repairing supermolecule hydrogel as well as preparation method and use thereof
  • Self-repairing supermolecule hydrogel as well as preparation method and use thereof
  • Self-repairing supermolecule hydrogel as well as preparation method and use thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0022] Embodiment 1, the preparation of hydrogel of the present invention

[0023] Dissolve 2.8 mg of L-type guanosine in 200 μl of 0.2 M KCl solution, heat to 100°C, and after the L-type guanosine is completely dissolved, cool at room temperature to form 1.4wt% L-type guanine nucleus Glycoside supramolecular hydrogel (LG for short).

Embodiment 2

[0024] Embodiment 2, the preparation of hydrogel of the present invention

[0025] Dissolve 5.6mg of L-guanosine in 200μl of 0.2M KCl solution, heat to 100°C, after L-guanosine is completely dissolved, cool at room temperature to form L-guanosine supramolecular water Gel (referred to as LG).

Embodiment 3

[0026] Embodiment 3, the preparation of hydrogel of the present invention

[0027] Dissolve 8.4mg of L-guanosine in 200μl of 0.2M KCl solution, heat to 100°C, after L-guanosine is completely dissolved, cool at room temperature to form L-guanosine supramolecular water Gel (referred to as LG).

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Abstract

The invention provides self-repairing supermolecule hydrogel as well as a preparation method and use thereof. Particularly, the supermolecule hydrogel is prepared by the steps of dissolving L-type guanosine into a potassium chloride water solution, heating until boiling, and cooling at the room temperature after L-type guanosine is completely dissolved, so as to obtain the supermolecule hydrogel.Experimental results prove that the supermolecule hydrogel formed through the self-assembling of L-form guanosine has the advantages that the defects of D-type guanosine hydrogel are overcome, and thesupermolecule hydrogel presents very good self-repairing capacity and biocompatibility and has very good application prospects in the field of biological medicine.

Description

technical field [0001] The invention relates to a self-repairing supramolecular hydrogel, a preparation method and application thereof. Background technique [0002] Hydrogel is a polymer material with cross-linked structure, which is hydrophilic but water-insoluble and can absorb a large amount of water (usually the water content is greater than 50% of the total mass) with water as the dispersion medium. Because of the physical crosslinking and chemical crosslinking between polymer chains, it will not dissolve in water, but can only swell and maintain a certain shape. At the same time, it also has good water permeability and biocompatibility. It can be used as a human implant Can reduce adverse reactions. Therefore, hydrogels have been widely used as excellent biomedical materials. [0003] Hydrogels are divided into two types: chemical gels and physical gels; chemical gels (also known as molecular gels): gel molecules are connected by covalent bonds and have no thermal r...

Claims

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Application Information

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IPC IPC(8): C08J3/075C08L87/00C08G83/00
CPCC08G83/008C08J3/075C08J2387/00
Inventor 赵行杜玉琦曾昕陈谦明
Owner SICHUAN UNIV
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