Application of ledene in cervical cancer treatment aspect

A technology of cervical cancer and teaene, applied in the field of medicine, can solve problems such as evolution and death

Inactive Publication Date: 2019-03-08
淮安培元基因科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although complete remission can be achieved after initial surgery and chemotherapy, most patients with advanced disease will still relapse within 2 to 3 years, and eventually become resistant to chemotherapy and die

Method used

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  • Application of ledene in cervical cancer treatment aspect
  • Application of ledene in cervical cancer treatment aspect

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Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0015] The substantive content of the present invention will be described in detail below in conjunction with the embodiments, but the protection scope of the present invention is not limited thereto.

[0016] 1. Experimental materials

[0017] The structural formula of the test compound is as figure 1 As shown, including trumpetene, trumpet alcohol, cinnamonolide, isoartemisinic acid, 7-armentene-6-one and 4-arrene, the standard products are purchased or self-made, and the purity is ≥98%.

[0018] Human ovarian cancer SKOV3 cells and human cervical cancer Hela cells were purchased from the Shanghai Cell Bank of the Chinese Academy of Sciences.

[0019] DMEM / F12 medium, high-glucose DMEM medium, and fetal bovine serum were purchased from GIBCO.

[0020] Tetramethylazolazolium blue (MTT) and DMSO were purchased from SIGMA.

[0021] Double antibody solution and trypsin were purchased from Hyclone Company, USA.

[0022] 2. Experimental method

[0023] 1. Cell culture

[002...

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Abstract

The invention discloses an application of ledene in a cervical cancer treatment aspect. It is discovered that gweicurculactone, isorupestonic acid, 7-aromadendrene-6-ketone and 4-aromadendrene have the excellent anti-proliferative effect to a human ovarian cancer SKOV3 cell and a human cervical cancer Hela cell; and although the ledene is a dehydration product of palustrol from a chemical structure, and the chemical structure is more similar, a difference of proliferation inhibition activity to the human ovarian cancer SKOV3 cell and the human cervical cancer Hela cell is larger, wherein the ledene is apparent for the anti-proliferative effect to the human cervical cancer Hela cell, and not apparent for the anti-proliferative effect to the human ovarian cancer SKOV3 cell, but the palustrolis apparent for the anti-proliferative effect to the human ovarian cancer SKOV3 cell, and not apparent for the anti-proliferative effect to the human cervical cancer Hela cell. All of the ledene, thepalustrol, the gweicurculactone, the isorupestonic acid, the 7-aromadendrene-6-ketone and the 4-aromadendrene can be used for treating gynecological oncology.

Description

technical field [0001] The invention belongs to the field of medicine, relates to gynecology, and specifically relates to the application of trumpetylene in the treatment of cervical cancer. Background technique [0002] Gynecological tumor is a common and frequently-occurring disease that seriously threatens women's health, and can be divided into benign and malignant. Common gynecological benign tumors include ovarian benign tumors, ovarian tumor-like lesions (simple ovarian cysts and ovarian chocolate cysts, etc.), pelvic inflammatory masses, adenomyosis, and uterine fibroids. The specific methods include surgery, drugs, intervention, etc., among which surgery is the main treatment method, but its damage to ovarian function has been in recent years. has been gradually paid attention to. Traditional Chinese medicine treatment of gynecological benign tumors can control and reduce the tumor size for patients who do not meet the surgical indications, so as to avoid surgical...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/045A61K31/015A61K31/122A61K31/19A61K31/365A61P35/00
CPCA61K31/045A61K31/015A61K31/122A61K31/19A61K31/365A61P35/00
Inventor 张长林杨佳
Owner 淮安培元基因科技有限公司
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