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Marker for predicting insulin resistance level of pregnant woman with gestational diabetes mellitus by using B lymphocyte ratio, and application thereof

A technology of B lymphocytes and insulin resistance, which is applied in the medical field and can solve problems such as few researches on its effects

Active Publication Date: 2019-01-15
SHANGHAI FIRST PEOPLES HOSPITAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0005] Unfortunately, most of the known research data are obtained from animal models, and there are few studies on the role of immune cells, especially B lymphocytes, in insulin resistance of human tissues and organs

Method used

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  • Marker for predicting insulin resistance level of pregnant woman with gestational diabetes mellitus by using B lymphocyte ratio, and application thereof
  • Marker for predicting insulin resistance level of pregnant woman with gestational diabetes mellitus by using B lymphocyte ratio, and application thereof
  • Marker for predicting insulin resistance level of pregnant woman with gestational diabetes mellitus by using B lymphocyte ratio, and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0034] 1. Materials and methods

[0035] 1. Research object

[0036] A total of 124 pregnant women with gestational diabetes and 168 pregnant women without gestational diabetes who were hospitalized in the Department of Obstetrics and Gynecology of Shanghai First People's Hospital from January to March 2016 were randomly selected. This experiment was approved by the Ethics Committee of Shanghai Jiao Tong University School of Medicine.

[0037] 2. Blood test indicators

[0038] All blood tests were completed at the Laboratory Department of Shanghai First People's Hospital. After the patient fasted for 8 hours, peripheral blood samples were taken, and biochemical indicators including red blood cells, platelets, white blood cells, triglycerides, cholesterol, glycosylated hemoglobin, glycosylated serum protein, and lactate dehydrogenase were detected.

[0039] 3. Flow cytometry detection

[0040] 3.1 Flow cytometry sorting

[0041] Take 50ul of blood samples and place them in t...

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Abstract

The invention relates to the field of medical technology, and specifically discloses a marker for predicting an insulin resistance level of a pregnant woman with gestational diabetes mellitus by usinga B lymphocyte ratio, and an application thereof. Research result shows that the B lymphocyte ratio in the peripheral blood of the pregnant woman with the gestational diabetes mellitus has statistical difference with the B lymphocyte ratio in the peripheral blood of the pregnant woman without the gestational diabetes mellitus. Analysis result show that the B lymphocyte ratio is in positive correlation with the insulin resistance level. ROC curve analysis shows that the B lymphocyte ratio14.05% is an accurate and ideal cut-off value, and the biochemical indicators of the pregnant woman with the gestational diabetes mellitus can be well distinguished from the biochemical indicators of the pregnant woman without the gestational diabetes mellitus. The invention firstly proposes to use the B lymphocyte ratio as a predictive index of the insulin resistance level of the pregnant woman with the gestational diabetes mellitus, a new method for effectively predicting the insulin resistance levelof the pregnant woman with the gestational diabetes mellitus is provided by the disclosure of the new marker of the B lymphocyte ratio, in order to better guide the treatment of the insulin resistance of the pregnant woman with the gestational diabetes mellitus.

Description

technical field [0001] The invention relates to the field of medical technology, specifically, the B lymphocyte ratio as a marker for predicting the insulin resistance level of pregnant women with gestational diabetes mellitus and its application. Background technique [0002] Gestational diabetes is a pregnancy complication characterized by hyperglycemia. Although the etiology is unknown, current studies suggest that the occurrence of GDM is related to insulin resistance and functional damage of islet β cells. The incidence of GDM ranges from 0.6% to 15% due to differences in regions, races and diagnostic criteria. Risk factors for its onset include high pre-pregnancy body mass index, sedentary lifestyle, older age at conception, or genetics. GDM seriously threatens the health of mother and child. Pregnant women with GDM have a significantly higher risk of postpartum type 2 diabetes. Moreover, the risk of cardiovascular disease in pregnant women with GDM is much higher ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N33/50G01N33/569
CPCG01N33/5052G01N33/56966G01N2800/042G01N2800/368
Inventor 庄研贺银燕张进顾红琴张佳荣陆慧芳翁剑蓉徐先明
Owner SHANGHAI FIRST PEOPLES HOSPITAL
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