Novel application of stachydrine hydrochloride in prevention and treatment ischemic cerebrovascular diseases

A technique for cerebrovascular disease and stachydine hydrochloride, applied in the field of medicine, can solve the problems such as no literature report of stachydrine hydrochloride, and achieve the effect of obvious cerebral ischemia protection effect and good application effect.

Inactive Publication Date: 2019-02-19
上海市浦东新区浦南医院 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] At present, there is no literature reporting stach

Method used

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  • Novel application of stachydrine hydrochloride in prevention and treatment ischemic cerebrovascular diseases
  • Novel application of stachydrine hydrochloride in prevention and treatment ischemic cerebrovascular diseases
  • Novel application of stachydrine hydrochloride in prevention and treatment ischemic cerebrovascular diseases

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] Embodiment 1. The animal experiment that stachydrine hydrochloride is used for the treatment of ischemic cerebrovascular disease

[0025] The pharmacological experiment of making a model of regional cerebral ischemia-reperfusion injury by rat suture method is a commonly used animal experiment to verify that drugs have the effect of preventing and treating ischemic cerebrovascular disease. Therefore, it is used to verify the effect of stachydrine hydrochloride on cerebral ischemia in experimental animals. Protective effects.

[0026] 1.1 Animals

[0027] Healthy male SD rats, weighing 240-280 g. Purchased from Shanghai Slack Experimental Animal Co., Ltd., quality certificate number (animal certificate number: SCXK (Shanghai) 2013-0016). Raised in a clean animal room.

[0028] 1.2 Drugs

[0029] Group the experimental rats into groups:

[0030] Sham operation group: give the same amount of normal saline as the drug experiment group, without cerebral ischemia operatio...

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PUM

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Abstract

The invention relates to novel application of stachydrine hydrochloride, in particular to application of stachydrine hydrochloride in the preparation of drugs, foods or health products to prevent andtreat ischemic cerebrovascular diseases. Pharmacological tests via a rat focal cerebral ischemia model verify that the stachydrine hydrochloride is capable of evidently lowering area percentage of brain injury due to focal cerebral ischemia caused by rat suture occlusion, evidently improving post-ischemic neural behaviors of a rat, increasing the SOD content in serum and lowering MDA content. Thestachydrine hydrochloride has great brain protection; with low molecular weight, the stachydrine hydrochloride has significant brain permeability. The stachydrine hydrochloride is well applicable to the prevention and treatment of ischemic cerebrovascular diseases.

Description

technical field [0001] The invention relates to the field of medicine, in particular to the new application of stachydrine hydrochloride in the prevention and treatment of ischemic cerebrovascular diseases. Background technique [0002] Stachydrine hydrochloride (stachydrine) is the main alkaloid component in Lamiaceae plant Motherwort, chemical formula C 7 h 13 NO 2 ·The molecular weight of HCl is 179.5, and the CAS number is 471-87-4. The molecular structural formula is shown in formula (I) [0003] [0004] Studies have shown that stachydrine hydrochloride has the functions of promoting blood circulation, regulating menstruation, diuresis and swelling, and shrinking the uterus. For myocardial ischemia caused by adrenaline, it can improve coronary artery and myocardial nutritional blood flow, reduce myocardial cell necrosis rate, reduce blood viscosity, reduce vascular resistance, improve microcirculation, slow heart rate, reduce cardiac output and anti-platelet agg...

Claims

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Application Information

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IPC IPC(8): A61K31/40A61P9/10A23L33/105
CPCA23L33/105A23V2002/00A61K31/40A61P9/10A23V2200/326A23V2250/21
Inventor 李铁军刘卫东李莉冯晶晶丁华敏孙莉莉袁珺李桂香
Owner 上海市浦东新区浦南医院
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