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Device and method for rapid endothelialization of vascular stent

A vascular stent and endothelialization technology, applied in the field of rapid endothelialization equipment, can solve the problems of delayed repair of damaged blood vessels, vascular stenosis, etc., and achieve the effect of inhibiting restenosis in blood vessels and improving the speed of endothelialization

Active Publication Date: 2021-07-02
BEIJING ANZHEN HOSPITAL AFFILIATED TO CAPITAL MEDICAL UNIV +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the implantation of bare stents will cause the proliferation of smooth muscle cells, which will lead to the occurrence of postoperative vascular restenosis.
Compared with bare metal stents, drug-eluting stents can significantly reduce the risk of vascular restenosis and neointimal hyperplasia. Repair of damaged blood vessels was also delayed, eventually leading to late thrombosis and several other complications

Method used

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  • Device and method for rapid endothelialization of vascular stent
  • Device and method for rapid endothelialization of vascular stent
  • Device and method for rapid endothelialization of vascular stent

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] Such as figure 1 As shown, the rapid endothelialization device of the vascular stent of the present embodiment includes: a culture dish 1, a fixed frame 3, a fixed beam 2, a metal rod 4, a metal cylinder 6 and a pulse electric field generating device; wherein, in the tubular vascular stent 5 Endothelial cell suspension is drip-coated on the surface of the vascular stent; a metal rod 4 is set inside the vascular stent; a metal cylinder 6 is set outside the vascular stent; the central axes of the metal rod, the vascular stent and the metal cylinder are coaxial, and the three pass through the fixing frame 3 Fixed; the inner diameter of the vascular stent is larger than the radius of the metal rod; the outer diameter of the vascular stent is smaller than the inner diameter of the metal cylinder, so that there are gaps between the vascular stent and the metal rod and between the vascular stent and the metal cylinder, such as figure 2 As shown; the culture dish 1 is filled w...

Embodiment 2

[0047] Endothelial cell suspension, culture medium and rapid endothelialization equipment are the same as in Example 1.

[0048] In this embodiment, the endothelial cells dripped on the surface of the stent are stimulated with a pulsed electric field, a pulsed electric field with a pulse width of 10 ns is applied, the oscilloscope displays the voltage between the metal rod and the metal cylinder, and the field between the two electrodes is adjusted. The intensity is 5kV / cm, the frequency is 1HZ, and the number of pulse excitations is 10. Place stimulated scaffolds carrying endothelial cells in CO 2 After 24 days in the incubator, the endothelialization of the scaffold surface was observed.

[0049] Corresponding physical and chemical properties and biological characteristics of the blood vessel stent after the rapid endothelialization method of the present invention are tested, and the results show that it meets the design requirements.

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Abstract

The invention discloses a rapid endothelialization device for a blood vessel stent and a method thereof. In the present invention, the endothelial cell suspension is dripped on the surface of the vascular stent, and the inner and outer sides of the vascular stent are respectively provided with metal rods and metal cylinders, and immersed in the culture medium, and a pulse electric field is applied to the vascular stent through the metal rods and metal cylinders, so that The vascular stent is in a uniform electric field; control the pulse width, electric field intensity, pulse frequency and the number of pulse excitations of the pulsed electric field, and regulate the proliferation process of endothelial cells through physical electrical stimulation to increase the endothelialization speed of endothelial cells on the surface of the vascular stent. Ultimately achieve the purpose of inhibiting intravascular restenosis.

Description

technical field [0001] The invention relates to the technical fields of biomedical tissue engineering and regenerative medicine, in particular to a device for rapid endothelialization of vascular stents and a method thereof. Background technique [0002] With the improvement of people's living standards, people's lifestyles have also changed a lot, and the death caused by cardiovascular disease has become the leading cause of death for contemporary people. At present, endovascular interventional therapy has become one of the important methods for cardiovascular diseases, and the implantation of bare metal stents can effectively improve the problems caused by vascular stenosis. However, the implantation of bare stents will cause the proliferation of smooth muscle cells, which will lead to the occurrence of postoperative vascular restenosis. Compared with bare metal stents, drug-eluting stents can significantly reduce the risk of vascular restenosis and neointimal hyperplasia...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C12M1/42C12M3/00C12N5/071C12N13/00
CPCC12M35/02C12N5/069C12N13/00
Inventor 张宇晨董飞宏国晋菘张珏方竞
Owner BEIJING ANZHEN HOSPITAL AFFILIATED TO CAPITAL MEDICAL UNIV
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