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A kind of self-healing supramolecular hydrogel and preparation method and use thereof

A supramolecular hydrogel, hydrogel technology, applied in the field of self-healing supramolecular hydrogel and its preparation and use, can solve the problems of high K+ concentration, limited application, poor stability, etc., achieve good application prospects, overcome the Easy to crystallize, unstable, good self-healing ability and biocompatibility

Active Publication Date: 2020-12-18
SICHUAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the supramolecular gel formed by guanosine has two main disadvantages: it needs a high K+ concentration and is easy to crystallize in a short time, resulting in poor stability (within 24h), which greatly limits its Applications

Method used

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  • A kind of self-healing supramolecular hydrogel and preparation method and use thereof
  • A kind of self-healing supramolecular hydrogel and preparation method and use thereof
  • A kind of self-healing supramolecular hydrogel and preparation method and use thereof

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] Embodiment 1, the preparation of hydrogel of the present invention

[0023] Dissolve 2.8 mg of L-type guanosine in 200 μl of 0.2 M KCl solution, heat to 100°C, and after the L-type guanosine is completely dissolved, cool at room temperature to form 1.4wt% L-type guanine nucleus Glycoside supramolecular hydrogel (LG for short).

Embodiment 2

[0024] Embodiment 2, the preparation of hydrogel of the present invention

[0025] Dissolve 5.6mg of L-guanosine in 200μl of 0.2M KCl solution, heat to 100°C, after L-guanosine is completely dissolved, cool at room temperature to form L-guanosine supramolecular water Gel (referred to as LG).

Embodiment 3

[0026] Embodiment 3, the preparation of hydrogel of the present invention

[0027] Dissolve 8.4mg of L-guanosine in 200μl of 0.2M KCl solution, heat to 100°C, after L-guanosine is completely dissolved, cool at room temperature to form L-guanosine supramolecular water Gel (referred to as LG).

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Abstract

The present invention provides a self-repairing supramolecular hydrogel and its preparation method and application. Specifically, the supramolecular hydrogel is prepared by the following method: take L-type guanosine and dissolve it in chlorinated Potassium solution, heated to boiling, after the L-guanosine is completely dissolved, cooled at room temperature to form a supramolecular hydrogel. Experimental results prove that the supramolecular hydrogel formed by self-assembly of L-guanosine provided by the present invention not only overcomes the defects of D-guanosine hydrogel, but also exhibits good self-repair ability and Biocompatibility, so it has a good application prospect in the field of biomedicine.

Description

technical field [0001] The invention relates to a self-repairing supramolecular hydrogel, a preparation method and application thereof. Background technique [0002] Hydrogel is a polymer material with cross-linked structure, which is hydrophilic but water-insoluble and can absorb a large amount of water (usually the water content is greater than 50% of the total mass) with water as the dispersion medium. Because of the physical crosslinking and chemical crosslinking between polymer chains, it will not dissolve in water, but can only swell and maintain a certain shape. At the same time, it also has good water permeability and biocompatibility. It can be used as a human implant Can reduce adverse reactions. Therefore, hydrogels have been widely used as excellent biomedical materials. [0003] Hydrogels are divided into two types: chemical gels and physical gels; chemical gels (also known as molecular gels): gel molecules are connected by covalent bonds and have no thermal r...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08J3/075C08L87/00C08G83/00
CPCC08G83/008C08J3/075C08J2387/00
Inventor 赵行杜玉琦曾昕陈谦明
Owner SICHUAN UNIV
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